2019 - 2022 Study on the amino acid signaling via transporters and receptors for the pharmacologic control of cellular metabolism
2018 - 2020 Study on the effects of amino acid availability on life span and the underlying molecular mechanisms
2015 - 2018 Regulation of cellular metabolism and functions mediated by amino acid transporters and the mechanisms of action of their inhibitors
2015 - 2017 The role of Ubiquitin-Proteasome system in the kidney injury and regeneration
2015 - 2017 Investigation of a novel lipase-like transmembrane protein for the discovery of drugs to regulate the epidermal barrier function
2014 - 2017 Chemo-resistance of xCT expression in NSCLC
2014 - 2015 Identification of a Vesicle specific D-serine transporter in the brain.
2012 - 2015 Identification and the physiological role of a cystine transporter
2012 - 2015 Identification and characterization of a membrane protein TRAP involved in Fanconi syndrome like symptoms.
2012 - 2014 Identification of plasma membrane leucine receptor and elucidation of its link to mTOR signaling pathway
2010 - 2012 Application of F-18-FMT PET for amino acid transporter targetedcancer therapy
2010 - 2011 Signaling mechanisms of a novel-type transmembrane receptor 4F2hc
2009 - 2011 Roles of a novel kidney-specific prostaglandin(PG) transporter in local PG clearance in renal cortex and its pathological relevance
2009 - 2011 New drug development for hyperuricemia targeting novel urate efflux transporter URATv1
2005 - 2010 Transportsome on biomembrane systems: its molecular assembly and physiological function.
2007 - 2009 Identification and functional characterization of plasma membrane amino acid sensors
2005 - 2009 Organic solute transportsomes: their molecular assembly and functional significance
2006 - 2007 Role of System LAmino Acid Transporter in Podocyte Cell Biology
2006 - 2007 Role of a novel prostaglandin transporter OAT-PG in sodium transport regulation mechanism
2005 - 2006 Study on_the protein-protein interaction regulating the function of amino acid transporters
2003 - 2004 Regulatory mechanism of urate transport function by urate transporter binding protein PDZK1
2002 - 2004 Development of novel anti-uricosuric agents based on the genomic strategy.
2001 - 2004 Analysis of Expression of LAT1 in Childhood Leukemia and Effect of Inhibitors on Proliferation Inhibition
2001 - 2004 Genetic Abnormality of Renal Proximal Tubule-Specific Transporters as Causes of Sudden Death Syndrome in South-Eastern Asia
2000 - 2004 Analysis of the vectorial transport of amino acid and drugs in epithelial cells.
2003 - 2003 リバースオンコロジー;がん胎児性LAT1抑制薬による遺伝子変化の網羅的解析
2003 - 2003 腫瘍関連抗原4F2重鎖(CD98)のmTORを介するシグナル機構の解明
2002 - 2003 Identification and functional characterization of all the genes of heterodimeric amino acid transporter family by means of whole genome information
1995 - 1996 Molecular identification of cystine / glutamate exchanger
1995 - 1995 分子キメラを用いたグルタミン酸トランスポータの構造機能相関の解析
1995 - 1995 Roles of glutamate transporters in the nervous system
1988 - 1990 Metabolism of Carcinogenic Heterocyclic Amines in Foods and Establishment of Exposure Level Monitor for these Carcinogens in Humans.
1989 - 1989 環境中の低分子有機化合物の神経機能修飾作用に関する衛生学的研究
Show all
Papers (453)：
Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Kentaro Hisada, Sifan Feng, Yuichiro Kadonaga, Kazuhiro Ooe, Tadashi Watabe, Yoshiyuki Manabe, Atsushi Shimoyama, Masashi Murakami, et al. Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211. International Journal of Molecular Sciences. 2024. 25. 22. 12386-12386
Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Takeru Ota, Eri Wakai, Takashi Sato, Yumi Ohta, Yoshiaki Kikkawa, Hidenori Inohara, et al. Protein profile of mouse endolymph suggests a role in controlling cochlear homeostasis. iScience in press. 2024
Yongchan Lee, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Satoshi Ogasawara, Rangana Warshamanage, Keitaro Yamashita, Garib Murshudov, Osamu Nureki, Takeshi Murata, et al. Structural basis of anticancer drug recognition and amino acid transport by LAT1. Nature Communications. 2024. in press
Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai. LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia. Scientific reports. 2024. 14. 1. 19635-19635
Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kanai. Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells. Journal of Pharmacological Sciences. 2024. 155. 1. 14-20
兼田加珠子, 兼田加珠子, 王谷英達, 王谷英達, 王谷英達, 渡部直史, 渡部直史, 渡部直史, 真鍋良幸, 真鍋良幸, et al. Development of short-lived alpha-emitting nuclear medicine aiming at rare cancer treatment. 日本癌学会学術総会抄録集(Web). 2023. 82nd
裴祥存, 裴祥存, 坂本信一, 趙雪, 齋藤心平, 齋藤心平, 平山友里, 橋本弘史, 佐塚智和, 今村有佑, et al. Investigation of the role of 4F2hc in renal cell carcinoma. 日本泌尿器科学会総会(Web). 2023. 110th
1994 - Award from International Academy for Biomedical and Drug Research in 1994: Special Recognition of Excellence.
Show all
Association Membership(s) (16)：
がん分子標的治療研究会
, 米国細胞生物学会
, 米国神経科学会
, 米国生化学分子生物学会
, 日本腎臓学会
, 日本毒性学会(評議員)
, 日本蛋白質科学会
, 日本細胞生物学会
, 日本分子生物学会
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本薬理学会(評議員)
, THE JAPANESE CANCER ASSOCIATION
, 米国腎臓学会
, THE JAPAN DIABETES SOCIETY
, THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
, 米国薬理学会
