Rchr
J-GLOBAL ID：200901001517388593   Update date: Nov. 12, 2024

Fukuda Tsutomu

フクダ ツトム | Fukuda Tsutomu
Homepage URL  (2)： http://www.cms.nagasaki-u.ac.jp/lab/yuuki/ ,  http://www.cms.nagasaki-u.ac.jp/en/
Research field  (4)： Pharmaceuticals - chemistry and drug development ,  Molecular biochemistry ,  Bioorganic chemistry ,  Synthetic organic chemistry
Research keywords  (2)： Medicinal chemistry ,  Synthetic organic chemistry
Research theme for competitive and other funds  (18)：
  • 2024 - 2027 Development of lamellarin-based ER inhibitors that selectively inhibit ER-positive breast cancer cell lines
  • 2023 - 2024 乳がん治療薬を指向したラメラリンをモデルとするエストロゲン受容体阻害剤の創出
  • 2019 - 2022 Development of A- and F-ring-modified lamellarin type inhibitors effective for C797S mutated EGFR
  • 2019 - 2021 抗がん特異性を持つ新規ラメラリン誘導体の分子設計
  • 2019 - 2020 C797S変異EGFRもつ非小細胞肺がんに対して有効なラメラリン系EGFR-TKIの開発
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Papers (73)：
  • Rikiya Horikawa, Gen Onodera, Tsutomu Fukuda, Masanari Kimura. Efficient construction of a quinoline framework from alcohols, nitroarenes, and alkenes promoted by a trimetallic catalyst system. Tetrahedron Chem. 2024. 12. 100108-100108
  • Jun Takouda, Moeka Nakamura, Akane Murasaki, Waka Shimosako, Aoi Hidaka, Shino Honda, Susumu Tanimura, Fumito Ishibashi, Norihiko Kawasaki, Jun Ishihara, et al. Identification of Azalamellarin N as a Pyroptosis Inhibitor. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 28-36
  • Fumito Ishibashi, Shijiao Zha, Taiyo Kondo, Mayu Sakamoto, Mikinori Ueno, Tsutomu Fukuda. Synthesis and structure-activity relationship study of aldose reductase inhibiting marine alkaloid lukianol A and its derivatives. Bioscience, Biotechnology, and Biochemistry. 2023. 87. 2. 148-157
  • Mai Izumida, Osamu Kotani, Hideki Hayashi, Chris Smith, Tsutomu Fukuda, Koushirou Suga, Masatomo Iwao, Fumito Ishibashi, Hironori Sato, Yoshinao Kubo. Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2. Viruses. 2022. 14. 4. 816-816
  • Keita Anoyama, Gen Onodera, Tsutomu Fukuda, Masanari Kimura. C-H Silylation of 2-Arylpyridine Derivatives by Using Iridium Catalyst and Phosphine-Borane Ligand. Advanced Synthesis & Catalysis. 2022. 364. 7. 1223-1227
ｍore...
MISC (3)：
Patents (6)：
  • 第四世代EGFRチロシンキナーゼ阻害剤
  • 第四世代EGFRチロシンキナーゼ阻害剤
  • Fourth-generation EGFR tyrosine kinase inhibitor
  • Fourth-generation EGFR tyrosine kinase inhibitor
  • 抗癌活性化合物
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Lectures and oral presentations  (216)：
  • 親電子的アリル化反応を活用したピロロインドール誘導体の高効率合成法の開発
    (第53回複素環化学討論会 2024)
  • パラジウム触媒によるβ-カルボリン骨格の単工程構築法に関する研究
    (第53回複素環化学討論会 2024)
  • Antitumor mechanism of a novel CDK inhibitor, Azalamellarin 4, which induced apoptosis selectiviely
    (The 83rd Annual Meeting of the Japanese Cancer Association 2024)
  • Copper-Catalyzed Regio- and Stereoselective Synthesis of Azaboroles from Alkynylborates and Aldimines
    (2024)
  • Efficient Construction of Quinoline Framework from Alcohols, Nitroarenes, and Alkenes via Hydrogen Transfer Reaction
    (2024)
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Works (7)：
  • ラメラリンNをリードとするキナーゼ阻害剤に関する研究
    福田 勉 2009 - 現在
  • Development of topoisomerase I inhibitors based on the marine natural product lamellarin D
    FUKUDA Tsutomu 2008 - 現在
  • 海洋天然物ラメラリン類の合成手法の確立
    福田 勉 2002 - 現在
  • インドール類及びピロール類に対する位置選択的リチオ化反応の開発
    福田 勉 1999 - 現在
  • ラメラリンサルフェート類の抗HIV活性発現機序の解明
    2006 - 2011
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Education (3)：
  • 1995 - 1997 Kyushu University Doctor's course, Graduate School of Science Chemistry
  • 1993 - 1995 Kyushu University Master's course, Graduate School of Science Chemistry
  • 1989 - 1993 Kyushu University Faculty of Science Department of Chemistry
Work history (7)：
  • 2021/04 - 現在 Nagasaki University Graduate school of Engineering Associate Professor
  • 2020/06 - 現在 Nagasaki University Environmental Protection Center Associate Professor
  • 2011/04 - 2020/05 Nagasaki University Graduate School of Engineering Assistant Professor
  • 2007/04 - 2011/03 Nagasaki University Graduate School of Science and Technology Assistant Professor
  • 2005/05 - 2007/03 Nagasaki University Graduate School of Science and Technology Research Associate
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Committee career (5)：
  • 2023/03 - 現在 長崎県理科・化学教育懇談会 長崎県理科・化学教育懇談会 幹事
  • 2022/03 - 2023/02 日本化学会九州支部 化学教育協議会 日本化学会九州支部 化学教育協議会 幹事
  • 2022/03 - 2023/02 日本化学会九州支部 日本化学会九州支部 幹事
  • 2022/03 - 2023/02 長崎県理科・化学教育懇談会 長崎県理科・化学教育懇談会 庶務幹事
  • 2021/03 - 2022/02 長崎県理科・化学教育懇談会 長崎県理科・化学教育懇談会 会計幹事
Awards (2)：
  • 2012/11 - Award for Excellent General Presentation in the Medicinal Chemistry Symposium Selectivity control in protein kinase inhibition using axial chirality of lamellarins
  • 2002/10 - Kyushu-Yamaguchi Branch, The Society of Synthetic Organic Chemistry Aword for Young Chemist, Kyushu-Yamaguchi Branch, The Society of Synthetic Organic Chemistry, Japan
Association Membership(s) (9)：
Academic Consociation of Environmental Safety and Waste Management, Japan ,  THE JAPANESE CANCER ASSOCIATION ,  the Society of Iodine Science ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  American Chemical Society ,  Society of Computer Chemistry, Japan ,  The Society of Synthetic Organic Chemistry, Japan ,  The Chemical Society of Japan
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