Rchr
J-GLOBAL ID：200901001030783918
Update date: Jan. 16, 2024
Uezono Yasuhito
ウエゾノ ヤスヒト | Uezono Yasuhito
Affiliation and department：
Job title：
Professor
Research field (3)：
Pharmacology
, Neuroscience - general
, Other
Research keywords (3)：
Pain control research
, 神経科学一般
, Neuroscience in General
Research theme for competitive and other funds (83)：
- 2022 - 2025 がん抑制遺伝子PHLDA3の抗がん剤性心機能障害に対する生理作用の解明
- 2022 - 2025 がん患者における術後せん妄予防のプレシジョンメディシンの開発
- 2022 - 2025 ヒトがん悪液質を反映する独自樹立悪液質モデルを用いての悪液質の本態解明、ならびに創薬、診断に有用な「がん悪液質PDXモデル」の確立とその活用
- 2021 - 2024 Development of novel mu-opioid receptor-selective opioids with less adverse effects
- 2021 - 2024 新規デスアシルグレリン受容体を介した化合物やペプチドを用いた抗がん剤心不全の抑制
- 2021 - 2024 オピオイド受容体の細胞内局在と活性変化に基づく最適なオピオイド順次投与法の確立
- 2021 - 2024 がん口腔支持医療における半夏瀉心湯の有用性を明らかにするための基礎及び臨床研究
- 2021 - 2024 がん患者のせん妄発症を予防する抑肝散、および口腔粘膜炎の早期治癒に資する半夏瀉心湯のメタボローム解析によるレスポンダーバイオマーカーの開発ならびに「証」の可視化とその臨床応用
- 2021 - 2024 せん妄ハイリスクがん患者の術後せん妄予防におけるラメルテオンの有効性と安全性に関する多施設共同二重盲検化プラセボ対照ランダム化比較試験
- 2021 - 2024 ヒトiPS細胞由来心筋細胞を用いた抗がん剤の心毒性評価法の開発と国際標準化
- 2020 - 2023 難治性疼痛に対するヒト間葉系幹細胞による鎮痛作用のメカニズム解明とその臨床応用
- 2018 - 2023 リアルタイム可視化アッセイによるオピオイド受容体細胞内動態解析と新規鎮痛法の開拓
- 2018 - 2021 Development of novel, specific heterodimerized opioid agonists with less tolerance and side effects
- 2017 - 2021 Elucidation of risk factors and establishment of new treatment methods for oral complications of cancer patient by salivary metabolome analysis
- 2018 - 2021 外科的がん切除後のデクスメデトミジンによる鎮静に不応な重症せん妄発症を予測するバイオマーカーの開発
- 2017 - 2020 Study on taste disorders and its treatment strategies: A comparative study between Japan and Thailand
- 2016 - 2020 Analysis to reveal the roles of TREK1 on cancer pain and to develop TREK1 agonists as novel analgesics for cancer patients
- 2016 - 2020 Investigation of the mechanism of opioid tolerance formation by visualization real-time analysis and development of new analgesic methods
- 2015 - 2019 Discovery of novel Nav1.7 inhibitors by using bioinformatics
- 2015 - 2019 Influence of cancer progression on central fluid regulation and its mechanism
- 2015 - 2019 Analysis of the role of Gs and Gi protein coupled receptors in the mechanism of action of anesthetics and analgesics
- 2015 - 2018 Research and development of novel mu and delta opioid receptor-specific analgesics
- 2015 - 2018 A pharmacological and clinical study of G protein-coupled antidepressant receptors on astrocytes
- 2013 - 2017 Comparative study on taste sensitivity between Japan and Thailand
- 2013 - 2017 Optimization of opioid therapy based on the diversity of dimerized opioid receptors
- 2013 - 2017 Does Aquaporin channel have an important role in cancer ascites?
- 2012 - 2016 Internalization and recycling profiles of dimeric opioid receptors induced by remifentanil ; Implication for the mechanism of tolerance and hyperalgesia
- 2015 - 2016 漢方薬および生薬有効成分、ならびに食物含有有効成分の安全性・有効性を科学的、客観的に評価する手法の開発
- 2013 - 2015 Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans.
- 2012 - 2015 Management of intolerable pain: development of novel methods for the persistent analgesia by simultaneous activation of heterodimerized Gi-coupled receptors
- 2011 - 2015 The pharmacological analysis of anesthetics in Dorsal root ganglia
- 2011 - 2015 Analysis of the molecular mechanism of the interaction of heterodimerized m-opioid and CB1 receptors
- 2010 - 2013 Development of mechanism-based novel medicaments to pain in advanced cancer
- 2011 - 2013 Investigation of the relationship between opioid kappa receptor subtype and receptor dimerization
- 2011 - 2013 Analysis of central water homeostasis in pathophysiology of cancer cachexia
- 2011 - 2013 The effect of anesthetics on opioid receptor
- 2010 - 2012 Improvement of QOL for cancer patients by a traditional Japanese medicine: Ameliorative effects of cachexia by rikkunshito through ghrelin receptors
- 2010 - 2012 Influence of the chronic pain on skin wound healing
- 2010 - 2012 Analysis of analgesic action of remifentanil through dimerized mu-delta opioid receptors
- 2010 - 2011 Identification of tumor-cell producing novel endogenous analgesic substance
- 2009 - 2011 Overcoming refractory pain : prevention of tolerance of pain by simultaneous activation of G_<i/o>-coupled receptors
- 2009 - 2011 Internalization and recycling profiles ofμ-and dimerizedμ-δopioid receptors induced by remifentanil : implication of acute tolerance of remifentanil.
- 2009 - 2011 Internalization and recycling profiles ofμ-opioid receptors induced by remifentanil ; Implication for the mechanism of tolerance and hyperalgesia
- 2008 - 2010 The molecular mechanism of the prion protein and the homolog which cause the neuro-degenerative/-protective function.
- 2008 - 2010 Internalization profiles of dimerized opioid receptors ; Implication for the mechanism of tolerance
- 2008 - 2009 Gi/o共役型受容体同時活性化による持続的鎮痛療法の開発
- 2007 - 2008 The study on the G protein coupled receptors to find the new analgesics
- 2007 - 2008 Overcome of intolerable pain : improvement of intrathecal drugapplication and its clinical use.
- 2007 - 2008 The analgesic effects of intrathecal morphine and baclofen for refractory pain
- 2006 - 2008 The study of anesthetics and analgesics on opioid receptors
- 2006 - 2007 麻酔薬作用における中枢神経系各部位の果たす役割解析
- 2005 - 2007 The study of the pain mechanisms using rat dorsal root ganglia
- 2005 - 2007 The role of the metabotropic gultamete receptor in the pain mechanism
- 2005 - 2006 Attempt of obstinacy pain easing by spinal cord GABA-B receptor continuation activation.
- 2004 - 2006 麻酔薬、鎮痛薬の痙攣誘発作用におけるセロトニン受容体のはたす役割解明
- 2001 - 2006 G蛋白共役型受容体の多量体化・複合体化とシグナル伝達機構との関連
- 2004 - 2005 Analysis of body GABAB receptor of two hetero amounts that makes creation of improvement of movement in digestive tube medicine target
- 2004 - 2005 麻酔薬の動脈硬化予防作用の臨床応用を目指した研究-麻酔薬の新たなる作用の検討-
- 2003 - 2005 The study of antinociceptive effects of anesthetics and analgesics using dorsal root ganglia cells.
- 2003 - 2004 Identification of factors that modify either the heterodimerization of G protein-coupled receptors or the trafficking of heterodimerized receptors to the cell surface
- 2003 - 2004 Analysis of the neuroendocrine system in PAC1 knock out mice
- 2002 - 2004 The effects of anesthetics and ethanol on cannabinoid receptor function.
- 2001 - 2004 Analysis of singaling mechanisms via heteromultimized or dimerized G protein-coupled receptors.
- 1997 - 2004 G蛋白共役型受容体から成長因子によるシグナル経路へのクロストーク
- 2002 - 2003 G蛋白質共役型受容体発現調節に関わる補助因子をターゲットとした創薬研究の基盤確立
- 2002 - 2003 ニューロステロイドのG蛋白結合受容体及びリガンド結合イオンチャンネルに及ぼす影響
- 2001 - 2002 Regulatory mechanism of aquaporin expression in cerebral microvessels : its pathophysiological significance
- 2001 - 2002 Analysis of the molecular mechanisms of formation and trafficking to the cell surface of the G protein-coupled receptors that require accessory proteins for their expression.
- 1999 - 2002 The role of ATP and purinoceptor in osteoblast-like cell proliferation induced by mechanical stimulation
- 1998 - 2002 Physiological function and gene expression of adremnomedullinfamily : adrenal medullary cells and isolated blood vessels
- 2000 - 2001 Analysis of prostaglandig-mediated regulatory mechanisms in the neuronal and endocrine systems
- 2000 - 2001 Regulation of cell surface expression of voltage-dependent sodium channels by multiple calcium signalings : their mRNA levels and intracellular trafficking
- 1999 - 2000 Identification and analysis of factors that regulate cell surface expression of G-protein coupled receptor
- 1999 - 2000 Modulation of sympathetic nervous system by environmental estrogens : Molecular and pharmacological analysis in adrenal medulla
- 1998 - 1999 Naチャネルの細胞膜発現調節:サブユニットmRNA変動と細胞内輸送・局在化機構
- 1997 - 1998 Electrophysiological and molecular biological analysis on GABA_Breceptors in hypothalamic neuroendocrine cells
- 1997 - 1998 Molecular and pharmacological analysis of the noradrenaline transporter
- 1995 - 1995 副腎髄質細胞の刺激一分泌連関の再構成とその解析〜アフリカツメガエル卵母細胞発現系を用いて〜
- 1995 - 1995 ラット大脳及び血管平滑筋からのアドレノメデュリン受容体のクローニングと機能解析-電気生理学的手法による機能性クローニング法を用いて-
- 1994 - 1994 血圧降下作用を持つペプチドアドレノメデュリンの受容体クローニングとその機能解析-電気生理学を用いた新しい機能性クローニング法によるアプローチ-
- 1991 - 電気生理学的手法を用いての受容体のクローニングと機能的アッセイ
- Cross-talk signaling from G-protein coupled receptors to growth factor-mediated pathway
- Cloning and functional characterization of receptors with electrophysiological methods
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Papers (335)：
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Fumika Karaki, Taro Takamori, Koumei Kawakami, Sae Sakurai, Kyoko Hidaka, Kei Ishii, Tomoya Oki, Noriko Sato, Nao Atsumi, Karin Ashizawa, et al. Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol. Molecules. 2023. 28. 19. 6925-6925
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Naoto Kajitani, Mami Okada-Tsuchioka, Asuka Inoue, Kanako Miyano, Takeshi Masuda, Shuken Boku, Kazuya Iwamoto, Sumio Ohtsuki, Yasuhito Uezono, Junken Aoki, et al. G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023
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Panyawut Sri-iesaranusorn, Ryoichi Sadahiro, Syo Murakami, Saho Wada, Ken Shimizu, Teruhiko Yoshida, Kazunori Aoki, Yasuhito Uezono, Hiromichi Matsuoka, Kazushi Ikeda, et al. Data-driven categorization of postoperative delirium symptoms using unsupervised machine learning. Frontiers in Psychiatry. 2023. 14. 1205605
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Ryoichi Sadahiro, Kotaro Hatta, Takuhiro Yamaguchi, Enokido Masanori, Yoshinobu Matsuda, Asao Ogawa, Yusei Iwata, Akihiro Tokoro, Rika Nakahara, Takatoshi Hirayama, et al. A multi-centre, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of ramelteon for the prevention of postoperative delirium in elderly cancer patients: a study protocol for JORTC-PON2/J-SUPPORT2103/NCCH2103. Japanese Journal of Clinical Oncology. 2023
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Yusuke Karasawa, Kanako Miyano, Masahiro Yamaguchi, Miki Nonaka, Keisuke Yamaguchi, Masako Iseki, Izumi Kawagoe, Yasuhito Uezono. Therapeutic Potential of Orally Administered Rubiscolin-6. International Journal of Molecular Sciences. 2023. 24. 12. 9959-9959
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MISC (292)：
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上園保仁, 宮野加奈子. The Front Line of Development of Novel Opioid Analgesics with Beneficial Profiles Based on the Research of Opioid Receptor-related Signals. 臨床麻酔(真興交易). 2022. 46. 5
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野中美希, 上野晋, 柿木亮, 岸田昭世, 呉林なごみ, 村山尚, 櫻井隆, 上園保仁. 回し車を用いた自発運動負荷によるがん悪液質性心機能障害に対する治療効果の検討. 日本腫瘍循環器学会学術集会抄録集(Web). 2021. 4th
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小松茜, 小松茜, 黒田唯, 黒田唯, 中山大輔, 宮野加奈子, 宮野加奈子, 林田眞和, 上園保仁. 経皮吸収可能なオピオイド製剤開発に向けた新規鎮痛化合物の薬理学的特性評価. 日本麻酔科学会学術集会(Web). 2021. 68th
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黒田唯, 黒田唯, 小松茜, 小松茜, 野中美希, 宮野加奈子, 林田眞和, 上園保仁. 新規エンドセリンA受容体拮抗薬によるオピオイドの鎮痛増強作用のメカニズムの解析:エンドセリンA受容体とμ-オピオイド受容体の二量体化による機能的相互作用の可能性. 日本麻酔科学会学術集会(Web). 2021. 68th
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溝渕有助, 溝渕有助, 溝渕有助, 溝渕有助, 上園瑛子, 上園瑛子, 宮野加奈子, 宮野加奈子, 佐藤哲文, 森松博史, et al. フェンタニルによるオピオイド受容体の脱感作およびケタミン併用による脱感作抑制効果の解析. 日本麻酔科学会学術集会(Web). 2021. 68th
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Books (12)：
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緩和医療薬学(改訂第2版)
南江堂 2023 ISBN:4524234357
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がんサポーティブケアのための漢方活用ガイド (JASCCがん支持医療ガイドシリーズ)
南山堂 2020 ISBN:4525423714
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エース薬理学
南山堂 2020 ISBN:4525140712
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Q&Aでわかる がん疼痛緩和ケア第2版
じほう 2019 ISBN:4840751889
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Functional Dyspepsia: Evidences in Pathophysiology and Treatment
Springer 2018 ISBN:9811310734
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Education (2)：
- 1985 - 1989 University of Occupational and Environmental Health, Japan
- 1979 - 1985 University of Occupational and Environmental Health, Japan School of Medicine
Professional career (1)：
Work history (12)：
- 2020/04 - 現在 The Jikei University School of Medicine Department of Pain Control Research Professor
- 2020/04 - 現在 National Cancer Center Hospital East Supportive and Palliative Care Research Support Office
- 2015/04 - 2020/03 National Cancer Center, Research Institute Division of Cancer Pathophysiology Chief
- 2009/01 - 2015/03 National Cancer Center Research Institute Division of Cancer Pathophysiology Chief
- 2008/04 - 2009/01 Nagasaki University Graduate School of Biomedical Sciences Department of Molecular and Cellular Biology Associate Professor
- 2004/11 - 2008/03 Nagasaki University Graduate School of Biomedical Sciences Department of Molecular and Cellular Biology Associate Professor
- 2000/10 - 2004/10 Nagasaki University School of Medicine Department of Pharmacology Senior Assistant Professor
- 1999/04 - 2000/09 Miyazaki Medical College Senior Assistant Professor
- 1994/05 - 1999/03 University of Occupational and Environmental Health, Japan Senior Assistant Professor
- 1992/07 - 1994/04 University of Occupational and Environmental Health, Japan School of Medicine Assistant Professor
- 1991/01 - 1993/07 California Institute of Technology Division of Biology Postdoctoral Fellow
- 1989/04 - 1992/06 University of Occupational and Environmental Health, Japan
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Committee career (18)：
- 2023/06 - 現在 日本毒性学会 評議員
- 2023/01 - 現在 国際個別化医療学会 理事
- 2021/07 - 現在 日本ペインクリニック学会 特任評議員
- 2020/04 - 現在 日本薬理学会 常置委員
- 2017/10 - 現在 Japanese Association of Supportive Care in Cancer Councilor
- 2016/08 - 現在 日本がんサポーティブケア学会 漢方部会副部長
- 2016/03 - 現在 日本薬理学会 企画教育委員会委員
- 2015/09 - 現在 The Japanese Society of Neuropsychopharmacology Councilor
- 2015/06 - 現在 特定非営利活動法人わたしのがんnet 外部評価委員
- 2014/04 - 現在 特定非営利活動法人JORTC 外部評価委員
- 2012/02 - 現在 特定非営利活動法人キャンサーネットジャパン アドバイザリーボードメンバー
- 2004/10 - 現在 Japan Society of Neurovegetative Research Councilor
- 2002/04 - 現在 The Japanese Pharmacological Society Councilor
- 2019/06 - 2021/05 Japanese Society for Pharmaceutical Palliative Care and Sciences Executive board member
- 2018/03 - 2020/03 日本薬理学会 賞等選考委員会委員
- 2016/03 - 2020/03 The Japanese Pharmacological Society Executive board member
- 2012/05 - 2020/03 日本薬理学会 編集委員会委員
- 2011/06 - 2017/06 Japanese Society for Pharmaceutical Palliative Care and Sciences Auditor-Secretary
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Association Membership(s) (16)：
日本疼痛学会
, 日本がんサポーティブケア学会
, 日本臨床薬理学会
, 日本神経精神薬理学会
, 日本癌学会
, 鎮痛薬・オピオイドペプチド研究会
, 日本緩和医療学会
, 日本緩和医療薬学会
, 日本消化管学会
, 日本生理学会
, 日本自律神経学会
, 米国生理学会
, 日本神経科学会
, 米国神経科学会
, The Japanese Biochemical Society
, The Japanese Pharmacological Society
