Rchr
J-GLOBAL ID:200901002870202807
Update date: Apr. 19, 2024
SAIGUSA Tadashi
サイグサ タダシ | SAIGUSA Tadashi
Affiliation and department:
Job title:
Professor
Research field (2):
Oral medicine
, Neuroscience - general
Research keywords (6):
Cytokine
, GABA
, Catecholamine
, Basal ganglia
, Central nervous system
, Neuropharmacology
Research theme for competitive and other funds (17):
- 2022 - 2025 慢性腎臓病による認知機能障害に関与する病態修飾因子の検索と治療薬開発
- 2021 - 2024 Studies on the involvement of brain adrenergic receptors in oral dyskinesia
- 2021 - 2024 Orofacial pain mechanism due to infant stress
- 2021 - 2024 Studies on the roles of brain orexin receptors in regulation of chronic pain
- 2020 - 2023 性差による舌痛症発生機構の違いについての基礎研究
- 2018 - 2021 Roles of adrenaline receptor subtypes in regulation of cholinergic activity in nucleus accumbens
- 2017 - 2020 Basic research on a treatment for pain targeting primary afferent A nerve fibers
- 2017 - 2020 Pathological role of endoplasmic reticulum stress in the hippocampal dysfunction seen in chronic kidney disease
- 2019 - 2020 側坐核のアドレナリン受容体サブタイプを介した鎮痛機構の基礎研究
- 2017 - 2020 側坐核のアミン神経活動制御においてGABA受容体サブタイプが果たす役割
- 2014 - 2017 Transition period from peripheral nerve to CNS of the responsible area for abnormal behavior following sciatic nerve injury in rats
- 2012 - 2015 Studies on the mechanisms of noradrenaline and dopamine release in the nucleus accumbens
- 2011 - 2013 Investigation of the epigenetic mechanism of swallowing and respiratory disturbances
- 2007 - 2009 Effects of opioids and supplementary analgesics on the accumbal catecholaminergic activity
- 2002 - 2004 Studies on the mechanisms involved in the development of drug-induced oral dyskinesia
- 2002 - 2003 Reconsideration on the transduction mechanisms coupled to dopamine Di-like receptor
- 1998 - 1999 Central mechanisms involved in the occurrence of oral dyskinesia
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Papers (46):
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Hiroshi Nango, Komugi Tsuruta, Hiroko Miyagishi, Yuri Aono, Tadashi Saigusa, Yasuhiro Kosuge. Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis. Translational Neurodegeneration. 2023. 12. 1
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Hiroki Kawashima, Yuri Aono, Shigeki Shimba, John L.Waddington and Tadashi Saigusa. Adolescence as a critical period for nandrolone-induced muscular strength in relation to abuse liability, alone and in conjunction with morphine, using accumbal dopamine efflux in freely moving rats. Synapse. 2023. in press. 3
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Ryoko Kurisu, Tadashi Saigusa, Yuri Aono, Yoshinori Hayashi, Suzuro Hitomi, Masahiko Shimada, Koichi Iwata, Masamichi Shinoda. Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia. Oral Diseases. 2022. in press
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Hiroki Kawashima, Yuri Aono, Yuriko Watanabe, John L. Waddington and Tadashi Saigusa. In vivo microdialysis reveals that blockade of accumbal orexin OX2 but not OX1 receptors enhances dopamine efflux in the nucleus accumbens of freely moving rats. European Journal of Neuroscience. 2022. 55. 3. 733-745
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Tadashi Saigusa, Yuri Aono and John L. Waddington. Integrative opioid-GABAergic neuronal mechanisms regulating dopamine efflux in the nucleus accumbens of freely moving animals. Pharmacological Reports. 2021. 73. 971-983
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Books (2):
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現代歯科薬理学 第6版
医歯薬出版 2018 ISBN:9784263458112
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ポイントがよくわかるシンプル歯科薬理学
永末書店 2017
Lectures and oral presentations (143):
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OX2 receptors modulate dopamine efflux in nucleus accumbens in a rat chronic inflammatory pain model
(2023)
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P. gingivalisとは異なりE. coli由来のリポ多糖の全身投与はマウスの血中IL-6,TNF-alpha,IL-10を増加させる
(第65回歯科基礎医学会学術大会 2023)
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Stimulation of δ1 and δ2 receptors enhances dopamine efflux in the nucleus accumbens of un-anaesthetized rats through neural mechanisms involving different combination of GABA receptor subtypes
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ラットの脳内のドパミンおよびアセチルコリン放出を指標としたopioid受容体subtypeの機能の分析
(第4回下総薬理学研究会 2023)
-
神経障害性疼痛モデルラットの側坐核のdopamine放出へorexin受容体拮抗薬が及ぼす影響
(第148回日本薬理学会関東部会 2023)
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Education (2):
- - 1994 Nihon University Graduate School, Division of Dental Research 薬理学
- - 1990 Nihon University Faculty of Dentistry 歯学科
Work history (6):
Committee career (9):
- 2020/11 - 現在 日本薬理学会 代議員
- 2018/10 - 現在 日本薬理学会 代議員
- 2015/07 - 現在 日本歯科医学教育学会 評議員
- 2014/10 - 現在 日本歯科基礎医学会 代議員
- 2014/06 - 現在 日本歯科薬物療法学会 評議員
- 2012/10 - 現在 日本神経精神薬理学会 評議員
- 2005/04 - 現在 日本薬理学会 学術評議員
- 2015/07 - 2019/07 日本歯科医学教育学会 編集委員
- 2014/09 - 2017/03 日本薬理学会 代議員
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Awards (1):
- 2012/12 - 佐藤賞(日本大学歯学部佐藤会) 中脳辺縁系ドパミン神経のGABA性制御機構の研究
Association Membership(s) (9):
日本歯科薬物療法学会
, 日本神経科学会
, The International College of Neuropsychopharmacology
, Society for Neuroscience
, 日本歯科基礎医学会
, 日本歯科医学教育学会
, 日本歯科心身医学会
, 日本神経精神薬理学会
, 日本薬理学会
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