Rchr
J-GLOBAL ID:200901000159559910   Update date: Jul. 05, 2020

Takeuchi Hideyuki

タケウチ ヒデユキ | Takeuchi Hideyuki
Affiliation and department:
Research field  (4): Cell biology ,  Functional biochemistry ,  Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (12): Glycoproteomics ,  Quality control ,  Folding ,  EGF repeats ,  O-Glycans ,  O-Glucosylation ,  Mass spectrometry ,  Glycosyltransferase ,  Notch signaling ,  Biochemistry ,  Glycobiology ,  Cancer Biology
Research theme for competitive and other funds  (4):
  • 2019 - 2022 Significance of structural diversity of O-glucose glycans in Notch signaling
  • 2009 - 2011 Significance of novel specificity of Rumi in notch signaling
  • Variety of mncin glycosylation and its biological iole
  • Analysis of Function and Transcriptional Regulation of MUC1 Mucin
Papers (54):
  • Mitsutaka Ogawa, Yuko Tashima, Yamato Sakaguchi, Hideyuki Takeuchi, Tetsuya Okajima. Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking. Biochemical and biophysical research communications. 2020. 526. 1. 184-190
  • Yusuke Urata, Wataru Saiki, Yohei Tsukamoto, Hiroaki Sago, Hideharu Hibi, Tetsuya Okajima, Hideyuki Takeuchi. Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking. Cells. 2020. 9. 5. 1220-1220
  • Sayad Md Didarul Alam, Yohei Tsukamoto, Mitsutaka Ogawa, Yuya Senoo, Kazutaka Ikeda, Yuko Tashima, Hideyuki Takeuchi, Tetsuya Okajima. N-glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization. The Journal of biological chemistry. 2020
  • E. Servián-Morilla, M. Cabrera-Serrano, K. Johnson, A. Pandey, A. Ito, E. Rivas, T. Chamova, N. Muelas, T. Mongini, S. Nafissi, K. G. Claeys, R. P. Grewal, M. Takeuchi, H. Hao, C. Bönnemann, O. Lopes Abath Neto, L. Medne, J. Brandsema, A. Töpf, A. Taneva, J. J. Vilchez, I. Tournev, R. S. Haltiwanger, H. Takeuchi, H. Jafar-Nejad, V. Straub, Carmen Paradas. POGLUT1 biallelic mutations cause myopathy with reduced satellite cells, α-dystroglycan hypoglycosylation and a distinctive radiological pattern. Acta Neuropathologica. 2020. 139. 3. 565-582
  • Yusuke Urata, Hideyuki Takeuchi. Effects of Notch glycosylation on health and diseases. Development, Growth & Differentiation. 2020. 62. 1. 35-48
more...
MISC (18):
  • TAKEUCHI Hideyuki. Notch-Modifying Protein O-Glucosyltransferase 1 (POGLUT1): Specificities, Structures, and Human Disease Implications. Trends in Glycoscience and Glycotechnology. 2019
  • Hideyuki Takeuchi, Hongjun Yu, Megumi Takeuchi, Atsuko Ito, Huillin Li, Robert S. Haltiwanger. Structural and biochemical analyses suggest that O-fucose and O-glucose glycans modulate protein folding and flexibility of EGF repeats. GLYCOBIOLOGY. 2016. 26. 12. 1420-1421
  • Robert S. Haltiwanger, Hongjun Yu, Megumi Takeuchi, Jamie LeBarron, Joshua Kantharia, Erwin London, Hans Bakker, Huilin Li, Hideyuki Takeuchi. Regulation of Notch signaling by O-glucosylation: Notch-modifying xylosyltransferase-substrate complexes support an S(N)i-like retaining mechanism. FASEB JOURNAL. 2016. 30
  • Robert S. Haltiwanger, Hongjun Yu, Megumi Takeuchi, Jamie LeBarron, Joshua Kantharia, Erwin London, Hans Bakker, Huilin Li, Hideyuki Takeuchi. Regulation of Notch signaling by O-glucosylation: Notch-modifying xylosyltransferase-substrate complexes support an S(N)i-like retaining mechanism. FASEB JOURNAL. 2016. 30
  • Michael A. Schneider, Hideyuki Takeuchi, Peng Wu, Robert Haltiwanger. Using Fucose Analogs as Inhibitors of Notch Signaling. GLYCOBIOLOGY. 2015. 25. 11. 1265-1265
more...
Books (1):
  • Handbook of Glycosyltransferases and Related Genes 2nd ed.
    2013
Lectures and oral presentations  (5):
  • Regulation of Notch signaling by O-glucosylation
    (The 92nd Annual Meeting of the Japanese Biochemical Society 2019)
  • O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking.
    (The 41st Annual Meeting of the Molecular Biology Society of Japan 2018)
  • Significant roles of O-glucose glycans in mammalian Notch trafficking and signaling
    (The annual meeting of the Society for Glycobiology 2018)
  • O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking.
    (Benzon Foundation Symposium #64 2018)
  • Significance of O-glucosylation in the Notch signaling pathway
    (ConBio2017 2017)
Education (2):
  • 1996 - 2001 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • 1992 - 1996 The University of Tokyo Faculty of Pharmaceutical Science
Professional career (3):
  • B.S. (Pharmacology) (The University of Tokyo)
  • M.S. (Pharmacology) (The University of Tokyo)
  • Ph.D. (Pharmacology) (The University of Tokyo)
Work history (7):
  • 2019/10 - 現在 Ochanomizu University
  • 2017/04 - 現在 Nagoya University Associate Professor
  • 2015/07 - 2017/03 The University of Georgia Associate Research Scientist
  • 2008/04 - 2015/06 Stony Brook University Research Assistant Professor
  • 2006/04 - 2008/03 Stony Brook University Research Scientist
Show all
Awards (3):
  • 2018/11 - Daiko Foundation The 33rd international academic exchange research grant
  • 2011 - Gordon Research Conferences (Glycobiology) Achievement award
  • 2006 - Astellas Foundation for Research on Metabolic Disorders The fellowship for research on metabolic disorders
Association Membership(s) (1):
The Society for Glycobiology
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