Takeuchi Hideyuki

タケウチヒデユキ | Takeuchi Hideyuki

Affiliation and department：

Research field (4)： Cell biology , Functional biochemistry , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (13)： Glycoproteomics , Quality control , Folding , EGF repeats , O-Glycans , O-Glucosylation , Mass spectrometry , Glycosyltransferase , Notch signaling , Biochemistry , Glycobiology , がんの生物学 , Cancer Biology

Research theme for competitive and other funds (16)：

2022 - 2025 糖転移酵素群によるNOTCHタンパク質の分泌・分解の仕分け機構の解明
2019 - 2022 Significance of structural diversity of O-glucose glycans in Notch signaling
2019 - 2022 血管内皮におけるNotchシグナル精密制御の基盤となる非典型糖鎖修飾の統合的解析
2019 - 2022 O-グルコース糖鎖修飾による筋衛星細胞における Notch シグナルの制御機構の解明
2019 - 2021 生体内において自由自在に Notch シグナルの強弱を変化させる分子ハンドルの創生

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Papers (86)：

Saeko Sugiyama, Hiroshi Matsushita, Akira Minami, Hatsune Nakao, Shota Hata, Ayumi Matsumoto, Hideyuki Takeuchi, Akihiko Wakatsuki. Administration of Young Coconut (Cocos nucifera L.) Juice Ameliorates Memory Impairment in a Menopausal Rat Model. Diseases. 2024. 12. 10. 250-250
Shodai Suzuki, Taiki Mashiko, Yohei Tsukamoto, Miyu Oya, Yuki Kotani, Saki Okawara, Takemi Matsumoto, Yuki Mizue, Hideyuki Takeuchi, Tetsuya Okajima, et al. The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants. Journal of Biological Chemistry. 2024
Bunta Tsukamoto, Yuuki Kurebayashi, Tadanobu Takahashi, Yusuke Abe, Ryohei Ota, Yoshiki Wakabayashi, Anju Nishiie, Akira Minami, Takashi Suzuki, Hideyuki Takeuchi. VP1 of human and murine noroviruses recognizes glycolipid sulfatide via the P domain. The Journal of Biochemistry. 2024
Tadanobu Takahashi, Yuuki Kurebayashi, Tadamune Otsubo, Kiyoshi Ikeda, Kobun Konagaya, Shunsuke Suzuki, Mika Yamazaki, Kenya Suzuki, Yutaka Narimichi, Akira Minami, et al. Novel sialidase inhibitors suppress mumps virus replication and infection. Glycobiology. 2024. 34. 11. cwae059
Bat-Erdene Jargalsaikhan, Masanaga Muto, Youngeun Been, Shoma Matsumoto, Eiichi Okamura, Tadanobu Takahashi, Yutaka Narimichi, Yuuki Kurebayashi, Hideyuki Takeuchi, Takashi Shinohara, et al. The Dual-Pseudotyped Lentiviral Vector with VSV-G and Sendai Virus HN Enhances Infection Efficiency through the Synergistic Effect of the Envelope Proteins. Viruses. 2024. 16. 6

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MISC (48)：

籏祥太, 南彰, 井内彩乃, 金沢貴憲, 金沢貴憲, 稲井誠, 紅林佑希, 高橋忠伸, 鈴木隆, 竹内英之. Development of a Parkinson’s disease drug targeting sialidase isozyme NEU2 expressed selectively in the striatum. 日本薬学会年会要旨集(Web). 2024. 144th
Wataru Saiki, Chenyu Ma, Tetsuya Okajima, Hideyuki Takeuchi. Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions. Biomolecules. 2021. 11. 2. 309-309
田嶌優子, 後藤和佳子, 妹尾勇弥, 塚本庸平, 池田和貴, 小川光貴, 竹内英之, 岡島徹也. Regulation of transport for Delta-like 1 homolog from the ER to the cell surface by O-glycans. 日本糖質学会年会要旨集. 2020. 39th
Hideyuki Takeuchi. Notch受容体を修飾するタンパク質O-グルコース転移酵素(POGLUT1):基質特異性、構造、そして、ヒトの病態との関連. Trends in Glycoscience and Glycotechnology. 2019
小川光貴, 与儀賢太朗, 妹尾勇弥, 妹尾勇弥, 池田和貴, 竹内英之, 岡島徹也. 新しい糖鎖構造:フコース含有O-GlcNAc glycanの証明. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd

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Books (2)：

Handbook of Glycosyltransferases and Related Genes 2nd ed.
2013
糖鎖生物学
共立出版 2000

Lectures and oral presentations (9)：

Regulation of the Notch intercellular signaling pathway by O-glucosylation
(2021)
Abnormalities in Notch O-glucosylation and their relationship to muscle pathology
(2021)
Significance of regulation of Notch signaling by O-glucose glycans
(2021)
Regulation of Notch signaling by O-glucosylation
(The 92nd Annual Meeting of the Japanese Biochemical Society 2019)
O-グルコース糖鎖修飾による衛星細胞における Notch シグナル制御の重要性
(日本筋学会第 5 回学術集会 2019)

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Education (2)：

1996 - 2001 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
1992 - 1996 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (3)：

B.S. (Pharmacology) (The University of Tokyo)
M.S. (Pharmacology) (The University of Tokyo)
Ph.D. (Pharmacology) (The University of Tokyo)

Work history (9)：

2021/04 - 現在 University of Shizuoka School of Pharmaceutical Sciences Professor
2019/10 - 現在 Ochanomizu University Graduate School of Humanities and Sciences
2017/04 - 2021/03 Nagoya University Graduate School of Medicine Associate Professor
2015/07 - 2017/03 The University of Georgia Complex Carbohydrate Research Center Associate Research Scientist
2008/04 - 2015/06 Stony Brook University Dept. of Biochemistry and Cell Biology Research Assistant Professor

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Committee career (9)：

2023/07 - 現在 J Biol Chem Editorial Board Member
2022/04 - 現在 The Pharmaceutical Society of Japan Editor
2021/09 - 現在 The Japanese Biochemical Society Councilor
2021/06 - 現在 The Japanese Biochemical Society Program committee member
2021/04 - 現在 The Japanese Society of Carbohydrate Research Councilor

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Awards (3)：

2018/11 - Daiko Foundation The 33rd international academic exchange research grant
2011 - Gordon Research Conferences (Glycobiology) Achievement award
2006 - Astellas Foundation for Research on Metabolic Disorders The fellowship for research on metabolic disorders

Association Membership(s) (5)：

The Pharmaceutical Society of Japan , The Society for Glycobiology , 日本生化学会 , 日本癌学会 , 基盤的がん免疫研究会

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