Umemura Masayuki

ウメムラマサユキ | Umemura Masayuki

Affiliation and department：
Job title： Instructor
Other affiliations (1)：

琉球大学大学院医学研究科感染制御医科学専攻分子生物学講座生体防御分野准教授

Homepage URL (1)： http://w3.u-ryukyu.ac.jp/hostdefense/

Research field (2)： Immunology , Bacteriology

Research keywords (2)：感染症学 , Immunology of Host Defence Against Infectious Diseases

Research theme for competitive and other funds (22)：

2023 - 2026 Functional analysis of the signaling adaptor protein during oral candidiasis
2023 - 2026 キーストーン細菌である歯周病菌は肺炎クラミジア感染や動脈硬化を増悪化するか?
2021 - 2024 Analysis of type 3 immune responses against M. tuberculosis infection and application to boost vaccine
2020 - 2023 Analysis of molecular mechanism of mitochondrial damage and immune suppression induced by Mycobacterium tuberculosis
2019 - 2023 Role of IL-35 in pneumonia model mixed infected with Streptococcus pneumoniae and Porphyromonas gingivalis in Ebi3-/- mice.

2018 - 2022 Analysis of multiple defense mechanisms of "type 3 immune response" in mycobacteria infected lungs

2018 - 2021 A role of TAB3 in host defense against mycobacterial infection

2016 - 2020 The role of IL-35 in alveolar bone regeneration using human stem cells

2015 - 2019 Involvement of IL-17 cytokine family in protective immunity to pulmonary mycobacterial infection.

2013 - 2016 Analysis of mechanism of T cell targeting into Mycobacterium tuberculosis-infected lung and development of new lung-targeting vaccine strategy

2011 - 2015 IL-17-mediated regulation of a granuloma formation in pulmonary mycobacterial infection.

2009 - 2011 New role of interleukin-17 in protective immunity against intracellular bacterial infections and its application

2008 - 2010 The elucidation of host defense mechanisms of Mycobacterium tuberculosis infection and the architecture of cytokine-network.

2006 - 2007 肺結核に対する防御免疫誘導におけるInterleukin-17の役割の解明

2006 - 2007 Analysis of induction and activation mechanism of protective CD8 T cells against pulmonary tuberculosis and application for the development of anti-tuberculosis vaccine

2004 - 2005 Analysis of immune system in Mycobacterium tuberculosis-infected lung and vaccine development.

Research on Development of the New Transgenics Vaccine Against Pathogenic Microbes

Analysis of immune Response and Protective Mechanism Against Infections

Fasリガンドによる炎症誘導メカニズムの解析

肺粘膜における感染免疫応答の細胞・分子機構の解明およびその制御法の確立

肺結核におけるInterleukin-17のサイトカイン・ネットワークの構築およびその防御機構の解析

Analysis of immune response and protective mechanism against infections

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Papers (23)：

豊永憲司, 梅村正幸, 松崎吾朗, 原博満, 田中芳彦, 山崎晶. 抗酸菌感染におけるCard9の機能解析(Analysis of Card9 function in pulmonary mycobacterial infection). 日本細菌学雑誌. 2022. 77. 1. 101-101
Tomomi Kurane, Tetsuro Matsunaga, Tomoaki Ida, Kazuko Sawada, Akira Nishimura, Masayuki Fukui, Masayuki Umemura, Masaaki Nakayama, Naoya Ohara, Sohkichi Matsumoto, et al. GRIM-19 is a target of mycobacterial Zn 2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation. The FASEB Journal. 2022. 36. 1
Ei'ichi Iizasa, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Hiroaki Kawaguchi, Masayuki Umemura, Kenji Toyonaga, Hideyasu Kiyohara, Ikuya Yano, Marco Colonna, et al. TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation. Nature communications. 2021. 12. 1. 2299-2299
中田光紀, 高江洲義一, 梅村正幸, 松崎吾朗. 結核菌の病原因子Zmp1を標的とするVHH抗体の開発2. 琉球医学会誌. 2021. 40. 1-4. 68-68
梅村正幸, 山崎雅俊, 田村敏生, 松崎吾朗. マイコバクテリア感染肺への抗原特異的T細胞の動員におけるケモカインレセプターの役割(Role of chemokine receptors in the migration of mycobacterial antigen-specific T cells into the lung). 日本細菌学雑誌. 2020. 75. 1. 141-141

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MISC (71)：

藏根友美, 高江洲義一, 高江洲義一, 松永哲郎, 井田智章, 澤田和子, 梅村正幸, 梅村正幸, 赤池孝章, 松崎吾朗, et al. A molecular mechanism of IL-β inhibition by mycobacterial effector protein. 日本生体防御学会学術総会講演抄録集. 2021. 32nd
高江洲義一, 高江洲義一, 藏根友美, 澤田和子, 西村明, 松永哲郎, 井田智章, 梅村正幸, 梅村正幸, 赤池孝章, et al. A molecular mechanism of IL-1β inhibition by mycobacterial effector protein. 日本生体防御学会学術総会講演抄録集. 2020. 31st
梅村正幸, 梅村正幸, 梅村正幸, 藏根友美, 中山真彰, 大原直也, 高江洲義一, 高江洲義一, 高江洲義一, 松崎吾朗, et al. 病原因子Zmp1欠損マイコバクテリアによるT細胞免疫応答への影響. 日本インターフェロン・サイトカイン学会学術集会抄録集. 2019. 84th
梅村正幸, 梅村正幸, 木村倫和, 岩橋晃平, 藏根友美, 照屋尚子, 中山真彰, 大原直也, 高江洲義一, 高江洲義一, et al. マイコバクテリア病原因子Zmp1の自然免疫およびT細胞免疫応答への影響. 日本熱帯医学会大会プログラム抄録集. 2019. 60th
梅村正幸, 儀間香南子, 高江洲義一, 中江進, 岩倉洋一郎, 松崎吾朗. マイコバクテリア感染肺に誘導されるIL-17A産生細胞の多様性. 日本インターフェロン・サイトカイン学会学術集会抄録集. 2018. 83. 96

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Professional career (1)：

博士(医学) (名古屋大学大学院医学研究科)

Work history (9)：

2012/09 - 現在 University of the Ryukyus Molecular Microbiology Group, Department of Tropical Infectious Diseases, Tropical Biosphere Research Center Associate Professor
2010/04 - 2012/08 University of the Ryukyus Molecular Microbiology Group, Department of Tropical Infectious Diseases, Tropical Biosphere Research Center Assistant Professor
2009/04 - 2010/03 琉球大学分子生命科学研究センター分子感染防御分野助教
2007/04 - 2009/03 University of the Ryukyus Center of Molecular Biosciences
2007/04/01 - - , University of the Ryukyus, Gene Research Center, Research Associate

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Awards (2)：

2008 - 日本生体防御学会日本生体防御学会奨励賞
2007 - 日本生体防御学会日本生体防御学会優秀発表賞

Association Membership(s) (6)：

日本乳酸菌学会 , Japanese Society of Interferon & Cytokine Reseach , THE JAPANESE SOCIETY FOR VIROLOGY , Japanese Society for Host-Defense Research , JAPANESE SOCIETY FOR BACTERIOLOGY , JAPANESE SOCIETY FOR IMMUNOLOGY (JSI)

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