Rchr
J-GLOBAL ID：202201019708691325
Update date: Oct. 02, 2024
HIROAKI TAKESUE
タケスエ ヒロアキ | HIROAKI TAKESUE
Affiliation and department：
Job title：
Assistant Professor
Research field (1)：
Systems genomics
Research keywords (2)：
Saccaromyces cerevisiae, tandem repeat, CUP1, Cas9, copy number variation
, Saccharomyces cerevisiae, CUP1, Cas9, histone modification, copy number variation
Research theme for competitive and other funds (5)：
- 2024 - 2026 構造多型への構成的アプローチ:Cas9ニッケースとスプリントDNAによる誘導
- 2024 - 2024 二倍体細胞におけるBITRExの検討:interchromatid vs. interhomolog BIR
- 2023 - 2024 Challenge to create multigene families by simultaneous induction of tandem repeat expansion and mutation
- 2023 - 2023 Cas9ニッケースの複数遺伝子座への同時誘導による高度な遺伝子増幅系の構築
- 2022 - 2022 Cas9ニッケースを用いた新手法によって遺伝子の安定な高発現系を構築する
Papers (8)：
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Hiroaki Takesue, Satoshi Okada, Goro Doi, Yuki Sugiyama, Emiko Kusumoto, and Takashi Ito. Strategic targeting of Cas9 nickase expands tandem gene arrays. bioRxiv. 2024
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Hisako Takigawa-Imamura, Katsumi Fumoto, Hiroaki Takesue, Takashi Miura. Exploiting mechanisms for hierarchical branching structure of lung airway. PLoS ONE. 2024
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Okura, Y., Ikawa-Teranishi, Y., Mizoroki, A., Takahashi, N., Tsushima, T., et al. Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease. Nature communications. 2023
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Yuki Noguchi, Kazuhisa Ozeki, Hiroaki Takesue, Hidetaka Akita. A cell based assay for evaluating binding and uptake of an antibody using hepatic nonparenchymal cells. Scientific Reports. 2021
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Genki Nakamura, Kazuhisa Ozeki, Hiroaki Takesue, Mitsuyasu Tabo, Ken-ichi Hosoya. Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model. Biological and Pharmaceutical Bulletin. 2021. 44. 3. 389-395
ｍore...
MISC (1)：
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Takeshi Hirota, Toshihiro Tanaka, Hiroaki Takesue, Ichiro Ieiri. Epigenetic regulation of drug transporter expression in human tissues. Expert Opinion on Drug Metabolism and Toxicology. 2017
Lectures and oral presentations (15)：
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出芽酵母を用いたCas9ニッケースの戦略的配置による縦列反復構造の伸長
(酵母遺伝学フォーラム第57回研究報告会 2024)
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相同配列を利用して必死に生きようとする出芽酵母
(第10回酵母研究若手の会 2024)
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Effective sgRNA search method for Cas9 nickase-based tandem repeat expansion and its application to HEK293T cells
(2024)
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Parallel BITREx to generate a population of cells diversified in copy number ratios between target genes
(2024)
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Considering the application of BiTREx, a method for tandem repeat expansion by strategic targeting of Cas9 nickase
(2023)
ｍore...
Education (3)：
- 2015 - 2018 Kyushu University
- 2013 - 2015 Kyushu University
- 2009 - 2013 Kyushu University
Professional career (1)：
- Pharmaceutical science (Kyushu University)
Work history (4)：
- 2022/04 - 現在 Kyushu University Department of Biochemistry Assistant Professor
- 2021/04 - 2022/03 Kyushu University Department of Biochemistry Specially Appointed Assistant Professor
- 2019/01 - 2021/03 Chugai Pharmaceutical Co., Ltd.
- 2018/04 - 2018/12 Chugai Pharmaceutical Co., Ltd.
Committee career (3)：
- 2024/10 - 2025/09 Steering committee chair
- 2024/04 - 2025/03 九州大学 准教授・講師・助教候補者選考委員会
- 2023/10 - 2024/09 Steering committee member
Awards (2)：
- 2023/03 - 公益社団法人 日本農芸化学会 2023年度大会トピックス賞
- 2015/09 - The Academy of Pharmaceutical Science and Technology, Japan Global Education Seminar Presentation Award 2015
Association Membership(s) (5)：
Yeast Genetics Society of Japan
, The Japan Society for Genome Editing
, Japan Society of Bioscience, Biotechnology, and Agrichemistry
, The Molecular Biology Society of Japan
, 酵母研究若手の会
