Kobayashi Hiroshi

コバヤシヒロシ | Kobayashi Hiroshi

Affiliation and department：
Job title： Associate Professor

Research field (1)： Hematology and oncology

Research keywords (1)： Hematopoietic stem cell

Research theme for competitive and other funds (7)：

2024 - 2027 Identification of mesenchyme-derived factors essential for maintenance of hematopoietic stem cell
2021 - 2024 Development of a method to induce maturation of fetal hematopoietic stem cells
2019 - 2021 Study on the mechanism of HSC aging through quiescence maintaining culture
2017 - 2019 Study of aged hematopoietic stem cells through single-cell RNA-sequencing
2016 - 2018 Identification and characterization of biological targets of chemical expander for hematopoietic stem cells

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Papers (37)：

Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Takayuki Morikawa, Shinya Fujita, Kotaro Shide, et al. SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production. Cell stem cell. 2024
Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shinya Fujita, Takayuki Morikawa, Shuhei Koide, et al. Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis. eLife. 2024
Takahito Iga, Hiroshi Kobayashi, Dai Kusumoto, Tsukasa Sanosaka, Nobuyuki Fujita, Ikue Tai-Nagara, Tomofumi Ando, Tomoko Takahashi, Koichi Matsuo, Katsuto Hozumi, et al. Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis. Nature Cell Biology. 2023. 25. 10. 1415-1425
Keiyo Takubo, Phyo Wai Htun, Takeshi Ueda, Yasuyuki Sera, Masayuki Iwasaki, Miho Koizumi, Kohei Shiroshita, Hiroshi Kobayashi, Miho Haraguchi, Shintaro Watanuki, et al. MBTD1 preserves adult hematopoietic stem cell pool size and function. Proceedings of the National Academy of Sciences. 2023
Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinpei Tamaki, Miho Haraguchi, Masamichi Yamamoto, Ayako Nakamura-Ishizu, Shinichiro Okamoto, et al. Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells. Experimental Hematology. 2023

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MISC (14)：

城下郊平, 小林央, 田久保圭誉. 造血幹細胞とミトコンドリア代謝. 再生医療. 2020. 19. 3. 234-238
綿貫慎太郎, 小林央, 田久保圭誉. 【酸素環境と臓器機能感知・応答のメカニズムから最新の酸素イメージングまで】酸素環境と造血幹細胞システム. 実験医学. 2020. 38. 9. 1436-1440
城下郊平, 小林央, 田久保圭誉. 【発達・加齢と血液疾患】造血幹細胞の加齢変化. 血液内科. 2019. 79. 3. 321-326
小林央, 田久保圭誉. 生存戦略としての休眠シグナル研究の最先端造血幹細胞の休眠状態を体外で誘導する. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [1S12m-04]
小林央, 田久保圭誉. 生存戦略としての休眠シグナル研究の最先端造血幹細胞の休眠状態を体外で誘導する. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [1S12m-04]

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Patents (1)：

造血幹細胞を維持培養するための培地、及びそれを用いた培養方法

Lectures and oral presentations (1)：

Ex vivo maintenance of hematopoietic stem cells and metabolic regulation
(2024)

Education (2)：

2010 - 2014 The University of Tokyo Graduate School of Medicine
2003 - 2007 The University of Tokyo Faculty of Medicine School of Medicine

Professional career (1)：

Ph.D (The University of Tokyo)

Work history (5)：

2024/04 - 現在 Tohoku University Graduate School of Medicine Associate Professor
2014/04 - 2023/03 National Center for Global Health and Medicine
2012/04 - 2014/03 Japan Society for the Promotion of Science
2009/04 - 2010/03 The University of Tokyo
2007/04 - 2009/03 The University of Tokyo Faculty of Medicine University Hospital

Association Membership(s) (2)：

日本血液学会 , 日本内科学会

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