Kohara Kyoko

コハラキョウコ | Kohara Kyoko

Affiliation and department：

Research field (3)： Virology , Molecular biology , Laboratory animal science

Research keywords (6)：実験動物学 , 分子生物学 , ウイルス学 , Laboratory Animal Research , Molecular Biology , Virology

Research theme for competitive and other funds (26)：

2020 - 2023 Basic study for identification of common FMDV, CSFV IRES factors and its application
2015 - 2017 Foot and mouth disease virus specific translation inhibition and application for development of disease resistant livestock
2013 - 2015 ツパイゲノム情報に基づく肝炎ウイルス動物感染系の確立に関する研究
2011 - 2013 Impact of hepatitis C virus infection in B cells on pathogenesis
2006 - 2007 C型肝炎ウイルスによる遺伝子変異蓄積及び細胞不死化機序の解析

2004 - 2005 Establishment and analysis of measles virus-susceptible transgenic mice.

2002 - 2003 Development of the new vaccine and a delivery vector by the recombination Morbilli virus.

2000 - 2003 Analysis of the species specific pathogenicity of morbillivirus by reverse genetics.

2002 - 2002 新組み換え技術を用いたがん治療用麻疹ウイルスベクターの開発

2001 - 2001 肝炎ウイルスの持続感染制御因子および肝炎肝がん発症機序の解析とその制御

2001 - 2001 C型肝炎ウイルスのツパイ感染実験モデル系の開発

1999 - 2001 Development of Immune Induction System by Using The Novel Virus Vectors of Cytokines

2000 - 2000 肝炎ウィルスの感染複製制御因子および肝炎肝がん発症機序の解析とその制御

1999 - 2000 Characterization of HCV replication and pathogenesis in animal model

1998 - 1999 Modification of Cell Growth Regulation by Hepatitis C virus

1996 - 1997 Analysis of persistent infection mechanism of RNA virus

1993 - 1993 C型肝炎ウイルスの蛋白合成開始を支配するRNA領域と開始因子の解析

1991 - 1991 C型肝炎ウイルスの蛋白合成開始におけるウイルスゲノム5'側非翻訳領域の役割

抗ウイルス薬(あるいは抗ウイルス腫瘍薬)の開発

RNAウイルスの病原性発現機構

RNAウイルスと翻訳開始段階の修飾

C型肝炎ウイルスによる細胞増殖制御機構の修飾に関する研究

Anti-viral drug (anti viral tumor) development

Molecular Basis of Pathogenesis in RNA virus infection

Molecular Basis of "Shut-off" mechanism by RNA virus.

Study on Modification of Cell Growth Regulation by Hepatitis C Virus

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Papers (151)：

Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama, Hiroshi Yamazaki. Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11. Drug Metabolism and Disposition. 2024. 52. 9. 1009-1019
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno. Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan. Drug Metabolism and Disposition. 2024. 52. 4. 305-311
Mya Myat Ngwe Tun, Khine Mya Nwe, Jean Claude Balingit, Yuki Takamatsu, Shingo Inoue, Basu Dev Pandey, Takeshi Urano, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kouichi Morita. A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis. Vaccines. 2023. 11. 12. 1857-1857
Lipi Akter, Md Abul Hashem, Tofazzal Md Rakib, Md Haroon Or Rashid, Kazi Anowar Hossain, Rupaly Akhter, Masashi Utsunomiya, Bouchra Kitab, Tatsuro Hifumi, Noriaki Miyoshi, et al. Investigation of koala retrovirus in captive koalas with pneumonia and comparative analysis of subtype distribution. Archives of virology. 2023. 168. 12. 298-298
Kazi Anowar Hossain, Rupaly Akhter, Md Haroon Or Rashid, Lipi Akter, Masashi Utsunomiya, Bouchra Kitab, NgweTun Mm, Takayuki Hishiki, Michinori Kohara, Kouichi Morita, et al. Suppression of dengue virus replication by the French maritime pine extract Pycnogenol®. Virus research. 2023. 199244-199244

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MISC (109)：

小原恭子, MEH Kayesh, KITAB Bouchra, 本田智子, MA Hashem, MYATT M Ngw Etun, HOSSSAIN Kazi, HAROON Rashid, AKHTER Rurally, AKTER Lipi, et al. Development of recombinant dengue vaccinia vaccine which does not induce antibody dependent enhancement. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
Osamu Yoshida, Yusuke Imai, Kana Shiraishi, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara, Takashi Miyazaki, Taizou Kamishita, Mamun Mahtab, Julio C. Aguilar, et al. LONG TERM HBsAg REDUCTION BY A NASAL ADMINISTRATIVE THERAPEUTIC VACCINE CONTAINING HBsAg AND HBCAG MIXED WITH MUCOADHESIVE CVP (CVP-NASVAC) IN PATIENTS WITH CHRONIC HBV INFECTION: THE RESULTS OF 30 MONTHS FOLLOW UP. HEPATOLOGY. 2021. 74. 64A-64A
Osamu Yoshida, Kana Shiraishi, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara, Takashi Miyazaki, Taizou Kamishita, Mamun Mahtab, Julio C. Aguilar, Gerardo E. Guillen, et al. HIGH ANTI-HBS INDUCTION BY RETREATMENT OF A NASAL ADMINISTRATIVE THERAPEUTIC VACCINE CONTAINING HBsAg AND HBCAG MIXED WITH MUCOADHESIVE CVP (CVP-NASVAC) IN CHRONIC HBV INFECTED PATIENTS. HEPATOLOGY. 2021. 74. 507A-508A
吉田理, AKBAR SMF, 今井祐輔, 白石佳奈, 真田孝弘, 小原恭子, 宮崎隆, 上下泰造, 小原道法, 日浅陽一. B型肝炎に対する予防と治療を目的とする経鼻ワクチンの開発. がん予防学術大会プログラム・抄録集. 2021. 2021 (CD-ROM)
齊藤誠, 伊藤靖, 安井文彦, 棟方翼, 山根大典, 小沢真, 山地賢三郎, 山本直樹, 本田智子, 真田崇弘, et al. Targeted macrocycles hamper hemagglutinin adsorption and fusion, and have antiviral effects in murine and macaque models of influenza. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th

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Patents (11)：

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Education (4)：

- 1985 Hokkaido University
- 1985 Hokkaido University Graduate School, Division of Veterinary Medicine
- 1983 Hokkaido University School of Veterinary Medicine
- 1983 Hokkaido University Faculty of Veterinary Medicine

Professional career (2)：

Ph.D. (The University of Tokyo)
Ph.D. (KumamotoUniversity)

Work history (8)：

2011/10 - 現在 Kagoshima University Joint Faculty of Veterinary Medicine Professor
2005/10 - 2011/09 Kumamoto University Professor
2000/09 - 2005/09 Tokyo University Institute of Medical Science Lecturer
1990 - 2000 東京都臨床医学総合研究所・研究員
1990 - 2000 Researcher, The Tokyo Metropolition Institute of Medical Science

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Committee career (1)：

2001 - 2003 日本獣医学会微生物分科会ワークショップ委員(副委員長)

Awards (1)：

2000 - 日本ウイルス学会杉浦賞

Association Membership(s) (4)：

日本癌学会 , 日本分子生物学会 , 日本獣医学会 , 日本ウイルス学会

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