Matsuzaki Yumi

マツザキユミ | Matsuzaki Yumi

Affiliation and department：
Homepage URL (1)： http://penta-lab.org/

Research field (2)： Cell biology , Physiology

Research keywords (2)：間葉系幹細胞 , Mesenchymal stem cell

Research theme for competitive and other funds (26)：

2024 - 2028 Comprehensive elucidation of the intervertebral disc regeneration mechanism using ultra-high purity stem cells and biomaterials
2023 - 2026 Highly Purified Mesenchymal Stem Cell Therapy for Neuropathy of Congenital Metabolic Disorders Involved on Mitochondria
2021 - 2024 高純度ヒト骨髄間葉系幹細胞と生体活性3次元多孔質足場材料による顎骨再生療法の開発
2020 - 2023 アルギン酸包埋ヒト間葉系幹細胞関節内注射による変形性関節症疾患修飾薬の開発
2019 - 2022 軟骨損傷に対する高純度間葉系幹細胞を用いた新規治療法の開発

2016 - 2019 Maintenance of undifferentiated state and cell fate tracing by visualization of mesenchymal stem cells in vivo

2016 - 2018 Establisment of regenerative techique for jaw bone using MSCs spheroids cultureing with floating condition.

2015 - 2017 Development of therapeutic technology for hypophosphatasia using genetically corrected mesenchymal stem cells

2015 - 2017 間葉系幹細胞の未分化性維持に関わる分子機構

2013 - 2016 Phenotypical and functional characterization of mesenchymal stem cells in the spleen

2012 - 2014 Elucidation of the in vivo migration of mesenchymal stem cells.

2011 - 2012 Transplantation of Porcine Mesenchymal Stem Cell to Regulate SIRS

2010 - 2011 Pathophysiological Roles of Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hepatic Fibrosis

2009 - 2011 Visulization of Wnt/Notch signaling for the maintenance of mesenchymal stem cells

2008 - 2010 Analysis of the onset of ocular chronic graft versus host disease caused by donor-derived fibroblasts and the development of the new therapeutic intervention

2007 - 2009 Activation of intrinsic neural stem cells and induction of neural regeneration using a biologic molecule derived from cells in the brain

2007 - 2008 Olfactory ensheathing cell differentiation for olfactory nervous glia, and establishment of the spinal cord injury treatment model

2007 - 2008 Cell characteristic analysis in cultured human neural stem cells and development of the evaluation system

2007 - 2008 Bone marrow derived cells may play an important role in "gastriccancer stem cell system".

2005 - 2007 Regeneration of female reproductive organs and development of animal model of gynecological disease using adult stem cells.

2005 - 2006 造血および神経系幹細胞におけるNotchシグナル可視化による自己複製機構解明

2005 - 2006 Development of novel treatment strategy for injured brain by using autogenous bioactive factors

2004 - 2006 Visualization of spatiotemporal activation of Notch signaling : live monitoring and significance in neural development and Hematopoiesis

2003 - 2004 シグナル伝達の可視化による幹細胞自己複製の"real time"解析

2002 - 2004 Identification and isolation of adult stem cells in the female reproductive tract and their application to the regenerative medicine.

2002 - 2003 Identification and multi-lineage differentiation of non-hematopoietic stem cells in bone marrow

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Papers (118)：

Satoru Miyagi, Yuko Kato, Ayako Watanabe, Kenichi Miyamoto, Rintaro Yoshikawa, Keita Hagiya, Daisuke Hirano, Yumi Matsuzaki. Generation of a BAC transgenic mouse strain that expresses CreERT and a fluorescent protein under the transcriptional control of the Fzd5 locus. Inflammation and Regeneration. 2022. 42. 1
Jun Namiki, Sayuri Suzuki, Shinsuke Shibata, Yoshiaki Kubota, Naoko Kaneko, Kenji Yoshida, Ryo Yamaguchi, Yumi Matsuzaki, Takeshi Masuda, Yasushi Ishihama, et al. Chitinase-like protein 3: A novel niche factor for mouse neural stem cells. Stem Cell Reports. 2022
Yumi Ohori-Morita, Kunimichi Niibe, Phoonsuk Limraksasin, Praphawi Nattasit, Xinchao Miao, Masahiro Yamada, Yo Mabuchi, Yumi Matsuzaki, Hiroshi Egusa. Novel Mesenchymal Stem Cell Spheroids with Enhanced Stem Cell Characteristics and Bone Regeneration Ability. Stem cells translational medicine. 2022. 11. 4. 434-449
Erina Toda, Yunpeng Bai, Jingjing Sha, Quang Ngoc Dong, Huy Xuan Ngo, Takashi Suyama, Kenichi Miyamoto, Yumi Matsuzaki, Takahiro Kanno. Feasibility of Application of the Newly Developed Nano-Biomaterial, β-TCP/PDLLA, in Maxillofacial Reconstructive Surgery: A Pilot Rat Study. Nanomaterials (Basel, Switzerland). 2021. 11. 2
Seiko Harada, Yo Mabuchi, Jun Kohyama, Daisuke Shimojo, Sadafumi Suzuki, Yoshimi Kawamura, Daisuke Araki, Takashi Suyama, Masunori Kajikawa, Chihiro Akazawa, et al. FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells. Stem cells (Dayton, Ohio). 2020. 39. 3. 318-330

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MISC (242)：

吉川倫太郎, 松崎有未. 【新規の創薬モダリティ細胞医薬細胞を薬として使う、新たな時代の基礎研究と治療法開発】第3章細胞療法の新しい戦略幹細胞ベース間葉系幹細胞による免疫制御. 実験医学. 2020. 38. 17. 2941-2946
宮本憲一, 松崎有未. 間葉系幹細胞の臨床応用の可能性. 血液内科. 2020. 81. 3. 378-383
松崎有未. 間葉系幹細胞治療の可能性と問題点. 島根医学. 2019. 39. 2. 61-66
飯田雄一, 吉川倫太郎, 村田暁彦, 小谷仁司, 松崎有未, 原田守. CCL19発現間葉系細胞の局所投与は抗PD-L1抗体の腫瘍抑制効果を増強する. 日本がん免疫学会総会プログラム・抄録集. 2019. 23回. 102-102
陶山隆史, 宮内裕美, 加藤裕子, 宮本憲一, 松崎有未. ヒト骨髄由来間葉系幹細胞の臨床応用に向けた基礎的検討. Cytometry Research. 2019. 29. Suppl. 74-74

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Books (2)：

Annual Review血液2015
中外医学社 2015 ISBN:9784498125810
膵島の再生医療
診断と治療社 2015 ISBN:9784787821331

Lectures and oral presentations (9)：

Blood specific differentiation potency of purified HSC
(Keystone Symposia 2004)
Visualizing Neural Stem Cells nalysis of Nestin-d4-Venus transgenic mice
(Keystone Symposia 2004)
Existence of side population cells in primary heart cell culture
(第67回日本循環器学会学術集会 2003)
SP cells and multipotent somatic stem cells
(2003)
Hematopoietic specific differentiation potency of pure HSC
(2003)

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Professional career (1)：

MD (Univ. of Tsukuba)

Work history (4)：

2014/04 - 現在 Shimane University Faculty of Medicine, Dept of Life Science professor
2001/09 - 2013/12 Keio University School of Medicine Department of Physiology
1999/04 - 2001/09 Children's Hospital Department of Genetics Director
1998/04 - 1999/03 Children's Hospital Department of Hematology Research Fellow

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