Rchr
J-GLOBAL ID：202401002547297529   Update date: Oct. 10, 2024

AIKAWA Haruo

アイカワ ハルオ | AIKAWA Haruo
Affiliation and department：
The University of Tokyo Graduate School of Science Department of Chemistry

About The University of Tokyo Graduate School of Science Department of Chemistry


Job title： Assistant Professor
Research field  (7)： Chemical biology ,  Bioorganic chemistry ,  Molecular biochemistry ,  Biochemistry ,  Synthetic organic chemistry ,  Organic functional materials ,  Composite materials and interfaces
Research keywords  (6)： Chemical Biology ,  Peptide Chemistry ,  Ribonuclease-targeting Chimera (RIBOTAC) ,  Nucleic Acid Chemistry ,  Helicene ,  Gold Catalyst
Research theme for competitive and other funds  (10)：
  • 2024 - 2028 (Development of N/C-terminal labeling methods of proteins for non-destructive sequencing)
  • 2014 - 2019 Chemical Biology Studies on Trinucleotide Repeat Disease using Repeat-Binding Molecules
  • 2013 - 2016 Development of new modification methods of peptide terminal using carbophilic Lewis acid and a new peptide isostere
  • 2012 - 2015 Development of early diagnostic methods for cancer tissue and metastasis utilizing bivalent GPCR ligands
  • 2011 - 2015 Synthesis of 8-substituted purine chemical library and riboswitch-reengineering
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Papers (28)：
  • Quentin M R Gibaut, Yoshihiro Akahori, Jessica A Bush, Amirhossein Taghavi, Toru Tanaka, Haruo Aikawa, Lucas S Ryan, Brian M Paegel, Matthew D Disney. Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion. Journal of the American Chemical Society. 2022. 144. 48. 21972-21979
  • Jessica A Bush, Samantha M Meyer, Rita Fuerst, Yuquan Tong, Yue Li, Raphael I Benhamou, Haruo Aikawa, Patrick R A Zanon, Quentin M R Gibaut, Alicia J Angelbello, et al. A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 48. e2210532119
  • Hafeez S Haniff, Xiaohui Liu, Yuquan Tong, Samantha M Meyer, Laurent Knerr, Malin Lemurell, Daniel Abegg, Haruo Aikawa, Alexander Adibekian, Matthew D Disney. A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype. Cell chemical biology. 2022. 29. 2. 300-311
  • Jessica A Bush, Haruo Aikawa, Rita Fuerst, Yue Li, Andrei Ursu, Samantha M Meyer, Raphael I Benhamou, Jonathan L Chen, Tanya Khan, Sarah Wagner-Griffin, et al. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models. Science translational medicine. 2021. 13. 617. eabd5991
  • Samantha M Meyer, Christopher C Williams, Yoshihiro Akahori, Toru Tanaka, Haruo Aikawa, Yuquan Tong, Jessica L Childs-Disney, Matthew D Disney. Small molecule recognition of disease-relevant RNA structures. Chemical Society reviews. 2020. 49. 19. 7167-7199
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MISC (65)：
  • LOH Nicholas Yi Bin, 相川春夫, 寺坂尚紘, 菅裕明. Discovery of Chemoselective Peptides for the Inhibition of an Immune Checkpoint Interaction via RaPID Selection. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
  • 村上寛樹, 寺坂尚紘, 相川春夫, 菅裕明. N-Terminal chemical modification of aminoacyl-tRNA and its application to in vitro translation system. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
  • 相川春夫, 寺坂尚紘, 寺坂尚紘. 多量体化人工抗体による,METを標的とした人工成長因子の創成. 金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的共同研究拠点. 2023. 2022
  • 相川春夫. microRNAおよびリピートRNAを標的としたRNA結合分子の創生とRNA分解分子への応用. 東京医科歯科大学生体材料工学研究所年報. 2023. 56
  • 相川春夫, 今井幹雄, 内田創太, 西尾聡一郎. 今,次世代創薬を語る 3 De novo環状ペプチド創薬からネオバイオロジクス創薬へ. 化学と工業. 2023. 76. 11
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Books (1)：
  • 最新ペプチド合成技術とその創薬研究への応用
    メディカルドゥ 2012 ISBN:9784944157518
Lectures and oral presentations  (18)：
  • 核酸やタンパク質結合分子開発のためのDNA/RNAディスプレイ法
    (第254回 IBBセミナー 2023)
  • (Development of RNA binding molecules targeting microRNA and repeat RNA and application to RNA degrading molecules)
    (2022)
  • 核酸の機能制御を目的とした分子探索~DNAやRNAを有機化合物として考える~
    (有用物質合成を加速する分子設計の新展開 2016)
  • Synthesis and evaluation of naphthyridine derivatives having amino sugar
    (2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) 2015)
  • (Exploration of RNA binding small molecules)
    (2015)
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Education (3)：
  • 2006 - 2009 Tohoku University Graduate School of Science Department of Chemistry
  • 2004 - 2006 Tohoku University Graduate School of Science Department of Chemistry
  • 2000 - 2004 Tohoku University Faculty of Science Department of Chemistry
Professional career (1)：
  • Ph.D. (Tohoku University)
Work history (7)：
  • 2022/10 - 現在 The University of Tokyo Graduate School of Mathematical Sciences Assistant Professor
  • 2022/08 - 2022/10 The University of Tokyo Graduate School of Science Project Assistant Professor
  • 2021/05 - 2022/09 The University of Tokyo Graduate School of Science Postdoctoral Researcher
  • 2018/03 - 2021/03 The Scripps Research Institute Postdoctoral Research Assosiate
  • 2013/08 - 2018/02 Osaka University The Institute of Scientific and Industrial Research Specially Appointed Assistant Professor
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Committee career (2)：
  • 2014/06 - 2014/06 日本ケミカルバイオロジー学会 第9回年会実行委員
  • 2013/06 - 2013/06 日本ケミカルバイオロジー学会 第8回年会実行委員
Awards (3)：
  • 2009/03 - 東北大学大学院理学研究科化学専攻 化学専攻賞
  • 2008/03 - 東北大学G-COE 東北大学G-COE 第一回国際シンポジウムポスターアワード
  • 2007/06 - 万有仙台シンポジウム組織委員会 第18回万有仙台シンポジウム BestPoster賞
Association Membership(s) (2)：
日本ケミカルバイオロジー学会 ,  日本化学会
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