Takeuchi Hideyuki

タケウチヒデユキ | Takeuchi Hideyuki

Affiliation and department：

Research field (4)： Cell biology , Functional biochemistry , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (13)： Glycoproteomics , Quality control , Folding , EGF repeats , O-Glycans , O-Glucosylation , Mass spectrometry , Glycosyltransferase , Notch signaling , Biochemistry , Glycobiology , がんの生物学 , Cancer Biology

Research theme for competitive and other funds (16)：

2022 - 2025 糖転移酵素群によるNOTCHタンパク質の分泌・分解の仕分け機構の解明
2019 - 2022 Significance of structural diversity of O-glucose glycans in Notch signaling
2019 - 2022 血管内皮におけるNotchシグナル精密制御の基盤となる非典型糖鎖修飾の統合的解析
2019 - 2022 O-グルコース糖鎖修飾による筋衛星細胞における Notch シグナルの制御機構の解明
2019 - 2021 生体内において自由自在に Notch シグナルの強弱を変化させる分子ハンドルの創生

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Papers (76)：

Yohei Tsukamoto, Natsumi Tsukamoto, Wataru Saiki, Yuko Tashima, Jun-Ichi Furukawa, Yasuhiko Kizuka, Yoshiki Narimatsu, Henrik Clausen, Hideyuki Takeuchi, Tetsuya Okajima. Characterization of galactosyltransferase and sialyltransferase genes mediating the elongation of the extracellular O-GlcNAc glycans. Biochemical and biophysical research communications. 2024. 703. 149610-149610
Koki Amano, Yuuki Kurebayashi, Tadanobu Takahashi, Yutaka Narimichi, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Hideyuki Takeuchi. Visualizing intracellular sialidase activity of influenza A virus neuraminidase using a fluorescence imaging probe. Journal of virological methods. 2024. 323. 114838-114838
Rina Hanai, Hiroshi Matsushita, Akira Minami, Yuki Abe, Rika Tachibana, Kazushi Watanabe, Hideyuki Takeuchi, Akihiko Wakatsuki. Effects of 10-Hydroxy-2-decenoic Acid and 10-Hydroxydecanoic Acid in Royal Jelly on Bone Metabolism in Ovariectomized Rats: A Pilot Study. Journal of clinical medicine. 2023. 12. 16
Ailing Zhang, Yohei Tsukamoto, Hideyuki Takeuchi, Kimitoshi Nishiwaki, Yuko Tashima, Tetsuya Okajima. Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation. Analytical Biochemistry. 2022. 656. 114881-114881
Yohei Tsukamoto, Mitsutaka Ogawa, Kentarou Yogi, Yuko Tashima, Hideyuki Takeuchi, Tetsuya Okajima. Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1. Glycobiology. 2022. 32. 7. 616-628

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MISC (47)：

Wataru Saiki, Chenyu Ma, Tetsuya Okajima, Hideyuki Takeuchi. Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions. Biomolecules. 2021. 11. 2. 309-309
田嶌優子, 後藤和佳子, 妹尾勇弥, 塚本庸平, 池田和貴, 小川光貴, 竹内英之, 岡島徹也. Regulation of transport for Delta-like 1 homolog from the ER to the cell surface by O-glycans. 日本糖質学会年会要旨集. 2020. 39th
TAKEUCHI Hideyuki. Notch-Modifying Protein O-Glucosyltransferase 1 (POGLUT1): Specificities, Structures, and Human Disease Implications. Trends in Glycoscience and Glycotechnology. 2019
小川光貴, 与儀賢太朗, 妹尾勇弥, 妹尾勇弥, 池田和貴, 竹内英之, 岡島徹也. 新しい糖鎖構造:フコース含有O-GlcNAc glycanの証明. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
田嶌優子, 後藤和佳子, 妹尾勇弥, 塚本庸平, 池田和貴, 小川光貴, 竹内英之, 岡島徹也. Delta-like1homologのO型糖鎖修飾による細胞膜発現制御機構の解析. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd

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Books (2)：

Handbook of Glycosyltransferases and Related Genes 2nd ed.
2013
糖鎖生物学
共立出版 2000

Lectures and oral presentations (9)：

Regulation of the Notch intercellular signaling pathway by O-glucosylation
(2021)
Abnormalities in Notch O-glucosylation and their relationship to muscle pathology
(2021)
Significance of regulation of Notch signaling by O-glucose glycans
(2021)
Regulation of Notch signaling by O-glucosylation
(The 92nd Annual Meeting of the Japanese Biochemical Society 2019)
O-グルコース糖鎖修飾による衛星細胞における Notch シグナル制御の重要性
(日本筋学会第 5 回学術集会 2019)

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Education (2)：

1996 - 2001 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
1992 - 1996 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (3)：

B.S. (Pharmacology) (The University of Tokyo)
M.S. (Pharmacology) (The University of Tokyo)
Ph.D. (Pharmacology) (The University of Tokyo)

Work history (9)：

2021/04 - 現在 University of Shizuoka School of Pharmaceutical Sciences Professor
2019/10 - 現在 Ochanomizu University Graduate School of Humanities and Sciences
2017/04 - 2021/03 Nagoya University Graduate School of Medicine Associate Professor
2015/07 - 2017/03 The University of Georgia Complex Carbohydrate Research Center Associate Research Scientist
2008/04 - 2015/06 Stony Brook University Dept. of Biochemistry and Cell Biology Research Assistant Professor

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Committee career (9)：

2023/07 - 現在 J Biol Chem Editorial Board Member
2022/04 - 現在 The Pharmaceutical Society of Japan Editor
2021/09 - 現在 The Japanese Biochemical Society Councilor
2021/06 - 現在 The Japanese Biochemical Society Program committee member
2021/04 - 現在 The Japanese Society of Carbohydrate Research Councilor

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Awards (3)：

2018/11 - Daiko Foundation The 33rd international academic exchange research grant
2011 - Gordon Research Conferences (Glycobiology) Achievement award
2006 - Astellas Foundation for Research on Metabolic Disorders The fellowship for research on metabolic disorders

Association Membership(s) (5)：

The Pharmaceutical Society of Japan , The Society for Glycobiology , 日本生化学会 , 日本癌学会 , 基盤的がん免疫研究会

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