NAKAMURA Yoshihide

ナカムラヨシヒデ | NAKAMURA Yoshihide

Affiliation and department：

Research field (1)： Cardiology

Research keywords (3)： ER stress , Ryanodine receptor (RyR2) , calcium

Research theme for competitive and other funds (2)：

2024 - 2027 Development of RyR2-targetting therapy for heart failure and arrhythmia
2022 - 2024 Development of a new treatment for pulmonary hypertension by controlling calmodulin

Papers (22)：

Takashi Nawata, Takeshi Honda, Akihiko Sakamoto, Hitoshi Uchinoumi, Takeshi Suetomi, Yoshihide Nakamura, Shunya Tsuji, Hiroki Sakai, Shigeki Kobayashi, Takeshi Yamamoto, et al. Role of type 2 ryanodine receptor stabilisation in autoimmune cell modulation. Advances in Rheumatology. 2024. 64. 1
縄田純也, 小林茂樹, 石川真帆, 中嶋佑輔, 久岡雅弘, 中村吉秀, 小室あゆみ, 石口博智, 福田昌和, 末冨建, et al. アミオダロン治療抵抗性の虚血性心疾患に合併した多形性心室頻拍ストームに対して、ダントロレンが有効であった2症例. 日本心臓病学会学術集会抄録. 2023. 71回. P-6
Junya Nawata, Takeshi Yamamoto, Shinji Tanaka, Yasutake Yano, Tomoyuki Uchida, Shohei Fujii, Yoshihide Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, et al. Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats. Biochemistry and biophysics reports. 2023. 34. 101449-101449
Shohei Fujii, Shigeki Kobayashi, Yaowei Chang, Junya Nawata, Ryosuke Yoshitomi, Shinji Tanaka, Michiaki Kohno, Yoshihide Nakamura, Hironori Ishiguchi, Takeshi Suetomi, et al. RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure. Journal of molecular and cellular cardiology. 2023. 178. 36-50
Riko Fujioka, Takeshi Yamamoto, Akihiro Maruta, Yoshihide Nakamura, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano. Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells. Biochemical and biophysical research communications. 2023. 652. 61-67

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MISC (15)：

内田智之, 小田哲郎, 山本健, 内海仁志, 末冨建, 中村吉秀, 藤井翔平, 縄田純也, 矢野泰健, 小林茂樹, et al. Impaired Calmodulin Binding Affinity to Ryanodine Receptor Drives Heart Failure with Preserved Ejection Fraction Progression(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. PJ015-6
藤井翔平, 小林茂樹, 矢野泰健, 内田智之, 常耀偉, 縄田純也, 中村吉秀, 末冨建, 内海仁志, 小田哲郎, et al. Stabilization of RyR2 with Dantrolene Treatment Prevents Ventricular Tachycardia and Left Ventricular Remodeling in Post Myocardial Infarction Mice(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. PJ015-7
藤井翔平, 小林茂樹, 常耀偉, 縄田純也, 田中慎二, 中村吉秀, 末冨建, 内海仁志, 小田哲郎, 山本健, et al. RyR2の4量体構造の安定化は心筋梗塞後マウスの予後を改善する(Stabilization of RyR2 Tetrameric Structure Improves Prognosis in Post Myocardial Infarction Mice). 日本循環器学会学術集会抄録集. 2022. 86回. PJ21-2
Uchida Tomoyuki, Oda Tetsuro, Suetomi Takeshi, Yamamoto Takeshi, Kobayashi Shigeki, Nakamura Yoshihide, Fujii Shohei, Uchinoumi Hitoshi, Tanaka Shinji, Nawata Jyunya, et al. 2型リアノジン受容体へのカルモジュリンの結合親和性の増強は左室駆出率が保たれた心不全の治療標的となり得る(Enhancing calmodulin binding affinity to ryanodine receptor type2 can be a therapeutic target for heart failure with preserved ejection fraction). 日本内分泌学会雑誌. 2022. 97. 5. 1492-1492
Fujii Shohei, Kobayashi Shigeki, Chang Yaowei, Nawata Jyunya, Tanaka Shinji, Nakamura Yoshihide, Suetomi Takeshi, Uchinoumi Hitoshi, Oda Tetsuro, Yamamoto Takeshi, et al. RyR2標的治療は心筋梗塞後の左室リモデリングを改善する(RyR2-targeting therapy improves left ventricular remodeling after myocardial infarction). 日本内分泌学会雑誌. 2022. 97. 5. 1493-1493

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Awards (11)：

2024/12 - BCVR Poster Award Concomitant administration of dantrolene is sufficient to protect against doxorubicin-induced cardiomyopathy
2024 - 日本学術振興会科研費(若手研究)
2024 - 公益財団法人榊原記念財団榊原記念研究助成
2023 - 新日本先進医療研究財団研究助成
2023 - 循環器病研究振興財団山内進循環器病研究助成

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