Miki Yoshimi

Research field (2)： Pharmaceuticals - health and biochemistry , Pathobiochemistry

Research keywords (1)：脂質生化学

Research theme for competitive and other funds (8)：

2024 - 2025 Possible analysis of P-LPE for a novel regulator of itch response
2022 - 2025 sPLA2の足場としての細胞外小胞とその生理的意義の解明
2019 - 2023 Elucidation of disease control mechanism by intestinal bacteria-host interactions through extracellular phospholipid metabolism
2016 - 2019 Extracellular lipid metabolism and skin diseases
2017 - 2018 Regulation of skin disease by sPLA2s

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Papers (33)：

Yoshitaka Taketomi, Takayoshi Higashi, Kuniyuki Kano, Yoshimi Miki, Chika Mochizuki, Shota Toyoshima, Yoshimichi Okayama, Yasumasa Nishito, Susumu Nakae, Satoshi Tanaka, et al. Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024. 57. 8. 1828-1847
Kai Kudo, Ryo Yanagiya, Masanori Hasegawa, Joaquim Carreras, Yoshimi Miki, Shunya Nakayama, Etsuko Nagashima, Yuji Miyatake, Kan Torii, Kiyoshi Ando, et al. Unique lipid composition maintained by extracellular blockade leads to prooncogenicity. Cell Death Discovery. 2024. 10. 1. 221-221
Asako Hamu-Tanoue, Koichi Takagi, Yoshitaka Taketomi, Yoshimi Miki, Yasumasa Nishito, Kuniyuki Kano, Junken Aoki, Takahiro Matsuyama, Kiyotaka Kondo, Yoichi Dotake, et al. Group III secreted phospholipase A2-driven lysophospholipid pathway protects against allergic asthma. The FASEB Journal. 2024. 38. 2. e23428
Haruka Hakoi, Yoshimi Miki, Saki Nomura, Kimiko Nakajima, Chiaki Terashima-Murase, Takuya Takeichi, Shigetoshi Sano, Masashi Akiyama, Shin-Ichi Sakasegawa, Makoto Murakami, et al. Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2. Biochimie. 2023. 215. 75-87
Akari Nakamura, Seiichiro Sakai, Yoshitaka Taketomi, Jun Tsuyama, Yoshimi Miki, Yuichiro Hara, Nobutaka Arai, Yuki Sugiura, Hideya Kawaji, Makoto Murakami, et al. PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke. Neuron. 2023. 111. 19. 2995-3010

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MISC (16)：

エスエム・カレドゥル・ラハマン, 佐々木すみれ, 宇山徹, ザヒル・フセイン, モハメッド・マムン・シクダル, 財賀大行, 星野真理, 太田健一, 三木寿美, 星野克明, et al. マウスにおけるphospholipase A and acyltransferase 1(PLAAT1)の欠損は高脂肪食誘導性の脂肪肝を改善させる. ビタミン. 2024. 98. 2. 65-69
Michihiro Takahama, Ashwini Patil, Katherine Johnson, Denis Cipurko, Yoshimi Miki, Yoshitaka Taketomi, Peter Carbonetto, Madison Plaster, Gabriella Richey, Surya Pandey, et al. Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation. bioRxiv : the preprint server for biology. 2023
Yoshitaka Taketomi, Yoshimi Miki, Makoto Murakami. Old but New: Group IIA Phospholipase A2 as a Modulator of Gut Microbiota. Metabolites. 2022. 12. 4
佐野有隆, 佐野有隆, 豊島翔太, 三木寿美, 李賢鎬, 李賢鎬, 菅順一郎, 菅順一郎, 柳澤正彦, 柳澤正彦, et al. 関節リウマチ患者の膝関節滑液中の脂質メディエーターの解析. 日本整形外科学会雑誌. 2021. 95. 8. S1649-S1649
岡山吉道, 佐野有隆, 豊島翔太, 三木寿美, 武富芳隆, 坂本朋美, 李賢鎬, 齋藤修, 村上誠, 田杭真帆, et al. Development of new therapeutic strategy and investigation of the pathogenesis of severe immunological and allergic diseases. 日本大学医学部総合医学研究所紀要(Web). 2020. 8. 42-48

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Patents (3)：

Lectures and oral presentations (137)：

Novel acetal-type lysoplasmalogen, a secondary product of group IIF phospholipase A2, promotes skin wound healing
(The 64th International Conference on the Bioscience of Lipids (ICBL2024) 2024)
Role of the group IIF phospholipase A2/lysoplasmalogen pathway in atopic dermatitis
(The 64th International Conference on the Bioscience of Lipids (ICBL2024) 2024)
PLAAT5は精巣において抗炎症性N-アシルエタノールアミンの生合成を担う
(日本ビタミン学会第75回大会 2024)
アセタール型リゾプラズマローゲンは創傷治癒を促進する
(第66回日本脂質生化学会 2024)
PLAAT5によって合成されるN-アシルエタノールアミンは精巣炎を緩和する
(第66回日本脂質生化学会 2024)

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Awards (5)：

2012 - 新学術領域生命応答を制御する脂質マシナリー若手ワークショップ, 優秀賞
2012 - 平成24年度東京都医学総合研究所ポスター発表会, 優秀賞
2012 - 第85回日本生化学会, 鈴木紘一メモリアル賞
2011 - 第10回次世代を担う若手ファーマ・バイオフォーラム, 優秀発表賞
2010 - 平成22年度東京都臨床医学総合研究所ポスター発表会, 優秀賞

Association Membership(s) (2)：

日本脂質生化学会 , 日本生化学会

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