Research theme for competitive and other funds (3):
2020 - 2025 転写と共役したヌクレオソーム再構築の分子メカニズムの解明
2018 - 2021 Cryo-EM structure analysis of transcription elongation complexes
2009 - 2011 真核生物のRNAポリメラーゼにおける転写開始/終結機構の分子的基盤の解明
Papers (27):
Heeyoun Bunch, Deukyeong Kim, Masahiro Naganuma, Reiko Nakagawa, Anh Cong, Jaehyeon Jeong, Haruhiko Ehara, Hongha Vu, Jeong Ho Chang, Matthew J Schellenberg, et al. ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes. Nature communications. 2023. 14. 1. 8341-8341
Munetaka Akatsu, Haruhiko Ehara, Tomoya Kujirai, Risa Fujita, Tomoko Ito, Ken Osumi, Mitsuo Ogasawara, Yoshimasa Takizawa, Shun-Ichi Sekine, Hitoshi Kurumizaka. Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. The Journal of biological chemistry. 2023. 299. 12. 105477-105477
Seiya Hirai, Tomoya Kujirai, Munetaka Akatsu, Mitsuo Ogasawara, Haruhiko Ehara, Shun-Ichi Sekine, Yasuyuki Ohkawa, Yoshimasa Takizawa, Hitoshi Kurumizaka. Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.8. Journal of biochemistry. 2023
Takumi Oishi, Suguru Hatazawa, Tomoya Kujirai, Junko Kato, Yuki Kobayashi, Mitsuo Ogasawara, Munetaka Akatsu, Haruhiko Ehara, Shun-Ichi Sekine, Gosuke Hayashi, et al. Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic acids research. 2023
Shun-ichi Sekine, Haruhiko Ehara, Tomoya Kujirai, Hitoshi Kurumizaka. Structural perspectives on transcription in chromatin. Trends in Cell Biology. 2023