Shibanuma Motoko

シバヌマモトコ | Shibanuma Motoko

Affiliation and department：
Job title： Professor

Research field (3)： Pharmacology , Pharmaceuticals - health and biochemistry , Cell biology

Research keywords (4)：生物系薬学 , 細胞生物学 , Biopharmcology , Cell Biology

Research theme for competitive and other funds (6)：

2009 - ミトコンドリア機能変化と細胞悪性化、幹細胞形質発現との関連
2008 - Mitochondrial respiratory activity and malignant conversion of cells
上皮-間充織細胞転換(epithelial mesenchymal transition)を含む細胞の悪性化形質に特異的なTGFβ1シグナルの解析(TGFβシグナルとしての活性酸素種の役割)
細胞接着斑-核両局在性蛋白質HIC-5複合体による細胞増殖の足場依存性制御機構と癌の悪性化(転移)に関する研究(細胞内レドックスとの関わり)
Analysis on molecular mechanism of epithelial mesenchymal transition induced by reactive oxygen species and TGFβ1 "a role of reactive oxygen species in TGFβ1 signaling"

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Papers (75)：

Masato Higurashi, Tsuyoshi Maruyama, Yusuke Nogami, Fumihiro Ishikawa, Yukiko Yoshida, Kazunori Mori, Ken-Ichi Fujita, Motoko Shibanuma. High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells. Experimental cell research. 2020. 389. 1. 111889-111889
Hiroshi Kuwata, Eriko Nakatani, Satoko Shimbara-Matsubayashi, Fumihiro Ishikawa, Motoko Shibanuma, Yuka Sasaki, Emiko Yoda, Yoshihito Nakatani, Shuntaro Hara. Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019. 1864. 11. 1606-1618
Mirei Mizuno, Kazunori Mori, Takashi Misawa, Takashi Takaki, Yosuke Demizu, Motoko Shibanuma, Kiyoshi Fukuhara. Inhibition of β-amyloid-induced neurotoxicity by planar analogues of procyanidin B3. Bioorganic & medicinal chemistry letters. 2019. 29. 18. 2659-2663
Sekido M, Fujita KI, Kubota Y, Ishida H, Takahashi T, Ohkuma R, Tsunoda T, Ishikawa F, Shibanuma M, Sasaki Y. Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil. Cancer chemotherapy and pharmacology. 2019. 83. 6. 1127-1135
Fujita K, Matsumoto N, Ishida H, Kubota Y, Iwai S, Shibanuma M, Kato Y. Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure. Current drug metabolism. 2019. 20. 5. 361-376

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Books (2)：

Biological roles of H2O2 produced by treatment with TGFb1 in mouse osteoblastic cells. In Frontiers on reactive oxygen species in biology and medicine(jointly worked)
Excerpta Medica 1994
Involvement of hydrogen peroxide in the actions of TGFb1(jointly worked)
"Oxidateve Stress, Cell Activation and Viral Infection" 1994

Education (4)：

- 1985 Kyoto University
- 1985 Kyoto University
- 1983 Kyoto University
- 1983 Kyoto University

Professional career (1)：

(BLANK)

Work history (8)：

1992 - 1995 Showa University School of Pharmacy
1992 - 1995 Research Associate, Faculty of Pharmacentical
1995 - - 昭和大学薬学部助教授
1995 - - Assistant Professor
1985 - 1992 The University of Tokyo The Institute of Medical Science

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Awards (2)：

1995 - 上原研究奨励賞
1991 - 日本組織培養学会奨励賞

Association Membership(s) (3)：

日本組織培養学会(評議委員) , 日本分子生物学会 , 日本癌学会(評議委員)

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