2021 - 2024 Translational research using molecular form of B-type natriuretic peptide
2020 - 2023 Elucidation of transcriptional and epigenomic circuit ro reveal molecular mechanisms underlying heart failure and identify novel therapeutic targets
2019 - 2022 Development of novel diagnostic and therapeutic methods for cardiac diseases based on the elucidation of the regulatory mechanism of glycosylation of proBNP
2018 - 2021 Study of sugar chains binding to BNP precursors; 1. Structure analysis, 2. Molecular mechanism, 3. relationship with heart failure condition
2018 - 2021 Potential significance of TRPC3/6 and CNP as novel therapeutic targets of pulmonary arterial hypertension
2017 - 2020 Elucidation of transcriptional and epigenomic regulation for maintaining normal cardiac function
2017 - 2020 Translational science from rare endocrine diseases to lifestyle related diseases
2016 - 2019 Evaluation for regulatory mechanism of glycosylation and secretion of less bioactive proBNP by O-linked glycosylation
2015 - 2018 Elucidation of the molecular mechanism and clinical application of increased plasma level of BNP precursor in patients with heart failure
2014 - 2017 Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism
2013 - 2016 Elucidation of pathophysiological significance of glycosylation in the regulatory mechanism of BNP processing
2011 - 2014 Elucidation of transcriptional and epigenomic regulation in the development of heart failure
2011 - 2013 Translational research of circulation-regulated peptide using B-type natriuretic peptide and adrenomedullin
2010 - 2012 Elucidation of significance of TRPM2 in progression of heart failure
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Papers (81):
Masayuki Shiba, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Yuta Seko, Erika Yamamoto, Yusuke Yoshikawa, et al. Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure. PloS one. 2022. 17. 1. e0263165
Hideaki Inazumi, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takuro Numaga-Tomita, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Miku Oya, Miki Nonaka, et al. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca 2+ Homeostasis. Circulation Research. 2021
Akihisa Kimura, Hiroyuki Takahama, Toshio Nishikimi, Seiji Takashio, Tomohiro Hayashi, Chiaki Nagai-Okatani, Yasuaki Nakagawa, Satoshi Yasuda, Toshihisa Anzai, Naoto Minamino, et al. Molecular ratio of mature B-type natriuretic peptide in acute heart failure: an indicator for ventricular contractile recovery. ESC heart failure. 2021. 8. 6. 5617-5621
Toshio Nishikimi, Yasuaki Nakagawa. Potential pitfalls when interpreting plasma BNP levels in heart failure practice. Journal of cardiology. 2021
Koh Ono, Satoshi Shizuta, Erika Yamamoto, Naritatsu Saito, Neiko Ozasa, Takao Kato, Eri Kato, Takahiro Horie, Junichi Tazaki, Hiroki Shiomi, et al. Overview of the 84th Annual Scientific Meeting of the Japanese Circulation Society - Change Practice!. Circulation journal : official journal of the Japanese Circulation Society. 2021. 85. 3. 323-329