Kai Chieko

カイチエコ | Kai Chieko

Affiliation and department：
Research theme for competitive and other funds (27)：

2023 - 2027 麻疹ウイルスベクターを用いたニパウイルス感染症ワクチンの開発
2020 - 2023 遺伝子組換え麻疹ウイルスを用いた抗がんウイルス療法の臨床研究
2019 - 2023 Development of a Nipah measles vector vaccine (MV-NIV) to be used in outbreaks situation in children and adults exposed population
2017 - 2020 遺伝子組換え麻疹ウイルスを用いた癌治療法の開発
2016 - 2020 Comprehensive analysis of acetylation network post morbillivirus infection using novel analysis method

2016 - 2019 Molecular basis underlying anti-tumor activity of an oncolytic measles virus

2016 - 2019 Establishment of humanized mice as a small animal model for measles virus infection

2014 - 2017 Development of measles virus vector-based vaccine against highly pathogenic avian influenza virus

2015 - 2016 癌治療用組換え麻疹ウイルスの開発

2010 - 2016 Analysis of host cellular transcriptional network induced by mononegavirus infection.

2010 - 2010 モービリウイルスの感染宿主細胞応答制御機構の解明

2009 - 2010 ニパウイルスの病原性発現機構の解析

2007 - 2009 Analysis of factors implicated in pathogenicity of mononegaviruses and development of a vaccine candidate.

2007 - 2008 Reverse geneticsを用いたニパウイルスの病原性発現機構の解析

2004 - 2005 Establishment and analysis of measles virus-susceptible transgenic mice.

2003 - 2004 The development of animal model using squirrel monkey (Saimiri sciureus boliviensis) for human malaria infection

2002 - 2003 Development of the new vaccine and a delivery vector by the recombination Morbilli virus.

2000 - 2003 Analysis of the species specific pathogenicity of morbillivirus by reverse genetics.

2002 - 2002 新組み換え技術を用いたがん治療用麻疹ウイルスベクターの開発

2002 - 2002 体細胞クローン動物の誕生によって変貌した研究フロンティアの推進

2001 - 2001 モノネガウイルスのM蛋白欠損による新型ウイルスワクチン/ベクターの開発

2001 - 2001 C型肝炎ウイルスのツパイ感染実験モデル系の開発

2000 - 2001 遺伝的発症モデル動物を用いた海綿状脳症形成機構の解析

1999 - 2001 Development of Immune Induction System by Using The Novel Virus Vectors of Cytokines

1997 - 2001 動物ウイルスによる宿主細胞の制圧機構の解明

1999 - 1999 ウイルスの感染・増殖における宿主細胞の細胞骨格系の役割

1984 - 1984 ニワトリ補体蛋白の基礎性状の解析

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Papers (212)：

Tomoyuki Nanamiya, Kiyoko Takane, Kiyoshi Yamaguchi, Yuya Okawara, Mariko Arakawa, Akari Saku, Tsuneo Ikenoue, Tomoko Fujiyuki, Misako Yoneda, Chieko Kai, et al. Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. Oncology reports. 2024. 51. 1
Kei Tamura, Tomoko Fujiyuki, Kanako Moritoh, Hayato Akimoto, Keigo Iizuka, Hiroki Sato, Kazushi Asano, Misako Yoneda, Chieko Kai. Anti-tumor activity of a recombinant measles virus against canine lung cancer cells. Scientific reports. 2023. 13. 1. 18168-18168
Kanako Moritoh, Koichiro Shoji, Yosuke Amagai, Tomoko Fujiyuki, Hiroki Sato, Misako Yoneda, Chieko Kai. Immune response elicited in the tumor microenvironment upon rMV-SLAMblind cancer virotherapy. Cancer science. 2023
Kei Tamura, Kumiko Ishigaki, Orie Yoshida, Terai Kazuyuki, Naoki Sakurai, Tatsuya Heishima, Tomoko Fujiyuki, Chieko Kai, Kazushi Asano. Gene expression of Nectin-4 and its clinical significance in dogs with primary lung adenocarcinoma. Veterinary medicine and science. 2022. 8. 5. 1922-1929
Sachi Sri Kantha, Juri Suzuki, Takeshi Kuraishi, Shosaku Hattori, Yasuo Kiso, Chieko Kai. Behavioral sleep of geriatric squirrel monkeys (Saimiri boliviensis) in amami oshima, japan. International Medical Journal. 2021. 28. 5. 532-534

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MISC (26)：

七宮知之, 高根希世子, 山口貴世志, 池上恒雄, 藤幸知子, 米田美佐子, 甲斐知惠子, 古川洋一. FOS transcriptionally regulates PVRL4, a receptor for measles virus. 日本癌学会学術総会抄録集(Web). 2022. 81st
甲斐知惠子, 米田美佐子. One Health, One World-A global approach on the future path of infectious disease research. 実験医学. 2021. 39. 2
Chieko Kai, Tomoko Fujiyuki, Hiroki Sato, Yataro Daigo, Misako Yoneda. Applicability of a recombinant SLAM-blind measles virus to breast cancer treatment. CANCER SCIENCE. 2018. 109. 274-274
Tomoko Fujiyuki, Koichiro Shoji, Keigo Iizuka, Yu Horikirizono, Hiroki Sato, Kazushi Asano, Misako Yoneda, Chieko Kai. Potential applicable range of oncolytic virotherapy with a recombinant measles virus in dogs. CANCER SCIENCE. 2018. 109. 1037-1037
Saku Akari, Yamaguchi Kiyoshi, Ikenoue Tsuneo, Fujiyuki Tomoko, Yoneda Misako, Hata Hiroko, Oyama Masaaki, Kai Chieko, Furukawa Yoichi. Elucidation of transcriptional regulation mechanism of PVRL4, a receptor for oncolytic measles virus. CANCER SCIENCE. 2018. 109. 979

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Lectures and oral presentations (12)：

An oncolytic recombinant measles virus, rMV-SLAMblind, is a promising candidate for cancer therapy.
(2023)
乳癌に対する腫瘍溶解性麻疹ウイルス療法の開発
(第31回日本乳癌学会学術総会 2023)
ウイルスベクターの利用による医療法開発
(第23回医薬品等ウイルス安全性シンポジウム (日本医薬品等ウイルス安全性研究会) 2023)
One Health, One World-Toward the formation of the first hub of One Health, One world
(The 1st International Symposium on One Health, One World)
ウイルスは役に立つー新しいがんの治療法ー
(取手市市民大学特別講座 2022)

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Education (3)：

Professional career (1)：

Work history (13)：

2024/10 - 現在 Teikyo University Advanced Comprehensive Research Organization
2019/09 - 2024/03 The University of Tokyo Institute of Industrial Science
2005/04 - 2019/03 The University of Tokyo
2001/04 - 2019/03 The University of Tokyo
2000/04 - 2019/03 The University of Tokyo The Institute of Medical Science, Laboratory Animal Research Center

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Committee career (39)：

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