Rchr
J-GLOBAL ID：202301012914454421
Update date: Sep. 26, 2024
Murase Hirotaka
ムラセ ヒロタカ | Murase Hirotaka
Affiliation and department：
Job title：
Assistant Professor
Research field (2)：
Bioorganic chemistry
, Pharmaceuticals - chemistry and drug development
Research keywords (4)：
small molecules
, functionality oligonucleotides
, organic chemistry
, Nucleic Acids Chemistry
Research theme for competitive and other funds (5)：
- 2024 - 2027 Basic research into nucleic acid drugs that induce readthrough by chemically modifying the adenosine at the premature termination codon
- 2023 - 2026 シトシンN4位の部位特異的アシル基修飾法の開発
- 2021 - 2025 Development of small molecule drugs for fragile X syndrome based on ligands that cooperatively accumulate on the CGG repeats.
- 2020 - 2023 Development of small molecular ligands that bind to repeat RNA and induce a conformational change of RNA higher-order structure
- 2018 - 2020 Development of the recognition molecules for pre-miRNA based on the hydrogen bonding
Papers (13)：
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Yuki Yoshida, Yushi Niimi, Daichi Fushihara, Hideo Katakura, Ryusuke Fukui, Hirotaka Murase, Fumiaki Tomoike, Fumitaka Hashiya, Tsutomu Murakami, Eiichi N. Kodama, et al. 2′-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants. Bioorganic & Medicinal Chemistry. 2024. 110. 117813
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Kohei Nomura, Kaoru Onda, Hirotaka Murase, Fumitaka Hashiya, Yukiteru Ono, Goro Terai, Natsuhisa Oka, Kiyoshi Asai, Daisuke Suzuki, Naho Takahashi, et al. Development of PCR Primer Enabling the Design of Flexible Sticky Ends for Efficient Concatenation of Long DNA Fragments. RSC Chemical Biology. 2024. 5. 360-371
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Fumi Nagatsugi, Ryosuke Nagasawa, Kazumitsu Onizuka, Kaoru Komatsu, Emi Miyashita, Hirotaka Murase, Kanna Ojima, Shunya Ishikawa, Mamiko Ozawa, Hirohide Saito. Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries. Communications Chemistry. 2023. 7, 98
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Fumitaka Hashiya, Hirotaka Murase, Akash Chandela, Haruka Hiraoka, Masahito Inagaki, Yuko Nakashima, Naoko Abe, Mayu Nakamura, Goro Terai, Yasuaki Kimura, et al. The Effect of γ Phosphate Modified Deoxynucleotide Substrates on PCR Activity and Fidelity. ChemBioChem. 2023. 24. e202200572
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Masahito Inagaki, Naoko Abe, Zhenmin Li, Yuko Nakashima, Susit Acharyya, Kazuya Ogawa, Daisuke Kawaguchi, Haruka Hiraoka, Ayaka Banno, Zheyu Meng, et al. Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures. Nature Communications. 2023. 14. 2657
ｍore...
MISC (3)：
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Shigeki Sasaki, Hirotaka Murase. Manipulating nucleic acids - regulation of gene expression through higher order structure and chemical modification. DDS. 2024. 39. 1. 53-62
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なし. 2022. 22. 177-185
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なし. Journal of the Japan Society of Nucleic Acids Chemistry. 2020. Vol. 4. 15-21
Lectures and oral presentations (95)：
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Improvement of siRNA target specificity with a new 2'-modified nucleoside analog
(第25回日本RNA学会年会 2024)
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PCR停止プライマーによるDNA連結法の開発とmRNAライブラリー構築への応用
(日本ケミカルバイオロジー学会 第18回年会 2024)
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Synthesis of cap-2-type mRNA based on PureCap method
(The 3rd Intertnaional Symposium on Biofunctional Chemistry (ISBC2024) 2024)
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Synthesis and Evaluation of Photolabile Selenium-Modified Nucleic Acid for Intracellular Gene Expression Switching
(The 3rd Intertnaional Symposium on Biofunctional Chemistry (ISBC2024) 2024)
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Large-scale analysis of small molecule-RNA interactions by barcode microarray method
(The 3rd Intertnaional Symposium on Biofunctional Chemistry (ISBC2024) 2024)
ｍore...
Education (3)：
- 2014 - 2017 Kyushu University Graduate School, Division of Pharmaceutical Sciences
- 2012 - 2014 Kyushu University Graduate School, Division of Pharmaceutical Sciences
- 2008 - 2012 Kyushu University Faculty of Pharmaceutical Science
Professional career (1)：
- Ph.D. (Kyushu University)
Work history (4)：
- 2023/04 - 現在 Sojo University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
- 2020/06 - 2023/03 Nagasaki International University Faculty of Pharmaceutical Science Researher Postdoc
- 2019/01 - 2020/05 Nagoya University Graduate School, Division of Pharmaceutical Sciences Researher Postdoc
- 2017/04 - 2018/12 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Researher Postdoc
Awards (1)：
- 2018/11 - The 45th international Symposium on Nucleic Acids Chemistry ISNAC Outstanding Oral Presentation Award for Young Scientist (Ohtsuka Award)
Association Membership(s) (3)：
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