Komorizono Ryo

コモリゾノリョウ | Komorizono Ryo

Affiliation and department：
Job title： Program-Specific Assistant Professor

Research field (3)： Molecular biology , Pharmaceuticals - chemistry and drug development , Virology

Research keywords (5)： Virology , Viral evolution , Viral vector , ワクチンモダリティ , Gene therapy

Research theme for competitive and other funds (8)：

2024 - 2026 概日リズムに基づいたウイルス感染制御とそのメカニズムの解明
2023 - 2024 ウイルス進化は概日リズムによりリズムを刻むか
2023 - 2024 The 1st step in the development of vaccine platform using a self-amplifying bornavirus vector
2022 - 2024 Nonsense mediated mRNA decayによるRNAウイルスゲノムの品質管理と進化制御
2022 - 2023 Gene cell therapy for lysosomal storage disorders using designer mesenchymal stem cells

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Papers (14)：

Ryo Komorizono, Shima Yoshizumi, Keizo Tomonaga. Development of an RNA virus-based episomal vector with artificial aptazyme for gene silencing. Applied Microbiology and Biotechnology. 2024. 108. 1
Madoka Sakai, Yoshie Masuda, Yusuke Tarumoto, Naoyuki Aihara, Yugo Tsunoda, Michiko Iwata, Yumiko Kamiya, Ryo Komorizono, Takeshi Noda, Kosuke Yusa, et al. Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection. iScience. 2024. 27. 8. 110475-110475
Chinatsu FUJIWARA, Naoyuki AIHARA, Motokazu YOSHINO, Takanori SHIGA, Kan FUJINO, Ryo KOMORIZONO, Akiko MAKINO, Keizo TOMONAGA, Reiko SOGA, Junichi KAMIIE. Distribution of lesions in psittacine birds naturally infected with parrot bornavirus in Japan. Journal of Veterinary Medical Science. 2024
Junya Sunagawa, Hyeongki Park, Kwang Su Kim, Ryo Komorizono, Sooyoun Choi, Lucia Ramirez Torres, Joohyeon Woo, Yong Dam Jeong, William S. Hart, Robin N. Thompson, et al. Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution. Nature Communications. 2023. 14. 1
Ryo Komorizono, Kan Fujino, Susanne Kessler, Solveig Runge, Takehiro Kanda, Masayuki Horie, Akiko Makino, Dennis Rubbenstroth, Keizo Tomonaga. Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation. Journal of Virology. 2023. 97. 8

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MISC (2)：

A. Makino, R. Komorizono, M. Sakai, K. Tomonaga. Improvement of the production of Borna disease virus vector. HUMAN GENE THERAPY. 2016. 27. 11. A184-A185
A. Makino, R. Komorizono, S. J. Holditch, B. Lu, T. Honda, Y. Ikeda, K. Tomonaga. A novel RNA virus-based episomal vector system for long-term stem cell modification. HUMAN GENE THERAPY. 2015. 26. 10. A26-A27

Patents (3)：

Lectures and oral presentations (26)：

一過性発現型ボルナウイルスベクターの開発とその応用
(第71回日本ウイルス学会学術集会 2024)
Self-amplifying RNA viral vector for gene therapy and vaccine platform development
(BIO International Convention 2024)
多発性硬化症治療を目指したmiRNA分泌型遺伝子細胞治療薬の開発
(2023)
Application of self-amplifying viral vector "REVec"
(BioJapan2023)
Excel-REGENS: The ex vivo gene cell therapy using REVec-based genetically engineered stem cells.
(The 70th annual meeting of the Japanese Society for Virology 2023)

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Education (3)：

2017 - 2020 Kyoto University Graduate School of Biostudies
2015 - 2017 Kyoto University Graduate School of Biostudies
2011 - 2015 Kagoshima University Faculty of Agriculture Biochemical Science and Technology

Professional career (1)：

Work history (4)：

2024/09 - 現在 The University of Tokyo The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center Project Assistant professor
2022/04 - 現在 Kyoto University Institute for Life and Medical Sciences Program-Specific Assistant Professor
2020/04 - 2022/03 Kyoto University Institute for frontier life and medical sciences Researcher
2017/04 - 2020/03 Japan Society for the Promotion of Science

Awards (4)：

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