shiba naoko

シバナオコ | shiba naoko

Affiliation and department：
Job title： Assistant Professor
Research theme for competitive and other funds (6)：

2023 - 2027 筋ジストロフィー心筋症に対するナトリウム利尿ペプチドによる新規治療法の開発
2020 - 2023 Elucidation of the Pathology of STIM1 Myopathy in Skeletal and Cardiac Muscles and Development of Therapeutic Approaches Using iPSCs
2018 - 2021 Development of DMD exon 3-9 skipping therapy using iPSc
2018 - 2021 Research on pathogenesis and development of therapies for cardiac failure using dystrophin-deficient-cardiomyocytes derived from DMD patients
2016 - 2019 Evaluation of reliability and sensitivity of a new 6-minute walk test and pitch-up method for neuromuscular dystrophy

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Papers (25)：

Hideki Kobayashi, Shugo Tohyama, Hajime Ichimura, Noburo Ohashi, Shuji Chino, Yusuke Soma, Hidenori Tani, Yuki Tanaka, Xiao Yang, Naoko Shiba, et al. Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids. Circulation. 2024. 150. 8. 611-621
Naoko Shiba, Xiao Yang, Mitsuto Sato, Shin Kadota, Yota Suzuki, Masahiro Agata, Kohei Nagamine, Masaki Izumi, Yusuke Honda, Tomoya Koganehira, et al. Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1. Molecular therapy. Nucleic acids. 2023. 34. 102060-102060
Yuki Tanaka, Shin Kadota, Jian Zhao, Hideki Kobayashi, Satomi Okano, Masaki Izumi, Yusuke Honda, Hajime Ichimura, Naoko Shiba, Takeshi Uemura, et al. Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin. Stem cell research & therapy. 2023. 14. 1. 240-240
Mitsuto Sato, Naoko Shiba, Daigo Miyazaki, Yuji Shiba, Akinori Nakamura. Restoring Dystrophin Expression with Duchenne Muscular Dystrophy Exon 45 Skipping in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Methods in molecular biology (Clifton, N.J.). 2023. 2587. 141-151
Hideki Kobayashi, Shugo Tohyama, Hideaki Kanazawa, Hajime Ichimura, Shuji Chino, Yuki Tanaka, Yota Suzuki, Jian Zhao, Naoko Shiba, Shin Kadota, et al. Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration. Journal of molecular and cellular cardiology. 2023. 174. 77-87

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MISC (86)：

柴直子, 高野亨子, 中嶋英子, 西岡誠, 矢部愛美, 福山哲広. 診断に苦慮したSjogren-Larsson症候群の兄弟例. 脳と発達. 2024. 56. Suppl. S272-S272
柴直子, 柴直子, 楊暁, 門田真, 鈴木陽太, 縣正大, 長峰広平, 佐藤充人, 中村昭則, 柴祐司. DMD遺伝子ABD1領域の変異による心筋症に対するエクソンスキッピング治療の検討. 日本再生医療学会総会(Web). 2024. 23rd
寺内昭子, 黒岩靖, 林田美江, 高松道生, 八木芳雄, 安河内聰, 柴直子. 筋ジストロフィー症における心筋障害三才山病院における診療経験から. 日本農村医学会雑誌. 2023. 72. Suppl.1. S23-S24
宮崎大吾, 佐藤充人, 柴直子, 吉沢隆浩, 中村昭則. 重症度の異なるエクソン欠失を持つベッカー型筋ジストロフィーマウスの表現型比較検討. 日本筋学会学術集会・筋ジストロフィー医療研究会合同学術集会プログラム・抄録集. 2023. 9回・10回. 86-86
鈴木陽太, 鈴木陽太, 柴直子, YANG Xiao, 門田真, 堀内哲吉, 柴祐司. iPS由来神経細胞を用いたCACNA1E遺伝子変異による発達性てんかん性脳症の病態解明. 日本再生医療学会総会(Web). 2023. 22nd

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Lectures and oral presentations (2)：

Ablation of MMP-9 promotes resolution of inflammation and regeneration by modulating chemotaxis in early stage but exacerbates fibrosis in late stage in mdx mice
(20th International Congress of The World Muscle Society 2015)
A Newly Developed Six-Minute Walking Test for Duchenne Muscular Dystrophy
(20th International Congress of The World Muscle Society 2015)

Education (1)：

1996 - 2002 Shinshu University School of Medicine

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