J-GLOBAL ID:200901003248162985   Update date: Nov. 02, 2019


シバヌマ モトコ | SHIBANUMA Motoko
Affiliation and department:
Job title: Professor
Research field  (2): Cell biology ,  Biological pharmacy
Research keywords  (2): Cell Biology ,  Biopharmcology
Research theme for competitive and other funds  (3):
  • Mechanisms underlying anchorage-dependency of cell growth : its regulation by Hic-5, a focal adhesion protein that shuttles between focal adhesions and the nucleus as a ROS effector "a role of reactive oxygen species (ROS) in cell adhesion signain・・・
  • Analysis on molecular mechanism of epithelial mesenchymal transition induced by reactive oxygen species and TGFβ1 "a role of reactive oxygen species in TGFβ1 signaling"
  • 2008 - Mitochondrial respiratory activity and malignant conversion of cells
Papers (14):
  • Mori K, Uchida T, Yoshie T, Mizote Y, Ishikawa F, Katsuyama M, Shibanuma M. A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells. The FEBS journal. 2018. 286. 3. 459-478
  • Kuwata H, Nakatani E, Shimbara-Matsubayashi S, Ishikawa F, Shibanuma M, Sasaki Y, Yoda E, Nakatani Y, Hara S. Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019. 1864. 11. 1606-1618
  • Arai T, Ohno A, Mori K, Kuwata H, Mizuno M, Imai K, Hara S, Shibanuma M, Kurihara M, Miyata N, Nakagawa H, Fukuhara K. Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-β C-terminal peptides. Bioorganic & medicinal chemistry letters. 2016. 26. 22. 5468-5471
  • Mizuno M, Mori K, Misawa T, Takaki T, Demizu Y, Shibanuma M, Fukuhara K. Inhibition of β-amyloid-induced neurotoxicity by planar analogues of procyanidin B3. Bioorganic & medicinal chemistry letters. 2019. 29. 18. 2659-2663
  • Sekido M, Fujita KI, Kubota Y, Ishida H, Takahashi T, Ohkuma R, Tsunoda T, Ishikawa F, Shibanuma M, Sasaki Y. Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil. Cancer chemotherapy and pharmacology. 2019. 83. 6. 1127-1135
MISC (34):
Books (2):
  • Involvement of hydrogen peroxide in the actions of TGFb1(jointly worked)
    "Oxidateve Stress, Cell Activation and Viral Infection" 1994
  • Biological roles of H2O2 produced by treatment with TGFb1 in mouse osteoblastic cells. In Frontiers on reactive oxygen species in biology and medicine(jointly worked)
    Excerpta Medica 1994
Education (2):
  • - 1983 Kyoto University Faculty of Pharmaceutical Science
  • - 1985 Kyoto University Graduate School, Division of Pharmaceutical Sciences
Professional career (1):
  • (BLANK)
Work history (5):
  • 1985 - 1992 Research Assistant, Institute of Medical
  • 1992 - 1995 Research Associate, Faculty of Pharmacentical
  • Science, Tokyo University
  • Sciens
  • 1995 - Assistant Professor
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