Research keywords (7)：
タンパク質N-ミリストイル化
, タンパク質プレニル化
, comprehensive analysis
, cell-free protein synthesis system
, protein S-palmitoylaton
, lipid modification of protein
, posttranslational modification of protein
Research theme for competitive and other funds (16)：
2020 - 2023 N-ミリストイル化された膜タンパク質の発見とその機能発現機構の解明
2017 - 2020 Analysis of novel regulatory mechanisms of membrane proteins mediated by protein N-myristoylation
2014 - 2017 The search for novel biomarkers by comprehensive identification of human lipid modified proteins
2011 - 2013 The search for novel biomarkers by comprehensive identification of human N-myristoylated proteins
2008 - 2010 Analysis of novel regulatory mechanism of apoptosis mediated by the posttranslational N-myristoylation of protein
2005 - 2006 A novel mechanism for the regulation of cellular apoptosis mediated by posttranslational N-myristoylation of cytoskeletal proteins.
2003 - 2004 Establishment of methods for prediction of the function of functionally-unknown gene products by the analysis of the posttranslational protein modifications.
2000 - 2001 Molecular mechanism of cellular processing of transmembrane tumor necrosis factor
1998 - 1999 Molecular mechanism of cellular processing of tumor necrosis factor (TNF)
1996 - 1996 蛋白質イソプレニル化シグナルの導入による膜局在性酸素製剤の開発
1994 - 1995 Preparation and characterization of an N-myristoylated fusion protein that binds to the membrane surface
Haruna Harada, Koko Moriya, Hirotsugu Kobuchi, Naotada Ishihara, Toshihiko Utsumi. Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7. Scientific Reports. 2023. 13. 22991
Takuya Teshima, Risa Funai, Takehito Nakazawa, Junya Ito, Toshihiko Utsumi, Pattana Kakumyan, Hiromi Mukai, Toyoshi Yoshiga, Ryutaro Murakami, Kiyotaka Nakagawa, et al. Coprinopsis cinerea dioxygenase is an oxygenase forming 10(S)-hydroperoxide of linoleic acid, essential for mushroom alcohol, 1-octen-3-ol synthesis. The Journal of Biological Chemistry. 2022. 298. 11. 102507-102507
Toshihiko Utsumi, Takuro Hosokawa, Mayu Shichita, Misato Nishiue, Natsuko Iwamoto, Haruna Harada, Aya Kiwado, Manami Yano, Motoaki Otsuka, Koko Moriya. ANKRD22 is an N-myristoylated hairpin-like monotopic membrane protein specifically localized to lipid droplets. Scientific Reports. 2021. 11. 1
Emiko Kinoshita-Kikuta, Toshihiko Utsumi, Aya Miyazaki, Chiharu Tokumoto, Kyosuke Doi, Haruna Harada, Eiji Kinoshita, Tohru Koike. Protein-N-myristoylation-dependent phosphorylation of serine 13 of tyrosine kinase Lyn by casein kinase 1γ at the Golgi during intracellular protein traffic. Scientific Reports. 2020. 10. 1. 16273
HIRAKURA Setsuko, SAITO Shigeru, OZOE Yoshihisa, UTSUMI Toshihiko. Study on pyridalyl, a novel insecticide (Part V) : Effects of pyridalyl on cultured insect and mammalian cells. 2005. 30. 46-46
UTSUMI Toshihiko. Molecular mechanism for the cellura processing of TNF-_α. 1999. 57. 5. 39-40
