Rchr
J-GLOBAL ID:202401008781691158
Update date: Nov. 21, 2024
OKUMURA Katsuzumi
オクムラ カツズミ | OKUMURA Katsuzumi
Affiliation and department:
Job title:
Professor Emeritus/Visiting Professor
Research theme for competitive and other funds (36):
- 2021 - 2024 Elucidation of the construction principle of animal cell chromosomes and their control mechanism
- 2019 - 2023 Epigenome-wide association study of human intervertebral disc degeneration
- 2011 - 2015 Regulation of intranuclear arrangement of genes and construction of cells which highly express recombinant proteins
- 2011 - 2014 Basic study on the network of mRNA maturation process by analyzing diversified mRNA exporter.
- 2011 - 2012 Analysis of the molecular basis for mRNA dynamics in the nucleus using next generation sequencer and the function for the factor(s)of quality control.
- 2010 - 2012 General principle and importance of organization of chromosome structures during mammalian development and cell differentiation
- 2007 - 2008 動物細胞核内複製・転写時の高次クロマチンダイナミクス
- 2007 - 2008 脂肪組織由来幹細胞の分化に伴う核内染色体・クロマチン動態
- 2006 - 2008 Principle of organization of chromosome structures during mammalian development and cell differentiation
- 2005 - 2006 動物細胞核内複製・転写時の高次クロマチンダイナミクス
- 2004 - 2005 ゲノム機能の次世代への継承に必要なクロマチンドメイン構造とその確立
- 2003 - 2005 ゲノムのリプログラミングと染色体構築原理
- 2004 - 2004 ゲノム上の核マトリックス結合部位の網羅的解析とそのダイナミクス
- 2003 - 2004 RNA-FISH技術を用いた染色体機能異常症のための萌芽的診断法開発研究
- 2002 - 2004 Roles of regulation of DNA replication in genomic imprinting
- 1999 - 2003 真核細胞ゲノム上の複製ドメイン・レプリコンの複製機序の解明
- 2001 - 2001 動物ゲノムのレプリコン構造解明のためのDNA複製部位可視化法の開発
- 1999 - 2000 Analysis of Intranuclear Communication of Homologous Alleles of Imprinted Genes and Transgenes
- 1998 - 1998 染色体9p21異常 -癌にとっての両刃の剣-
- 1998 - 1998 FISHによるマルチレプリコンの複製開始制御機構解析法の確立
- 1998 - 1998 ヒト・ゲノムの機能的ドメイン構成の解析ならびにFISHの技術開発
- 1997 - 1998 Identification of Replication Units in Mammalian Genome by Fiber-FISH
- 1997 - 1997 統括して機能的制御を受けるゲノム領域の探索とその遺伝子群の同定
- 1996 - 1997 Methods to analyze nuclear organizition of mammalian chromosomes in interphase nuclei
- 1996 - 1996 統括して機能的制御を受けるゲノム領域の探索とその遺伝子群の同定
- 1996 - 1996 動物細胞に導入した巨大遺伝子領域の増幅・発現とその核内挙動の解析
- 1994 - 1995 Delineation of DNA Replication Timing within MHC Region by FISH
- 1993 - 1995 Domain Structure and Function of Gluoamylase
- 1994 - 1994 FISHによるヒトがん特異的微小欠失・増幅領域同定法の開発
- 1993 - 1993 動物細胞に導入したDNAの増幅と複製の解析
- 1992 - 1992 蛍光in situハイブリダイゼーション法のDNA複製系解析への導入
- 1992 - 1992 FISH法によるDNA複製開始領域の解析
- 1992 - 1992 FISH法による細胞に移入された染色体・遺伝子のDNA複製系の解析
- 1990 - 1991 The Role of Sugar Chains on the Protein Refolding
- 1989 - 1989 蛋白質チオール・ジスルフィド修飾酵素の機能解析とその遺伝子産物再賦活化法への活用
- 1986 - 1986 蛋白質機能の酵素的改変-プロテイン ジスルフィド・イソメラーゼの活用
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Papers (49):
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Liqing Zang, Kazuhiro Kagotani, Takuya Hayakawa, Takehiko Tsuji, Katsuzumi Okumura, Yasuhito Shimada, Norihiro Nishimura. The Hexane Extract of Citrus sphaerocarpa Ameliorates Visceral Adiposity by Regulating the PI3K/AKT/FoxO1 and AMPK/ACC Signaling Pathways in High-Fat-Diet-Induced Obese Mice. Molecules (Basel, Switzerland). 2023. 28. 24
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Takuya Hayakawa, Asahi Yamamoto, Taiki Yoneda, Sakino Hori, Nanami Okochi, Kazuhiro Kagotani, Katsuzumi Okumura, Shin-Ichiro Takebayashi. Reorganization of the DNA replication landscape during adipogenesis is closely linked with adipogenic gene expression. Journal of cell science. 2023. 136. 2
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Shin-Ichiro Takebayashi, Tyrone Ryba, Kelsey Wimbish, Takuya Hayakawa, Morito Sakaue, Kenji Kuriya, Saori Takahashi, Shin Ogata, Ichiro Hiratani, Katsuzumi Okumura, et al. The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases. Cells. 2021. 10. 2
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Takuya Hayakawa, Rino Suzuki, Kazuhiro Kagotani, Katsuzumi Okumura, Shin-Ichiro Takebayashi. Camptothecin-Induced Replication Stress Affects DNA Replication Profiling by E/L Repli-Seq. Cytogenetic and genome research. 2021. 161. 8-9. 437-444
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Hisashi Miura, Saori Takahashi, Takahiro Shibata, Koji Nagao, Chikashi Obuse, Katsuzumi Okumura, Masato Ogata, Ichiro Hiratani, Shin-Ichiro Takebayashi. Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing. Nature protocols. 2020. 15. 12. 4058-4100
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MISC (15):
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奥村 克純. 博士と自己研鑽. 化学と生物. 2023. 61. 6. 253-253
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染色体複製と高次エピゲノム. 2012. 31. 8. 909-916
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伊藤克, 籠谷和弘, 大見亮宏, 浅沼伸吾, 荒木裕子, 金岡秀明, 矢野竹男, 奥村克純, 西村訓弘. しょうが抽出物は骨芽細胞による石灰化を促進し,破骨細胞の成熟を抑制する. 日本食品科学工学会大会講演集. 2012. 59th
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奥村 克純. 特集 細胞核-構造と機能 8.その他 核内ゲノムダイナミクスの可視化. 生体の科学. 2011. 62. 5. 500-501
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奥村 克純. 特集 細胞核-構造と機能 3.核骨格 核マトリックスとゲノムダイナミクス. 生体の科学. 2011. 62. 5. 400-401
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Patents (2):
Education (3):
- 1985 - Kyoto University Graduate School of Agriculture
- 1980 - 1985 Kyoto University Graduate School of Agriculture Department of Food Science and Technology
- 1976 - 1980 Kyoto University Faculty of Agriculture Department of Food Science and Technology
Professional career (1):
Work history (10):
- 2022/04 - 現在 Mie University Professor Emeritus/Visiting Professor
- 2022/04 - 2023/03 Suzuka University of Medical Science
- 2019/04 - 2022/03 Mie University Graduate School of Bioresources Dean
- 2004/04 - 2022/03 Mie University Graduate School of Bioresources Professor
- 2007/04 - 2009/03 Mie University
- 1992/08 - 2004/03 Mie University Faculty of Bioresources Associate Professor
- 1994/04 - 1997/03 総合研究大学院大学国立遺伝学研究所 客員助教授(兼任)
- 1996/03 - 1996/09 Babraham Institute Visiting associate professor
- 1985/04 - 1992/07 Mie University Assistant Professor
- 1990/02 - 1991/08 Yale University School of Medicine Visiting assistant professor
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Awards (5):
- 2022/05 - Japanese Sciety of Food Chemistry The Excellent Paper Award Published in Japanese Journal of Food Chemistry and Safety The relationship between replication-dependent DNA hypomethylation and DNA damage caused by folate deficiency
- 2022/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry JSBBA Award for Senior Scientists
- 2018/06 - Japanese Sciety of Food Chemistry The Excellent Paper Award Published in Japanese Journal of Food Chemistry and Safety Hexane extract of raw ginger enhances adipocyte differentiation through its PPARgamma ligand activity on 3T3-L1 preadipocytes. Jpn J Food Chem Safty, 24(1): 16-24 (2017)
- 2008/10 - The Japanese Biochemical Society JB Award Development of a novel preparation method of recombinant proteoliposomes using baculovirus gene expression systems. J Biochem 144(6):763-770 (2008)
- 1996/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry JSBBA Award for Young Scientists
Association Membership(s) (6):
Japanese Sciety of Food Chemistry
, The Japanese Society for Epigenetics
, Japanese Association for Animal Cell Technology
, The Molecular Biology Society of Japan
, The Japanese Biochemical Society
, Japan Society for Bioscience, Biotechnology, and Agrochemistry
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