Research theme for competitive and other funds (30):
2009 - 2011 Investigation of pathophysiologic mechanisms of acute cardiogenic shock by necrotizing toxins from gas gangrene bacilli.
2009 - 2011 Preclinical study for the therapeutic application of botulinum neurotoxin to intractable brain disorders.
2009 - 2010 ボツリヌス神経毒素の結晶構造解析と受容体結合様式の特殊性の解明
2007 - 2008 Investigation of pathogenic manifestative mechanisms of necrotizing toxins from gas gangrene bacilli in malignant edema and blackleg.
2007 - 2008 Analysis of specific structure of Clostridium botulinum C・D mosaic neurotoxins and the development of their detection methods
2007 - 2008 ボツリヌス神経毒素と新たに発見した受容体構成成分との分子間相互作用の解析
2004 - 2005 Studies on the toxic action of cytolethal toxin from Clostridium septicum.
2004 - 2005 Clarification of the occurrence of avian botulism : the approach with molecular biological studies
2001 - 2002 Exploration of the toxic site by use of genetic diversity on Clostridium botulinum neurotoxin genes.
1999 - 2001 Establishment of a mass production system of human monoclonal anti-toxin antibodies
1999 - 2000 Analysis of receptor recognition site on botulinum neurotoxin molecule and its interaction with the receptor.
1999 - 1999 クロストリジュウムの病原性に関する第3回国際会議
1998 - 1999 Toxicological, Genetic and Physiological analyses of neurotoxigenic Clostridium butyricum from food-borne botulism and environment origins
1998 - 1999 MOLECULAR MECHANISMS OF TRANSMITTER RELEASE
1997 - 1998 Molecular mechanisms of receptor recognition by Clostridium botulinum neurotoxins.
1997 - 1998 Development of human anti-toxin monoclonal antibodies
1994 - 1995 STRUCTURE AND FUNCTION OF RECEPTOR FOR CLOSTRIDIUM BOTULINUM TYPE B NEUROTOXIN
1994 - 1994 ボツリヌス神経毒素による神経伝達物質遊離機構の解析
1993 - 1993 rhoがん遺伝子産物の機能とこれを介する情報伝達経路の研究
1991 - 1991 rhoがん遺伝子産物の機能とこれを介する情報伝達経路の研究
1990 - 1990 乳児ボツリヌス症の発症に及ぼす原因菌の病原因子に関する研究
1987 - 1988 Studies on the active domains of Clostridium botulinum neurotoxin and their functions
1986 - 1987 Studies on the roles of bacterial toxins in food poisoning and its prevention
1985 - 1986 Mechnism of internalization of Clostridium botulinum toxin through the neural membrane
1980 - ボツリヌス菌毒素の作用機構
神経伝達機構の解析
ボツリヌス毒素の医学的利用
Function of neurotransmitter release
Medical use for botulinum toxin
Molecular mechanisms of the action of botulinum toxins.
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Papers (67):
Toshiaki Takeuchi, Tsuyoshi Okuno, Ai Miyashiro, Tomoko Kohda, Ryosuke Miyamoto, Yuishin Izumi, Shunji Kozaki, Ryuji Kaji. Clinical Safety and Tolerability of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Botulinum Neurotoxin Subtype A2, in Comparison with Subtype A1 Toxins. Toxins. 2021. 13. 11
Tomoko Kohda, Kentaro Tsukamoto, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto. Translocation domain of botulinum neurotoxin A subtype 2 potently induces entry into neuronal cells. Microbiology and Immunology. 2020. 64. 7. 502-511
Tomoko Kohda, Keiji Nakamura, Koji Hosomi, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto. Response to "Standardized methods must be used to compare the properties of botulinum toxin serotypes". MICROBIOLOGY AND IMMUNOLOGY. 2017. 61. 12. 560-560
Tomoko Kohda, Keiji Nakamura, Koji Hosomi, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto. Characterization of the functional activity of botulinum neurotoxin subtype B6. MICROBIOLOGY AND IMMUNOLOGY. 2017. 61. 11. 482-489
Yasushi Torii, Nakaba Sugimoto, Tomoko Kohda, Shunji Kozaki, Kazunori Morokuma, Yoshikane Horikawa, Akihiro Ginnaga, Akihiko Yamamoto, Motohide Takahashi. Clinical Study of New Tetravalent (Type A, B, E, and F) Botulinum Toxoid Vaccine Derived from M Toxin in Japan. JAPANESE JOURNAL OF INFECTIOUS DISEASES. 2017. 70. 4. 423-429