2022 - 2025 Development of genome-editing drugs of adenovirus vector expressing eight multiplex guide RNAs using models of HBV replication in humanized mice and of HBV carcinomas
2019 - 2022 Development of genome-editing based therapy of papillomavirus-infected lesions with all-in-one adenovirus vectors expressing super-multiplex guide RNA
2020 - 2021 Development of anti-COVID-19 therapy to suppress severe pneumonia by combination using adenovirus vector with ultra-multi guide RNA expression system and protease inhibitors.
2013 - 2016 Analysis of bone formation activity during pregnancy by in vivo imaging
2011 - 2013 外来性DNAを用いた雌雄ゲノムにおけるインプリント領域制御機構の解析
2010 - 2012 Analysis of difference between female and male genome determined in pronuclear stage embryo.
2008 - 2011 BMP受容体欠損マウスにおける肝細胞の損傷修復機構
2009 - 2010 X染色体不活性化におけるレトロポゾンを介したRNAネットワーク
2006 - 2009 雌性生殖器での精子機能制御の仕組み
2008 - 2009 Analysis of genomic reprogramming in mammals by utilizing inactive X chromosome.
2006 - 2008 Regulatory Mechanism of Sperm Function in Female Reproductive Tract
2006 - 2007 RNAのポリA鎖伸長を介した染色体分配制御ネットワーク
2003 - 2006 雄性配偶子の「なりたち」と「はたらき」の分子基盤
2005 - 2006 初期発生胚におけるmRNA修飾と翻訳制御機構の解明
2004 - 2005 父性由来エピジェネティック制御因子の探索と機能解析
2003 - 2005 Molecular basis of spermatogenesis and fertilization in mammals
2002 - 2003 人工的な胚発生系を利用した精子由来RNAの機能解析
2000 - 2002 Studies on the Regulation of Fertilization and Activation of Development
1999 - 2001 遺伝子改変動物を用いた雌雄の産み分けとその応用
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Papers (48)：
Satoko Kise, Ayano Iijima, Chika Nagao, Tadashi Okada, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Yoshiaki Kanemoto, Shigeaki Kato, Tomoko Nakanishi, et al. Functional analysis of vitamin D receptor (VDR) using adenovirus vector. The Journal of Steroid Biochemistry and Molecular Biology. 2023. 230. 106275-106275
Yuya Kato, Hirotaka Tabata, Kumiko Sato, Mariko Nakamura, Izumu Saito, Tomoko Nakanishi. Adenovirus Vectors Expressing Eight Multiplex Guide RNAs of CRISPR/Cas9 Efficiently Disrupted Diverse Hepatitis B Virus Gene Derived from Heterogeneous Patient. Int. J. Mol. Sci. 2021. 22. 10570
Tomoko Nakanishi, Aya Maekawa, Mariko Suzuki, Hirotaka Tabata, Kumiko Sato, Mai Mori, Izumu Saito. Construction of adenovirus vectors simultaneously expressing four multiplex, double-nicking guide RNAs of CRISPR/Cas9 and in vivo genome editing. Scientific reports. 2021. 11. 1. 3961-3961
Nishimura Hitoshi, Kim Ekyune, Nakanishi Tomoko, Kashiwabara Shin-ichi, Ikawa Masahito, Okabe Masaru, Baba Tadashi. Roles of the testis/sperm-specific ADAM family in sperm-egg interaction(Symposium on the Mechanism of Signal Transduction in Fertilization: its Diversity, Universality and Evolution) :. Zoological science. 2002. 19. 12. 1409-1409
NAKANISHI Tomoko, IKAWA Masahito, YAMADA Shuichi, OKABE Masaru. Green fluorescent protein as a vital marker in the study of fertilization. 1999. 9. 1. 27-33
Development of AdVs for CRISPR/Cas9-based gene editing and its application to PKU mouse model
(2020)
Development of all-in-one type adenovirus vectors simultaneously expressing eight multiplex double-nicking guide RNAs and Cas9-nickase
(2019)
All-in-one adenovirus vectors expressing both highly multiplex double-nicking guide RNAs and Cas9 nickase for genome editing therapy
(The 25th Annual Meeting of Japan Society of Gene and Cell Therapy 2019)
Adenovirus vectors expressing highly-multiplex double-nicking guide RNAs in vivo: high efficiency and very low off-target
(2018)
Development of adenovirus vectors expressing highly multiplex double-nicking guide RNAs for in vivo genome editing aiming clinical application
(2018)
