Rchr
J-GLOBAL ID：200901003248162985   Update date: Aug. 22, 2024

Shibanuma Motoko

シバヌマ モトコ | Shibanuma Motoko
Affiliation and department：
Showa University School of Pharmacy, Cancer Cell Biology

About Showa University School of Pharmacy, Cancer Cell Biology


Job title： Professor
Research field  (3)： Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Cell biology
Research keywords  (4)： 生物系薬学 ,  細胞生物学 ,  Biopharmcology ,  Cell Biology
Research theme for competitive and other funds  (35)：
  • 2022 - 2025 転移抑制を目指したRac1によるintegrin β4の分解抑制機構の解明
  • 2021 - 2025 Respiratory chain activity as a target of tumor-agnostic therapy in highly glycolytic/low respiratory tumors
  • 2019 - 2022 Impact of mitochondrial complex I activity on cancer cell proliferation: importance of NAD+ levels
  • 2015 - 2018 A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells
  • 2014 - 2017 Significance of mitochondrial DNA mutations in cancer cells: induction of HMGA2 in response to DNA damage
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Papers (137)：
  • 森 一憲, 中川 英嗣, 日暮 大渡, 石川 文博, 柴沼 質子. 脱ユビキチン化酵素OTUB1によるがん遺伝子TAZの安定化と足場非依存性生存能への寄与(A role of TAZ in anoikis resistance promoted by OTUB1 deubiquitinating enzyme in triple-negative breast cancer cells). 日本癌学会総会記事. 2023. 82回. 1854-1854
  • Hidetsugu Nakagawa, Masato Higurashi, Fumihiro Ishikawa, Kazunori Mori, Motoko Shibanuma. An indispensable role of TAZ in anoikis resistance promoted by OTUB1 deubiquitinating enzyme in basal-like triple-negative breast cancer cells. Biochemical and biophysical research communications. 2023. 649. 1-9
  • Tsuyoshi Maruyama, Koji Saito, Masato Higurashi, Fumihiro Ishikawa, Yohko Kohno, Kazunori Mori, Motoko Shibanuma. HMGA2 drives the IGFBP1 / AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA / RNA -less cancer cells. Cancer Science. 2022. 114. 1. 152-163
  • 中川 英嗣, 石川 文博, 森 一憲, 柴沼 質子. 乳癌細胞の足場非依存性生存におけるTAZの役割(Role of TAZ in promoting cell survival upon anchorage loss in breast cancer cells). 日本癌学会総会記事. 2022. 81回. P-1151
  • 丸山 剛, 斉藤 光次, 日暮 大渡, 石川 文博, 河野 葉子, 森 一憲, 柴沼 質子. HMGA2/IGFBP1/AKT経路によるP27KIP1分解機構の制御と癌治療標的としての意義(HMGA2 drives IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein in mitochondria-deficient cancer cells). 日本癌学会総会記事. 2022. 81回. P-1197
ｍore...
MISC (38)：
  • 日暮大渡, 森一憲, 中川英嗣, 石川文博, 柴沼質子. A role of NAD+-SIRT3/6 axes in control of p21Cip1 expression and cancer cell proliferation. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 中川英嗣, 森一憲, 日暮大渡, 石川文博, 柴沼質子. Stabilization of the oncogene TAZ by the deubiquitinating enzyme OTUB1 contributes to anchorage-independent cell survival in breast cancer cells. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 丸山 剛, 斉藤 光次, 日暮 大渡, 石川 文博, 河野 葉子, 森 一憲, 柴沼 質子. HMGA2/IGFBP1/AKT経路によるP27KIP1分解機構の制御と癌治療標的としての意義(HMGA2 drives IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein in mitochondria-deficient cancer cells). 日本癌学会総会記事. 2022. 81回. P-1197
  • 福原潔, 森一憲, 沖山佳生, 三澤隆史, 水野美麗, 出水庸介, 柴沼質子, 大野彰子. Rationally Designed Peptide Modulators of Amyloid β Toxicity in Alzheimer’s Disease. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
  • 水野美麗, 森一憲, 柴沼質子, 福原潔. Functional improvements of silibinin analogues constrained 3D structure. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
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Books (2)：
  • Biological roles of H2O2 produced by treatment with TGFb1 in mouse osteoblastic cells. In Frontiers on reactive oxygen species in biology and medicine(jointly worked)
    Excerpta Medica 1994
  • Involvement of hydrogen peroxide in the actions of TGFb1(jointly worked)
    "Oxidateve Stress, Cell Activation and Viral Infection" 1994
Lectures and oral presentations  (1)：
  • Polycomb-group protein SUZ12 suppresses anoikis by alleviating oxidative stress in cancer cells
    (第143回 日本薬学会年会 2023)
Education (4)：
  • - 1985 Kyoto University
  • - 1985 Kyoto University Graduate School, Division of Pharmaceutical Sciences
  • - 1983 Kyoto University Faculty of Pharmaceutical Sciences
  • - 1983 Kyoto University Faculty of Pharmaceutical Science
Professional career (1)：
  • (BLANK) (The University of Tokyo)
Work history (8)：
  • 1992 - 1995 Showa University School of Pharmacy
  • 1992 - 1995 Research Associate, Faculty of Pharmacentical
  • 1995 - - 昭和大学薬学部 助教授
  • 1995 - - Assistant Professor
  • 1985 - 1992 The University of Tokyo The Institute of Medical Science
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Awards (2)：
  • 1995 - 上原研究奨励賞
  • 1991 - 日本組織培養学会奨励賞
Association Membership(s) (3)：
日本組織培養学会(評議委員) ,  日本分子生物学会 ,  日本癌学会(評議委員)
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