Hiroshi Ikeuchi, Yusuke Matsuno, Rika Kusumoto-Matsuo, Shinya Kojima, Toshihide Ueno, Masachika Ikegami, Rina Kitada, Hitomi Sumiyoshi-Okuma, Yuki Kojima, Kan Yonemori, et al. GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway. Oncogene. 2024
Shinji Kohsaka, Shigehiro Yagishita, Yukina Shirai, Yusuke Matsuno, Toshihide Ueno, Shinya Kojima, Hiroshi Ikeuchi, Masachika Ikegami, Rina Kitada, Ken-ichi Yoshioka, et al. A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. npj Precision Oncology. 2024. 8. 1
Yuya Manaka, Rika Kusumoto-Matsuo, Yusuke Matsuno, Haruka Asai, Ken-Ichi Yoshioka. Single base substitution signatures 17a, 17b, and 40 are induced by γ-ray irradiation in association with increased reactive oxidative species. Heliyon. 2024. 10. 6. e28044
Mafuka Suzuki, Haruka Fujimori, Kakeru Wakatsuki, Yuya Manaka, Haruka Asai, Mai Hyodo, Yusuke Matsuno, Rika Kusumoto-Matsuo, Mitsunori Shiroishi, Ken-Ichi Yoshioka. Genome destabilization-associated phenotypes arising as a consequence of therapeutic treatment are suppressed by Olaparib. PloS one. 2023. 18. 1. e0281168
Yusuke Matsuno, Rika Kusumoto-Matsuo, Yuya Manaka, Haruka Asai, Ken-Ichi Yoshioka. Echoed induction of nucleotide variants and chromosomal structural variants in cancer cells. Scientific reports. 2022. 12. 1. 20964-20964
Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and clonal evolution
(The 12th 3R+3C International Symposium 2024)
Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution
(The 67th Annual Meeting of the Japanese Radiation Research Society 2024)
Single Base Substitution Signatures 17a, 17b, and 40 Are Induced by g-Ray Irradiation in Association with Increased ROS
(The 83nd Annual Meeting of the Japanese Cancer Association 2024)
Echoed Induction of Nucleotide Mutations and Chromosomal Structural Variants in Cancer Cells
(The 66th Annual Meeting of Japanese Radiation Research Society 2023)
Mechanistic study of genomic destabilization and mutation induction in cancer driver genes
(The 82nd Annual Meeting of the Japanese Cancer Association 2023)
2019 - 2022 Tokyo University of Science Graduate School of Science Department of Chemistry
2017 - 2019 Tokyo University of Science Graduate School of Science Department of Chemistry
2013 - 2017 Tokyo University of Science Faculty of Science, Division 1 Department of Chemistry
Professional career (2)：
Ph.D. (Tokyo University of Science)
M.Sc. (Tokyo University of Science)
Work history (3)：
2022/04 - 現在 Japan Society for the Promotion of Science Research Fellow (PD)
2022/04 - 現在 National Cancer Center Laboratory of Genome Stability Maintenance, Research Institute Research Fellow
2021/04 - 2022/03 Japan Society for the Promotion of Science Research Fellow (DC2)
Awards (3)：
2023/09 - The Japanese Cancer Association The Young Investigator Awards Mechanistic study of genomic destabilization and mutation induction in cancer driver genes
2019/09 - National Cancer Center Research Institute Director's Award Replication Stress Arisen by Radiation Leads to Genomic Destabilization and Clonal Evolution of Cells Abrogated their Defense Systems
2019/02 - National Cancer Center Research Institute Director's Award Replication stress triggers microsatellite destabilization and hypermutation, leading to clonal evolution
Association Membership(s) (3)：
The Japanese Radiation Research Society
, The Japanese Cancer Association
, The Molecular Biology Society of Japan
