Matsushita Takuya

2019 - 2023 A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression

2017 - 2023 Attempt to elucidate the pathological mechanisms of myasthenic crisis

2019 - 2022 Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies

2019 - 2022 Development of treatment for multiple sclerosis based on rice consumption, a newly identified environmental risk factor

2019 - 2022 Elucidation and Prevention of Progressive Multifocal Leukoencephalopathy Induced by Disease-Modifying Drugs in Japanese Patients with Multiple Sclerosis

2018 - 2021 Parent-of-origin effect in multiple sclerosis susceptibility

2016 - 2019 Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.

2015 - 2018 Therapy for multiple sclerosis targeting gamma-delta T cells and innate immunity based on genome-wide association studies in Japanese population

2015 - 2018 Retro-element insertion polymorphism in pathogenic Th17 cells specific for multiple sclerosis and its action

2013 - 2018 Elucidasion of functional contribution of glial dysturbances in pathomechanisms of demyelinating diseases and schizophrenia and development of new therapeutic options

2015 - 2017 Development of a novel treatment strategy based on the mechanisms that pathogenic T cells induce loss of glial connexins in CNS demyelinating disorders

2013 - 2016 connexin cytopathy in the pathogenesis of demyelinating disorders

2013 - 2015 Developing a cell transplantation therapy for chronic multiple sclerosis by using Schwann cells induced from mesenchymal stem cells

2010 - 2013 CIDPにおける膜蛋白質を標的としたantigen microarray解析

2011 - 2013 Macrophage function and polymorphism of PKCeta in neuromyelitis optica and multiple sclerosis

2011 - 2012 Connexin astrocytopathy in the pathogenesis of demyelination in concentric sclerosis and multiple sclerosis

2010 - 2012 Development of molecular targeted therapy of multiple sclerosis on the basis of membrane protein microarray analysis and gene interactions

2009 - 2011 Analysis of autoimmune response to claudin-family proteins in demyelinating disease.

2009 - 2010 A mechanisms of composing anti-aquaporin-4 antibody and the association with bacterial infection.