Rchr
J-GLOBAL ID:200901003248162985
Update date: Jan. 27, 2023
Shibanuma Motoko
シバヌマ モトコ | Shibanuma Motoko
Affiliation and department:
Job title:
Professor
Research field (3):
Pharmacology
, Pharmaceuticals - health and biochemistry
, Cell biology
Research keywords (4):
生物系薬学
, 細胞生物学
, Biopharmcology
, Cell Biology
Research theme for competitive and other funds (6):
- 2009 - ミトコンドリア機能変化と細胞悪性化、幹細胞形質発現との関連
- 2008 - Mitochondrial respiratory activity and malignant conversion of cells
- 上皮-間充織細胞転換(epithelial mesenchymal transition)を含む細胞の悪性化形質に特異的なTGFβ1シグナルの解析(TGFβシグナルとしての活性酸素種の役割)
- 細胞接着斑-核両局在性蛋白質HIC-5複合体による細胞増殖の足場依存性制御機構と癌の悪性化(転移)に関する研究(細胞内レドックスとの関わり)
- Analysis on molecular mechanism of epithelial mesenchymal transition induced by reactive oxygen species and TGFβ1 "a role of reactive oxygen species in TGFβ1 signaling"
- Mechanisms underlying anchorage-dependency of cell growth : its regulation by Hic-5, a focal adhesion protein that shuttles between focal adhesions and the nucleus as a ROS effector "a role of reactive oxygen species (ROS) in cell adhesion signain・・・
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Papers (80):
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Tsuyoshi Maruyama, Koji Saito, Masato Higurashi, Fumihiro Ishikawa, Yohko Kohno, Kazunori Mori, Motoko Shibanuma. HMGA2 drives the IGFBP1 / AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA / RNA -less cancer cells. Cancer Science. 2022
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Kazunori Mori, Masato Higurashi, Fumihiro Ishikawa, Motoko Shibanuma. Rac1-mediated sustained β4 integrin level develops reattachment ability of breast cancer cells after anchorage loss. Cancer science. 2021. 112. 8. 3205-3217
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Mirei Mizuno, Kazunori Mori, Keisuke Tsuchiya, Takashi Takaki, Takashi Misawa, Yosuke Demizu, Motoko Shibanuma, Kiyoshi Fukuhara. Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin. ACS omega. 2020. 5. 36. 23164-23174
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Masato Higurashi, Tsuyoshi Maruyama, Yusuke Nogami, Fumihiro Ishikawa, Yukiko Yoshida, Kazunori Mori, Ken-Ichi Fujita, Motoko Shibanuma. High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells. Experimental cell research. 2020. 389. 1. 111889-111889
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松本 奈都美, 久保田 祐太郎, 石田 博雄, 関戸 匡恵, 柴沼 質子, 嶋田 顕, 藤田 健一. カルボキシルエステラーゼ1の遺伝子多型はカペシタビンとその代謝物の体内動態に影響しない. 日本薬学会年会要旨集. 2020. 140年会. 26L-am06S
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MISC (14):
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丸山 剛, 斉藤 光次, 日暮 大渡, 石川 文博, 河野 葉子, 森 一憲, 柴沼 質子. HMGA2/IGFBP1/AKT経路によるP27KIP1分解機構の制御と癌治療標的としての意義(HMGA2 drives IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein in mitochondria-deficient cancer cells). 日本癌学会総会記事. 2022. 81回. P-1197
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福原潔, 森一憲, 沖山佳生, 三澤隆史, 水野美麗, 出水庸介, 柴沼質子, 大野彰子. Rationally Designed Peptide Modulators of Amyloid β Toxicity in Alzheimer’s Disease. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
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水野美麗, 森一憲, 三澤隆史, 高木孝士, 出水庸介, 柴沼質子, 福原潔. アミロイドβを創薬標的としたシリビニン誘導体の開発. メディシナルケミストリーシンポジウム講演要旨集. 2019. 37th
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Mirei Mizuno, Kazunori Mori, Ikuo Nakanishi, Ken-ichiro Matsumoto, Motoko Shibanuma, Kiyoshi Fukuhara. Design and synthesis ofproanthocyanidin derivatives as an inhibitor of amyloid beta aggregation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2018. 256
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MORI KAZUNORI, NOSE KIYOSHI, SHIBANUMA MOTOKO. Involvement of cyclin D1 in anchorage-independent survival. 2007. 26. 1. 53-53
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Books (2):
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Biological roles of H2O2 produced by treatment with TGFb1 in mouse osteoblastic cells. In Frontiers on reactive oxygen species in biology and medicine(jointly worked)
Excerpta Medica 1994
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Involvement of hydrogen peroxide in the actions of TGFb1(jointly worked)
"Oxidateve Stress, Cell Activation and Viral Infection" 1994
Education (4):
- - 1985 Kyoto University
- - 1985 Kyoto University Graduate School, Division of Pharmaceutical Sciences
- - 1983 Kyoto University Faculty of Pharmaceutical Sciences
- - 1983 Kyoto University Faculty of Pharmaceutical Science
Professional career (1):
Work history (8):
- 1992 - 1995 Showa University School of Pharmacy
- 1992 - 1995 Research Associate, Faculty of Pharmacentical
- 1995 - - 昭和大学薬学部 助教授
- 1995 - - Assistant Professor
- 1985 - 1992 The University of Tokyo The Institute of Medical Science
- 1985 - 1992 Research Assistant, Institute of Medical
- Sciens
- Science, Tokyo University
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Awards (2):
- 1995 - 上原研究奨励賞
- 1991 - 日本組織培養学会奨励賞
Association Membership(s) (3):
日本組織培養学会(評議委員)
, 日本分子生物学会
, 日本癌学会(評議委員)
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