Takahashi Kou

Affiliation and department：

Research field (4)： Pharmacology , Psychiatry , Neuroscience - general , Neuroanatomy and physiology

Research keywords (5)：ストレス , グリア , グルタミン酸トランスポーター , うつ病 , 創薬

Research theme for competitive and other funds (9)：

2022 - 2025 ヘモグロビン由来マリファナ様物質の脳内作用機序と社会性障害治療効果
2020 - 2023 グリア型グルタミン酸トランスポーター発現減少に起因するうつ症状の神経基盤の解明
2017 - 2021 Drug discovery research for novel anti-stress and antidepressant drugs targeting glutamate transporters
2010 - 2012 Prg1, regulated by MATH2, is an important factor for survival of neurons derived from neural stem cells
2010 - 2012 Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline

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Papers (25)：

Chiharu Hidaka, Shinichi Mitsui, Yoij Osako, Kou Takahashi, Kenjiro Tanaka, Kazunari Yuri. Differential brain expression pattern of Sez6 alternative splicing isoform with deleted transmembrane domain. Biochemical and biophysical research communications. 2022. 636. Pt 2. 128-132
Kenjiro Tanaka, Yoji Osako, Kou Takahashi, Chiharu Hidaka, Koichi Tomita, Kazunari Yuri. Effects of post-weaning social isolation on social behaviors and oxytocinergic activity in male and female rats. Heliyon. 2019. 5. 5. e01646
Kou Takahashi, Qiongman Kong, Yuchen Lin, Nathan Stouffer, Delanie A. Schulte, Liching Lai, Qibing Liu, Ling Chu Chang, Sky Dominguez, Xuechao Xing, et al. Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease. Journal of Experimental Medicine. 2015. 212. 3. 319-332
Qiongman Kong, Ling Chu Chang, Kou Takahashi, Qibing Liu, Delanie A. Schulte, Liching Lai, Brian Ibabao, Yuchen Lin, Nathan Stouffer, Chitra Das Mukhopadhyay, et al. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. Journal of Clinical Investigation. 2014. 124. 3. 1255-1267
Qiongman Kong, Kou Takahashi, Delanie Schulte, Nathan Stouffer, Yuchen Lin, Chien Liang Glenn Lin. Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus. Neurobiology of Disease. 2012. 47. 2. 145-154

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MISC (39)：

高橋弘. 精神科領域の用語解説アストロサイト. 分子精神医学. 2019. 19. 1. 42-44
高橋弘. グルタミン酸トランスポーター活性化化合物の創薬研究精神・神経疾患の克服に向けて. 昭和学士会雑誌. 2016. 76. 5. 674-674
高橋弘. 薬理系薬学精神・神経疾患に対するグルタミン酸トランスポーター活性薬の将来性. ファルマシア. 2016. 52. 6. 562-562
Kou Takahashi, Joshua B. Foster, Chien Liang Glenn Lin. Glutamate transporter EAAT2: Regulation, function, and potential as a therapeutic target for neurological and psychiatric disease. Cellular and Molecular Life Sciences. 2015. 72. 18. 3489-3506
岩井孝志, 斎藤顕宜, 山田美佐, 高橋弘, 橋本富男, 橋本恵理, 鵜飼渉, 齋藤利和, 山田光彦. 抗うつ薬関連遺伝子Rhotekinは神経分化を促進する. 国立精神・神経医療研究センター精神保健研究所年報. 2012. 25. 233-233

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Professional career (1)：

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