Rchr
J-GLOBAL ID：202301020903188617
Update date: Mar. 22, 2024
YAZAWA HANAKO
ヤザワ ハナコ | YAZAWA HANAKO
Affiliation and department：
Job title：
Lecturer
Research field (4)：
Experimental pathology
, Respiratory medicine
, Human pathology
, Tumor biology
Research keywords (8)：
肺癌
, 希少型肺腺癌
, 神経内分泌癌
, 小細胞肺癌
, リプログラミング
, 細胞分化
, 転写因子
, プロモーター
Research theme for competitive and other funds (14)：
- 2021 - 2024 Elucidation of molecular mechanism that endocrine secretory granule biogenesis
- 2021 - 2024 Molecular basis of tumorigenesis of pulmonary neuroendocrine cancer via REST and MYT1L
- 2021 - 2024 複数のクローディン分子連携による小細胞肺癌の悪性形質制御機構
- 2021 - 2024 Molecular basis of tumorigenesis in pulmonary adenocarcinomas of rare histologic types
- 2020 - 2023 Basic research to elucidate the occurrence of inhomogeneity of transpulmonary pressure and to establish an individual ventilatory strategy for different pathological lungs.
- 2018 - 2021 Molecular basis of neuroendocrine lung carcinogenesis in association with dysfunction of RB1-family proteins
- 2017 - 2020 Clarification of precondition causing direct reprogramming in lung cancer
- 2015 - 2019 Progressive multifocal leukoencephalopathy: Dynamics of PML-NBs of JC virus-infected glial cells
- 2015 - 2018 Establishment of novel therapeutic strategy against neuroendocrine lung cancer through regulation of malignant neural phenotype
- 2012 - 2015 Molecular pathological analyses of proneural/neuroendocrine phenotype-obtaining mechanisms on lung cancer cells
- 2010 - 2012 Analysis of expression mechanisms of cell adhesion molecules via malignant neuroendocrine tumor cell-specific transcription factors
- 2009 - 2011 Analysis of expression mechanisms of neuroendocrine cancer cell-specific molecules via TTF-1
- 2007 - 2008 Exhaustive search for onco-suppressor genes induced by Egr-1 and cause-analysis of their repression in association with carcinogenesis
- 2007 - 2008 Analysis of IGFBP-4/-2expression deficiency in association with cancer progression
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Papers (24)：
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Meitetsu Masawa, Hanako Sato-Yazawa, Korehito Kashiwagi, Jun Ishii, Chie Miyata-Hiramatsu, Masami Iwamoto, Kakeru Kohno, Tadasuke Miyazawa, Masato Onozaki, Shuhei Noda, et al. REST Inactivation and Coexpression of ASCL1 and POU3F4 Are Necessary for the Complete Transformation of RB1/TP53-Inactivated Lung Adenocarcinoma into Neuroendocrine Carcinoma. The American journal of pathology. 2022. 192. 6. 847-861
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Korehito Kashiwagi, Hanako Sato-Yazawa, Jun Ishii, Kakeru Kohno, Isaaki Tatsuta, Tadasuke Miyazawa, Megumi Takagi, Hideki Chiba, Takuya Yazawa. LXRβ Activation Inhibits the Proliferation of Small-cell Lung Cancer Cells by Depleting Cellular Cholesterol. Anticancer research. 2022. 42. 6. 2923-2930
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Jun Ishii, Hanako Sato-Yazawa, Korehito Kashiwagi, Kazuhiko Nakadate, Masami Iwamoto, Kakeru Kohno, Chie Miyata-Hiramatsu, Meitetsu Masawa, Masato Onozaki, Shuhei Noda, et al. Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX1. Journal of molecular histology. 2022. 53. 2. 437-448
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矢澤 華子, 石井 順, 矢澤 卓也. 【新型コロナウイルス感染症2019】新型コロナウイルスの変異とゲノム解析. Dokkyo Journal of Medical Sciences. 2021. 48. 3. 239-242
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Shotaro Matsudera, Hanako Sato-Yazawa, Misao Terada, Takeshi Yamaguchi, Yukiko Tani, Shun Watanabe, Korehito Kashiwagi, Jun Ishii, Yoshifumi Ito, Kei Ogino, et al. Histopathological evaluation of the effectiveness of oral Eppikajutsuto treatment for lymphatic malformation. Journal of pediatric surgery. 2021. 56. 9. 1668-1672
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MISC (67)：
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矢澤華子, 柏木維人, 石井順, 矢澤卓也. 肺癌におけるリプログラミング現象. 細胞. 2023. 55. 10. 789-793
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矢澤 華子, 柏木 維人, 石井 順, 河野 翔, 小野崎 聖人, 野田 修平, 金野 晃大, 宮澤 公輔, 矢澤 卓也. RB1/TP53不活化肺腺癌細胞はREST不活化と神経特異的転写因子共発現により神経内分泌癌に形質転換する. 日本内分泌学会雑誌. 2023. 98. 5. 1631-1631
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矢澤 華子, 柏木 維人, 石井 順, 河野 翔, 岩本 雅美, 小野崎 聖人, 野田 修平, 金野 晃大, 宮澤 公輔, 矢澤 卓也. RB1/TP53不活化肺腺癌細胞はREST不活化と神経特異的転写因子共発現により神経内分泌癌に形質転換する. 日本病理学会会誌. 2023. 112. 1. 247-247
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上村 任, 石原 拓実, 宮澤 公輔, 矢澤 華子, 石井 順, 河野 翔, 柏木 維人, 矢澤 卓也. 小細胞肺癌の新たな治療標的分子についての検討 LXRβの活性化は小細胞肺癌細胞の増殖を抑制する. Dokkyo Journal of Medical Sciences. 2022. 49. 2. 115-115
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正和 明哲, 矢澤 華子, 柏木 維人, 石井 順, 宮澤 公輔, 清水 泰夫, 仁保 誠治, 矢澤 卓也. 肺腺癌から神経内分泌癌への形質転換現象に関わる分子メカニズム. Dokkyo Journal of Medical Sciences. 2022. 49. 1. 56-56
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Books (2)：
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新医療秘書シリーズ2 改訂 基礎医学
建帛社 2022
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新医療秘書シリーズ基礎医学
建帛社 2013
Lectures and oral presentations (3)：
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Growth regulation via insulin-like growth factor binding protein-4 and -2 in lung epithelial cells and cancers
(12th World Conference on Lung Cancer 2007)
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Significant upregulation of insulin-like growth factor binding protein-4 and -2 by K-ras activation in pulmonary airway epithelial cells and cancers.
(10th World Congress on Lung Cancer 2003)
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Study of the differential expression of genes by DNA microarray in the cells after ras genes transfection.
(The 7th China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials & molecular Electronics 2000)
Education (1)：
- 2002 - 2006 Yokohama City University Graduate School of Medicine
Professional career (1)：
Work history (4)：
- 2017/07 - 現在 獨協医科大学医学部 病理学講座 講師
- 2006/10 - 2017/06 聖マリアンナ医科大学医学部 解剖学講座 助教
- 2006/10 - 2012 Yokohama City University
- 2006/04 - 2006/09 横浜市立大学大学院医学研究科 病態病理学 博士研究員
Committee career (1)：
Awards (1)：
- 2021/03 - 獨協国際医学教育研究財団 獨協国際医学教育研究財団賞
Association Membership(s) (4)：
日本解剖学会
, 日本臨床内分泌病理学会
, 日本癌学会
, 日本病理学会
