Rchr
J-GLOBAL ID：202301009809209283   Update date: Dec. 03, 2024

Tatekoshi Yuki

タテコシ ユウキ | Tatekoshi Yuki
Affiliation and department：
Sapporo Medical University School of Medicine Department of Pharmacology

About Sapporo Medical University School of Medicine Department of Pharmacology


Job title： Assistant professor
Homepage URL  (1)： https://web.sapmed.ac.jp/pharmacology/index.html
Research field  (3)： Cardiology ,  Medical biochemistry ,  Pathobiochemistry
Research keywords  (6)： Heart failure ,  HFpEF ,  Cellular Metabolism ,  Endothelial cell ,  Diabetes Mellitus ,  Glycosylation
Research theme for competitive and other funds  (13)：
  • 2024 - 2029 内皮細胞が制御する耐糖能と5S-GlcNHexの新規糖尿病治療薬としての可能性
  • 2024 - 2027 Exploration of novel therapeutic approaches for HFpEF based on dynamic and functional analysis of vascular endothelial stem cells.
  • 2024 - 2026 血管内皮幹細胞のダイナミクス・機能変化解析に基づく心不全の新規治療法の探索
  • 2024 - 2025 動脈硬化リスク暴露に伴う血管内皮幹細胞の動態変化と心血管機能の関連について
  • 2024 - 2025 内皮細胞が制御する耐糖能と新規糖尿病治療薬の開発
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Papers (16)：
  • Atsushi Kuno, Ryusuke Hosoda, Yukika Saga, Naotoshi Iwahara, Yuki Tatekoshi, Ryo Numazawa, Yoshiyuki Horio. Resveratrol promotes autophagosome elimination via SIRT1 in cardiomyocytes. Journal of Pharmacological Sciences. 2024
  • Yuki Tatekoshi, Chunlei Chen, Jason Solomon Shapiro, Hsiang-Chun Chang, Malorie Blancard, Davi M Lyra-Leite, Paul W Burridge, Matthew Feinstein, Richard D'Aquila, Priscilla Hsue, et al. Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. eLife. 2024. 13
  • Gregory B. Waypa, Kimberly A. Smith, Paul T. Mungai, Vincent J. Dudley, Kathryn A. Helmin, Benjamin D. Singer, Clara Bien Peek, Joseph Bass, Lauren Nelson, Sanjiv J. Shah, et al. Mitochondria regulate proliferation in adult cardiac myocytes. Journal of Clinical Investigation. 2024. 134. 13
  • Yuki Toda, Sang-Bing Ong, Toshiyuki Yano, Atsushi Kuno, Hidemichi Kouzu, Tatsuya Sato, Wataru Ohwada, Yuki Tatekoshi, Toshifumi Ogawa, Masaki Shimizu, et al. Downregulation of Mitochondrial Fusion Protein Expression Affords Protection from Canonical Necroptosis in H9c2 Cardiomyoblasts. International Journal of Molecular Sciences. 2024. 25. 5. 2905-2905
  • Tetsuji Miura, Hidemichi Kouzu, Masaya Tanno, Yuki Tatekoshi, Atsushi Kuno. Role of AMP deaminase in diabetic cardiomyopathy. Molecular and Cellular Biochemistry. 2024
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MISC (34)：
  • 戸田 悠貴, 矢野 俊之, 久野 篤史, 丹野 雅也, 神津 英至, 佐藤 達也, 大和田 渉, 舘越 勇輝, 小川 俊史, 清水 将輝, et al. Impact of Mitochondrial Dynamics on Necroptosis in Cardiomyocytes(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ080-3
  • 齊藤 圭司, 細田 隆介, 嵯峨 幸夏, 舘越 勇輝, 久野 篤史. Administration of Nicotinamide Mononucleotide, a Precursor of NAD+, Attenuates Doxorubicin-induced Cardiotoxicity and Renal Tubular Injury in Mice(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ114-4
  • Paulina Stanczyk, Yuki Tatekoshi, Jason S Shapiro, Krithika Nayudu, Yihan Chen, Zachary Zilber, Matthew Schipma, Adam De Jesus, Amir Mahmoodzadeh, Ashley Akrami, et al. DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin depolymerization. bioRxiv : the preprint server for biology. 2023
  • 田中 仁啓, 舘越 勇輝, 藤本 恒, 夜久 英憲, カーン サディヤ, グリーンランド フィリップ. Temporal Trends in Mortality Attributable to Heart Failure between 2005 and 2019: Insights from Japanese Vital Statistics(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ54-5
  • Xiaoyan Yang, Hsiang-Chun Chang, Yuki Tatekoshi, Maryam Balibegloo, Rongxue Wu, Chunlei Chen, Tatsuya Sato, Jason Shapiro, Hossein Ardehali. SIRT2 inhibition protects against cardiac hypertrophy and heart failure. bioRxiv : the preprint server for biology. 2023
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Patents (1)：
  • Methods and compositions for treatment of heart failure with preserved ejection fraction
Lectures and oral presentations  (20)：
  • SNRKが制御するアクチン重合・DNA損傷・心筋肥大
    (UJA論文賞2024; オンライン授賞式 2024)
  • Protein O-GlcNAcylation in Endothelial Cells Drives the Development of Heart Failure with Preserved Ejection Fraction
    (The 88th Annual Scientific Meeting of the Japanese Circulation Society 2024)
  • UJA 留学のすゝめ2023 日本の科学技術を推進するネットワーク構築
    (第46回日本分子生物学会年会 2023)
  • A novel mechanism in the pathogenesis of heart failure with preserved ejection fraction through hexokinase mitochondrial dislocation and substrate shuttling into the O-GlcNAcylation machinery
    (American Heart Association Scientific Sessions 2022 2022)
  • Protein O-GlcNAcylation mediated by hexokinase mitochondrial localization underlies the pathogenesis of heart failure with preserved ejection fraction
    (Keystone symposia Heart failure: Mechanism and Therapies 2022)
ｍore...
Education (2)：
  • 2013 - 2017 Sapporo Medical University
  • 2005 - 2011 Sapporo Medical University
Professional career (1)：
  • 博士(医学) (札幌医科大学大学院医学研究科)
Work history (11)：
  • 2023/06 - 現在 札幌医科大学医学部 薬理学講座 助教
  • 2023/06 - 現在 札幌医科大学医学部 循環器・腎臓・代謝内分泌内科学講座 助教
  • 2018/10 - 2023/05 米国ノースウエスタン大学医学部 ファインバーグ心臓血管腎臓研究所 博士研究員
  • 2018/04 - 2018/09 北海道立江差病院 循環器内科 医長
  • 2017/04 - 2018/03 社会医療法人母恋 天使病院 循環器内科 診療医
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Committee career (3)：
  • 2023/08 - 現在 Under-45 International Society for Heart Research Section leader
  • 2021/07 - 2023/05 UJA論文賞ワーキンググループ イリノイ州チーフディレクター
  • 2021/07 - 2023/04 Northwestern University Japanese Researcher Association Organizer
Awards (5)：
  • 2024/05 - United Japanese Researchers Around the World UJA Outstanding Paper Award 2024 Special Award DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization
  • 2024/03 - The Japanese Circulation Society CPIS award Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction
  • 2022/11 - American Heart Association Scientific Session 2022 Best of AHA Specialty Conference: BCVS
  • 2016/08 - ESC congress 2016 (Rome) Best Poster Award
  • 2013/10 - 日本超音波医学会 第三回新人賞
Association Membership(s) (9)：
The Molecular Biology Society of Japan ,  日本薬理学会 ,  U-45 International Society for Heart Research ,  American Heart Association ,  日本心不全学会 ,  日本糖尿病学会 ,  International Society for Heart Research Japanese Section ,  日本内科学会 ,  日本循環器学会
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