Rchr
J-GLOBAL ID:200901001658530679   Update date: Oct. 15, 2024

Kohno Takashi

コウノ タカシ | Kohno Takashi
Affiliation and department:
Job title: Chief
Homepage URL  (1): http://www.ncc.go.jp/en/nccri/divisions/genome_biology/genome_biology.html
Research field  (1): Pathobiochemistry
Research keywords  (8): 肺がん ,  がん感受性 ,  遺伝子融合 ,  がん個別化治療 ,  lung cancer ,  cancer susceptibility ,  Gene fusion ,  Precision medicine
Research theme for competitive and other funds  (26):
  • 2022 - 2025 肺肉腫様癌に対するPD-1阻害薬治療の最適化と耐性機序の解明
  • 2021 - 2024 Development study on pathological predictive biomarkers for cancer treatment
  • 2020 - 2024 Identification of novel driver genes by whole genome sequencing of early stage lung tumors
  • 2017 - 2022 Association of immune responses with racial differences of cancer development
  • 2018 - 2020 Prediction of timing of driver mutation and distant metastasis in lung adenocarcinoma
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Papers (421):
  • Mayumi Kobayashi Kato, Erisa Fujii, Maiko Yamaguchi, Daiki Higuchi, Yuka Asami, Kengo Hiranuma, Masaaki Komatsu, Ryuji Hamamoto, Koji Matumoto, Tomoyasu Kato, et al. Excellent concordance of the molecular classification between preoperative biopsy and final hysterectomy in endometrial carcinoma. Gynecologic Oncology. 2024. 190. 139-145
  • Yuko Fujiwara, Ryou-U Takahashi, Motonobu Saito, Michinobu Umakoshi, Yoko Shimada, Kei Koyama, Yasushi Yatabe, Shun-Ichi Watanabe, Souichi Koyota, Yoshihiro Minamiya, et al. Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 36. e2407016121
  • Ken Asada, Syuzo Kaneko, Ken Takasawa, Kouya Shiraishi, Norio Shinkai, Yoko Shimada, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Amina Bolatkan, et al. Multi-omics and clustering analyses reveal the mechanisms underlying unmet needs for patients with lung adenocarcinoma and identify potential therapeutic targets. Molecular cancer. 2024. 23. 1. 182-182
  • 望月 晶史, 本多 隆行, 宮崎 泰成, 河野 隆志. 間質性肺炎がもたらす肺発がんの分子機序 遺伝子変化と腫瘍微小環境の視点から. 呼吸器内科. 2024. 46. 1. 85-89
  • Shiori Nakano, Taiki Yamaji, Akihisa Hidaka, Taichi Shimazu, Kouya Shiraishi, Aya Kuchiba, Masahiro Saito, Fumihito Kunishima, Ryouji Nakaza, Takashi Kohno, et al. Dietary vitamin D intake and risk of colorectal cancer according to vitamin D receptor expression in tumors and their surrounding stroma. Journal of gastroenterology. 2024
more...
MISC (231):
  • 望月晶史, 望月晶史, 白石航也, 本多隆行, 角南久仁子, 宮崎泰成, 吉田幸弘, 渡辺俊一, 谷田部恭, 浜本隆二, et al. Mutagenic contribution of passive smoking to lung adeno-carcinogenesis. 日本呼吸器学会誌(Web). 2024. 13
  • 齋藤 良介, 正古 悠一, 津田 明奈, 黒田 高史, 斎藤 元章, 田部 宏, 高野 浩邦, 山田 恭輔, 吉田 裕, 清川 貴子, et al. ベンチワークから臨床へ繋げる婦人科がん治療に対する新たな展望 プラチナ感受性卵巣明細胞がんの遺伝子学的背景. 日本癌治療学会学術集会抄録集. 2023. 61回. OWS11-2
  • Junya Tabata, Takashi Nakaoku, Kosuke Maruyama, Shigenari Nukaga, Ayako Ui, Takashi Kohno. Identification of novel druggable mutations of RET kinase -Novel activation mode of RET kinase protein-. CANCER SCIENCE. 2022. 113. 684-684
  • Kosuke Maruyama, Takashi Nakaoku, Junya Tabata, Shigenari Nukaga, Takashi Kohno. Development of a drug response model: prediction of RET TKIs sensitivity using MD simulation. CANCER SCIENCE. 2022. 113. 923-923
  • Takashi Nakaoku, Junya Tabata, Kosuke Maruyama, Takashi Kohno. Annotation of variants of unknown significance on RET for precision oncology. CANCER SCIENCE. 2022. 113. 368-368
more...
Patents (1):
  • KIF5B遺伝子とRET遺伝子との融合遺伝子、並びに該融合遺伝子を標的としたがん治療の有効性を判定する方法
Education (4):
  • Kyoto University Faculty of Pharmaceutical Sciences
  • 東京大学大学院
  • Kyoto University
  • Graduate School, University of Tokyo
Professional career (2):
  • Medical Doctor
  • 医学博士 (東京大学)
Work history (7):
  • 2010/11 - 現在 国立がん研究センター研究所 ゲノム生物学研究分野 分野長
  • 2000 - 2010 国立がんセンター研究所 生物学部 室長
  • 2010 - - 国立がん研究センター研究所 ゲノム生物学研究分野 分野長
  • 1995 - 2000 国立がんセンター研究所 生物学部 研究員
  • 1995 - 2000 Researcher, Biology Division,
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Committee career (2):
  • 日本癌学会 評議員
  • 日本癌学会評議員
Awards (3):
  • 2020/06 - 公益財団法人 小林がん学術振興会 小林がん学術賞 本邦のがんゲノム医療の発展に資する治療標的分子・診断手法の実装
  • 2018/09 - International Academy for Advanced Oncology (IAAO) JCA-CHAAO Award
  • 2004 - Japanese Cancer Association (JCA) Incitement Award of the Japanese Cancer Association
Association Membership(s) (5):
日本癌学会 ,  日本分子生物学会 ,  The Molecular Biology Society of Japan ,  The Japanese Cancer Association ,  The Japan Society of Human Genetics
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