Rchr
J-GLOBAL ID：200901002347213021   Update date: Mar. 22, 2026

Takahashi Miho

タカハシ ミホ | Takahashi Miho
Affiliation and department：
Doshisha University Faculty of Life and Medical Sciences Department of Medical Life Systems

About Doshisha University Faculty of Life and Medical Sciences Department of Medical Life Systems


Job title： Assistant Professor
Research field  (1)： Clinical pharmacy
Research theme for competitive and other funds  (5)：
  • 2023 - 2026 Molecular mechanism underlying the production of exosome-associated Shiga toxin 2a, which causes severe toxicity in mice
  • 2018 - 2021 Development of a new therapeutic agent that inhibits the production of exosome-associated Shiga toxin 2
  • 2015 - 2018 Development of a novel Shiga toxin inhibitor that targeting of intracellular transport of the toxin
  • 2010 - 2012 Development peptide-based compounds which bind to the specific receptor-binding region of Shiga toxin B subunit
  • 2008 - 2009 An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin.
Papers (33)：
  • Aoi Ikegami, Shuya Ishida, Nozomu Kono, Yuta Okuda, Jumpei Omi, Miho Watanabe-Takahashi, Kiyotaka Nishikawa. Trans-localization of p210 BCR-ABL to the mitochondria is mediated by the interaction of its PH domain with cardiolipin exposed on the outer membrane. Biochemical and Biophysical Research Communications. 2025. 788. 152819-152819
  • Masataka Anzai, Miho Watanabe-Takahashi, Hiroshi Kawabata, Yuri Masuda, Aoi Ikegami, Yuta Okuda, Tsuyoshi Waku, Hiroaki Sakurai, Keizo Nishikawa, Jun-Ichiro Inoue, et al. Clustered peptide regulating the multivalent interaction between RANK and TRAF6 inhibits osteoclastogenesis by fine-tuning signals. Communications biology. 2025. 8. 1. 643-643
  • Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, et al. CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection. mBio. 2024
  • Miho Watanabe-Takahashi, Tetsuya Tanigawa, Takashi Hamabata, Kiyotaka Nishikawa. A tetravalent peptide efficiently inhibits the intestinal toxicity of heat-labile enterotoxin by targeting the receptor-binding region of the B-subunit pentamer. Biochemical and Biophysical Research Communications. 2024. 734. 150769-150769
  • Watanabe-Takahashi M, Kumoi K, Yamamoto H, Shimizu E, Motoyama J, Hamabata T, Nishikawa K. Tailored multivalent peptide targeting the B-subunit pentamer of Cholera toxin inhibits its intestinal toxicity by inducing aberrant transport of the toxin in cells. Biochem. Biophys. Res. Commun. 2024. 716. 149991
ｍore...
MISC (5)：
Patents (10)：
  • P210 PH結合ペプチドおよび慢性骨髄性白血病治療薬
  • Stx1毒性阻害ペプチドおよびStx1に起因する疾患の治療薬
  • Stx2阻害4価ペプチドおよびこのStx2阻害4価ペプチドを含む治療薬
  • LT阻害4価ペプチドおよびETEC感染症治療薬
  • CT阻害4価ペプチドおよびコレラ治療薬
ｍore...
Lectures and oral presentations  (8)：
  • Stx2fのAならびにBサブユニットを 標的とした阻害薬開発
    (第26回腸管出血性大腸菌感染症研究会 2024)
  • 個体強毒性発現に関わるStx2aの 細胞外放出機構におけるGSK3βの関与
    (第26回腸管出血性大腸菌感染症研究会 2024)
  • Shiga toxin 2 (Stx2)の細胞内輸送制御による個体毒性の抑制
    (第25回腸管出血性大腸菌感染症研究会 2023)
  • 受容体結合部位を標的とした新規ペプチド性Subtilase cytotoxin阻害薬の開発
    (第22回腸管出血性大腸菌感染症研究会 2018)
  • 酵素活性部位を標的とした新規ペプチド性Stx阻害薬の開発
    (第22回腸管出血性大腸菌感染症研究会 2018)
ｍore...
Education (2)：
  • 2003 - 2006 Hoshi University
  • 2001 - 2003 Hoshi University
Professional career (2)：
  • 博士(薬学) (星薬科大学)
  • 修士(薬学) (星薬科大学)
Work history (2)：
  • 2007 - 2008 同志社大学工学部環境システム学科特別研究員
  • 2003 - 2007 国立国際医療センター研究所臨床薬理研究部流動研究員
Awards (1)：
  • 2012 - 腸管出血性大腸菌感染症研究会 奨励賞
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