Rchr

J-GLOBAL ID：200901000072963022 Update date: Nov. 18, 2024

TAKAHIRO OCHIYA

オチヤタカヒロ | TAKAHIRO OCHIYA

Affiliation and department：
Job title：教授
Other affiliations (1)：

National Cancer Center, Research Institute

Homepage URL (1)： http://tokyo-med-mcm.jp

Research field (1)： Medical biochemistry

Research keywords (6)：発生工学 , 分子生物学 , 遺伝子治療学 , 分子腫瘍学 , 細胞工学 , Molecular & Cellular Biology

Research theme for competitive and other funds (36)：

2022 - 2026 変形性関節症に対する間葉系間質細胞由来セクレトーム治療における作用機序の解明
2022 - 2025 破骨細胞由来エクソソーム解析による薬剤関連顎骨壊死発症メカニズム解明への挑戦
2020 - 2025 Decipher cell-cell interactions
2020 - 2025 Maximum accuracy and application of diagnostic performance by integrated analysis of cancer exosome antigen and internal RNA information
2021 - 2024 Transporter-targeted drug development against urological cancers by utilizing liquid biopsy and AI

2020 - 2023 Establishment of aminoacid transporter directed prostate cancer therapy based on the liquid biopsy

2020 - 2023 A Study on Signal Transductions of MSC Culture in Total Autologous Angiogenic Therapy

2019 - 2023 Exploration of diagnostic and therapeutic biomarkers in primary central nervous system lymphoma

2020 - 2022 Single-cell analysis for the study of breast cancer metastasis

2019 - 2022 Development of a safe and efficient methods for the collection of mesenchymal stem cell-derived extracellular vesichles for the treatment of osteoarthritis

2015 - 2020 Achievement of highly accurate diagnosis of early pancreatic cancer in Japanese patients through a comprehensive/integrated approach

2016 - 2018 Generation of hepatic progenitor cells from human hepatocytes using small molecules

2015 - 2018 The elucidation of the molecular mechanism about the acquisition of pancreatic cancer invasion ability and application to cancer therapy

2014 - 2017 Development of biomarkers and novel therapeutic targets for malignant bone and soft tissue tumors using the methods of global expression analysis

2013 - 2015 Inhibition of microRNA functions by novel nucleic acids, iMIR

2012 - 2014 Development of novel cancer specific DDS utilizing circulating microRNA-derived mechanism

2011 - 2014 Development of novel cancer therapy using miRNA containing exosome

2011 - 2014 Mechanism of senescence-associated microRNA inhibiting cell growth and metastasis

2010 - 2014 Search for novel biomarkers and therapeutic targets of malignant bone and soft tissue tumors/sarcomas using the methods of global expression analysis

2011 - 2013 Why methylation and demethylation occur simultaneously in cancers

2010 - 2012 Integrated in vit-roin vivo organization of liver tissues having a functional bile duct network

2011 - 2011 Development of novel drug delivery system for micro RNA nucleic biomedicine using exosome from human cultured cells

2008 - 2011 Approach to Molecular Development of the Drug that induces Mitotic Catastrophe in Cancer cells

2008 - 2009 マイクロアレイによる肺癌のメチル化網羅的解析と診断・治療のターゲットの検討

2005 - 2009 Atelocollagen-mediated delivery of nucleic acid medicines

2007 - 2008 Establishing a new therapeutic strategy for liver failure by recycling phlebotomized blood cells

2007 - 2008 Development and application of functionalized nanocapsules

2000 - 2004 アテロコラーゲン包埋法の応用

1997 - 1999 c-Ha-rasトランスジェニックラットの発がん感受性の解析

1990 - 1990 B型肝炎ウイルスの増殖に関わる因子の研究

1988 - 1990 Studies on the Mechanism of Infection and Replication of Hepatitis B Virus

1989 - 1989 B型肝炎ウイルスの増殖・組込みと肝癌発生との関連

1989 - 1989 肝炎ウイルスと肝癌発生

1988 - 1988 肝炎ウイルスと肝癌発生

1.幹細胞の増殖分化 2.遺伝子改変動物によるがん関連遺伝子の機能解析 3.バイオマテリアルによる遺伝子デリバリー技術の開発

1.Hepatic stem cell differentiation 2.Genetic animal models for cancer genomics 3.Biomaterial-based novel gene transfer technology

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Papers (683)：

Yuka Terada, Kumi Obara, Yusuke Yoshioka, Takahiro Ochiya, Haruhiko Bito, Kunihiro Tsuchida, Hiroshi Ageta, Natsumi Ageta-Ishihara. Intracellular dynamics of ubiquitin-like 3 visualized using an inducible fluorescent timer expression system. Biology open. 2024. 13. 11
Takao Yasui, Atsushi Natsume, Takeshi Yanagida, Kazuki Nagashima, Takashi Washio, Yuki Ichikawa, Kunanon Chattrairat, Tsuyoshi Naganawa, Mikiko Iida, Yotaro Kitano, et al. Early Cancer Detection via Multi-microRNA Profiling of Urinary Exosomes Captured by Nanowires. Analytical chemistry. 2024
Koji Uotani, Tomohiro Fujiwara, Koji Ueda, Aki Yoshida, Shintaro Iwata, Takuya Morita, Masahiro Kiyono, Toshiyuki Kunisada, Ken Takeda, Joe Hasei, et al. Identification of ENO-1 positive extracellular vesicles as a circulating biomarker for monitoring of Ewing sarcoma. Cancer science. 2024
Tomohiro Umezu, Tomoya Mori, Hidenori Toyoda, Kohsuke Kanekura, Akihiro Tamori, Takahiro Ochiya, Masahiko Kuroda, Tatsuya Akutsu, Yoshiki Murakami. Analysis of Carcinogenic Involvement of MicroRNA Pattern in Peripheral Non-Cancerous Tissues and Chronic Viral Liver Injury. International journal of molecular sciences. 2024. 25. 14
Daisuke Miyamoto, Kunihito Matsuguma, Kazuhiro Nagai, Takayuki Miyoshi, Takanobu Hara, Hajime Matsushima, Akihiko Soyama, Takahiro Ochiya, Yasushi Miyazaki, Susumu Eguchi. Efficacy of chemically induced human hepatic progenitor cells from diseased liver against nonalcoholic steatohepatitis model. Journal of hepato-biliary-pancreatic sciences. 2024

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MISC (344)：

小林美穂, 藤原花汐, 高橋和樹, 高橋和樹, 吉岡祐亮, 落谷孝広, 井上カタジナアンナ, 渡部徹郎. Endothelial destabilization by tumor-derived exosome. リンパ学. 2023. 46. 1. 7-12
檀裕治, 松崎潤太郎, 藤田雄, 山口智子, 及川千尋, 落谷孝広, 齋藤義正. Distinct intercellular trafficking of COPB2 in lung cancer cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
山元智史, 中山淳, 落谷孝広, 山本雄介. Alteration of Drug Sensitivity and Metastatic Ability with Human Plasma-Like Medium Culture in Breas. 日本がん転移学会学術集会・総会プログラム抄録集. 2023. 32nd
松崎潤太郎, 津川仁, 中山淳, 山本雄介, 加藤健, 大田信行, 大嶋一輝, 勝田菜友, 吉岡祐亮, 落谷孝広, et al. 加齢による腸内細菌-宿主応答の変化に注目した新規発がんリスクバイオマーカーの探索. がん予防学術大会プログラム・抄録集. 2023. 2023
Tomofumi Yamamoto, Takayuki Mizutani, Yusuke Yoshioka, Takahiro Ochiya. Aberrant Serine Metabolism Promotes Bone metastasis via Extracellular Vesicles Secretion. CANCER SCIENCE. 2022. 113. 1407-1407

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Books (5)：

改訂第3版「バイオ実験の進め方」佐々木博己(編)
羊土社 2007 ISBN:9784897069234
バイオテクノロジージャーナル「生きた細胞を自在に操るテクノロジーレーザー技術が拓くナノバイオの新しい世界」
羊土社 2005 ISBN:9784897061627
実験法Q&Aシリーズ「遺伝子導入なるほどQ&A」落谷孝広(編) 青木一教(編)
羊土社 2005 ISBN:9784897064819
Antisense approaches to in vitro organ culture., T. Ochiya and M. Terada
ANTISENSE TECHNOLOGY Methods in Enzymology, 314: 401-411 (1999).
Antisense approaches to in vitro organ culture. T. Ochiya and M. Terada ANTISENSE TECHNOLOGY
ANTISENSE TECHNOLOGY Methods in Enzymology, 314: 401-411 (1999).

Professional career (1)：

Ph.D.

Work history (12)：

2019 - 現在 National Cancer Center, Research Institute
2018 - 現在 Tokyo Medical University
2018 - 2019 国立がん研究センター研究所分子細胞治療研究分野プロジェクトリーダー
2010 - 2018 National Cancer Center, Research Institute
1998 - 2010 国立がんセンター研究所がん転移研究室室長

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Committee career (1)：

2002 - 日本癌学会評議員

Awards (8)：

2019 - 高松宮妃癌研究基金学術賞
2019 - ISEV (The International Society for Extracellular Vesicles) Special Achievement Award
2019 - 文部科学省ナノテクノロジープラットフォーム「秀でた利用成果」優秀賞
2007 - 第5回IFAT国際会議学会賞
2006 - 日本人工臓器学会オリジナル賞

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Association Membership(s) (9)：

Japan Society for Extracellular Vesicles , 日本分子生物学会 , 日本生化学会 , 日本癌学会 , 日本遺伝子治療学会 , The Molecular Biology Society of JAPAN , The Japanese Biochemical Society , The Japan Society of Gene Therapy , Japanese Cancer Association

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