Rchr
J-GLOBAL ID：202301005924704039
Update date: Feb. 28, 2023
Obita Takayuki
オビタ タカユキ | Obita Takayuki
Affiliation and department：
Job title：
Associate professor
Research theme for competitive and other funds (10)：
- 2022 - 2025 自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
- 2020 - 2023 Structural study of pro-filaggrin recognition by SASPase
- 2019 - 2022 How does PQBP1 suppress the induction of type I interferon expression by cGAS?
- 2016 - 2019 Structural Study of basal transcription factor TFIIE
- 2015 - 2018 Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
- 2014 - 2016 Structural basis of Archaeal ESCRT complex
- 2012 - 2015 Verification of the connector function of the transcription and splicing factor PQBP1
- 2012 - 2014 Structural basis of the filament formation of ESCRT-III proteins
- 2010 - 2011 A structural study towards the understanding of the roles of Archaeal ESCRT in cell division.
- 2004 - 2006 ミトコンドリア・プレ配列レセプターTom20によるプレ配列認識の構造的基盤
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Papers (35)：
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Mei Nakagawa, Takayuki Obita, Mineyuki Mizuguchi. The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin. The Biochemical journal. 2022. 479. 18. 1999-2011
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Takayuki Obita, Koji Inaka, Daisuke Kohda, Nobuo Maita. Crystal structure of the PX domain of Vps17p from Saccharomyces cerevisiae. Acta crystallographica. Section F, Structural biology communications. 2022. 78. Pt 5. 210-216
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Gabriel Krasovec, Akiko Hozumi, Tomoyuki Yoshida, Takayuki Obita, Mayuko Hamada, Akira Shiraishi, Honoo Satake, Takeo Horie, Hisashi Mori, Yasunori Sasakura. d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona. Science advances. 2022. 8. 10. eabn3264
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Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, et al. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nature communications. 2021. 12. 1. 6565-6565
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Takayuki Obita, Rieko Kojima, Mineyuki Mizuguchi. Crystallization and Biophysical Approaches for Studying the Interactions Between the Vps4-MIT Domain and ESCRT-III Proteins. Methods in molecular biology (Clifton, N.J.). 2019. 1998. 175-187
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Patents (2)：
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