Research keywords (7):
タンパク質N-ミリストイル化
, タンパク質プレニル化
, comprehensive analysis
, cell-free protein synthesis system
, protein S-palmitoylaton
, lipid modification of protein
, posttranslational modification of protein
Research theme for competitive and other funds (16):
2020 - 2023 N-ミリストイル化された膜タンパク質の発見とその機能発現機構の解明
2017 - 2020 タンパク質N-ミリストイル化を介した膜タンパク質の新たな機能制御機構の解明
2014 - 2017 The search for novel biomarkers by comprehensive identification of human lipid modified proteins
2011 - 2013 The search for novel biomarkers by comprehensive identification of human N-myristoylated proteins
2008 - 2010 Analysis of novel regulatory mechanism of apoptosis mediated by the posttranslational N-myristoylation of protein
2005 - 2006 A novel mechanism for the regulation of cellular apoptosis mediated by posttranslational N-myristoylation of cytoskeletal proteins.
2003 - 2004 Establishment of methods for prediction of the function of functionally-unknown gene products by the analysis of the posttranslational protein modifications.
2000 - 2001 Molecular mechanism of cellular processing of transmembrane tumor necrosis factor
1998 - 1999 Molecular mechanism of cellular processing of tumor necrosis factor (TNF)
1996 - 1996 蛋白質イソプレニル化シグナルの導入による膜局在性酸素製剤の開発
1994 - 1995 Preparation and characterization of an N-myristoylated fusion protein that binds to the membrane surface
Kinoshita-Kikuta E, Tanikawa A, Hosokawa T, Kiwado A, Moriya K, Kinoshita E, Koike T, Utsumi T. A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE. PLOS ONE. 2019. 14. 11. e0225510
Utsumi T, Matsuzaki K, Kiwado A, Tanikawa A, Kikkawa Y, Hosokawa T, Otsuka A, Iuchi Y, Kobuchi H, Moriya K. Identification and characterization of protein N-myristoylation occurring on four human mitochondrial proteins, SAMM50, TOMM40, MIC19, and MIC25. PloS one. 2018. 13. 11. e0206355