KAWAGUCHI SATOSHI

カワグチサトシ | KAWAGUCHI SATOSHI

Affiliation and department：
Job title： Assistant professor

Research field (2)： Emergency medicine , Cardiology

Research keywords (7)： MicrioRNA , Long noncoding RNA , Beta adrenergic receptor , Emergency medicine , Ischemic heart disease , Sepsis , Heart failure

Research theme for competitive and other funds (5)：

2024 - 2027 Development of a novel therapeutic strategy for sepsis induced cardiomyopathy through the mechanism of nitric oxide regulation
2021 - 2024 The role of beta-3 receptors and sphingosine 1-phosphate in the regulation of myocardial metabolism in sepsis
2018 - 2022 Elucidation of myocardial energy metabolism via beta-3 receptor in sepsis
2020 - 2021 Clarification of the mechanism for beta-3 adrenergic receptor regulation of Inducible nitric oxide synthase in septic cardiomyopathy
2018 - 2019 The Beta;adrenergic receptor has a;possibility to improve the mortality with;sepsis-induced cardiac dysfunction by regulating cardiac metabolism

Papers (11)：

Hirofumi Sakuma, Keisuke Maruyama, Tatsuya Aonuma, Yuya Kobayashi, Taiki Hayasaka, Kohei Kano, Satoshi Kawaguchi, Kei-Ichi Nakajima, Jun-Ichi Kawabe, Naoyuki Hasebe, et al. Inducible deletion of microRNA activity in kidney mesenchymal cells exacerbates renal fibrosis. Scientific reports. 2024. 14. 1. 10963-10963
Satoshi Kawaguchi, Bruno Moukette, Marisa N Sepúlveda, Taiki Hayasaka, Tatsuya Aonuma, Angela K Haskell, Jessica Mah, Suthat Liangpunsakul, Yaoliang Tang, Simon J Conway, et al. SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation. Cell death & disease. 2023. 14. 7. 446-446
Satoshi Kawaguchi, Bruno Moukette, Taiki Hayasaka, Angela K Haskell, Jessica Mah, Marisa N Sepúlveda, Yaoliang Tang, Il-Man Kim. Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases. Journal of cardiovascular development and disease. 2023. 10. 4
Bruno Moukette, Satoshi Kawaguchi, Marisa N Sepulveda, Taiki Hayasaka, Tatsuya Aonuma, Suthat Liangpunsakul, Lei Yang, Rohan Dharmakumar, Simon J Conway, Il-Man Kim. MiR-150 blunts cardiac dysfunction in mice with cardiomyocyte loss of β1-adrenergic receptor/β-arrestin signaling and controls a unique transcriptome. Cell death discovery. 2022. 8. 1. 504-504
Tatsuya Aonuma, Bruno Moukette, Satoshi Kawaguchi, Nipuni P Barupala, Marisa N Sepúlveda, Kyle Frick, Yaoliang Tang, Maya Guglin, Subha V Raman, Chenleng Cai, et al. MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long Noncoding RNA MIAT and Directly Represses Profibrotic Hoxa4. Circulation. Heart failure. 2022. 15. 4. e008686

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MISC (1)：

Motoi Okada, Satoshi Kawaguchi, Yuta Kashiwagi, Kentaro Hayashi, Satoshi Fujita, Naoyuki Hasebe. Carvedilol Improves Prognosis in Sepsis-induced Cardiomyopathy Through the Activation of "telomere-p53-pgc Signaling". CIRCULATION. 2016. 134

Books (2)：

循環器症候群(第3版) III
日本臨牀 2019
救急・集中治療 28臨時増刊号
総合医学社 2016

Lectures and oral presentations (9)：

Pathophysiology in Sepsis induced cardiomyopathy
(The 88th Anual Scientific Meeting of the Japanese Circulation Society 2024)
Small Proline-rich Repeat Protein 1a Is A Significant Functional Target Of Microrna-150 In Mouse Hearts And Human Cardiac Fibroblasts
(American Heart Association scientific session)
MicroRNA-125a-5p protects the heart from ischemic injury by directly repressing pro-apoptotic GTP cyclohydrolase 1 feed regulator (GCHFR) in cardiomyocytes
(Annual meeting of the Indiana Physiological Society)
Cardiac metabolism was improved by regulation of nitric oxide synthase through β3-adrenergic receptor in endotoxin-induced failing heart
(American Heart Association scientific session)
Endotoxin-induced cardiac metabolic shift is controlled through the regulation of fatty acid oxidation by β3-adrenergic receptor
(American Heart Association scientific session)

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Education (2)：

2016 - 2020 Asahikawa Medical University
2004 - 2010 Asahikawa Medical University School of Medicine Medical Course

Work history (7)：

2023/03 - 現在 Asahikawa Medical University Department of emergency medicine Assistant professor
2020/09 - 2023/02 Indiana University School of Medicine Department of Anatomy, Cell Biology & Physiology Postdoctral fellow
2020/04 - 2020/09 Asahikawa Medical University Department of intensive care unit Assistant professor
2016/11 - 2020/03 Asahikawa Medical University Department of emergency Assistant professor
2015/04 - 2016/10 Asahikawa Medical University Department of cardiology Staff

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Awards (2)：

2022/11 - AHA Scientific session BCVS travel grant
2022/01 - American HeartAssociation AHA postdoctoral fellowship The roles of GCHFR and its cardiomyocyte post-transcriptional inhibitor in ischemic cardiac injury

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