ITAKA Keiji

イタカケイジ | ITAKA Keiji

Affiliation and department：
Other affiliations (1)：

Homepage URL (1)： http://www.tmd.ac.jp/i-mde/www/biofunctions/biofunctions-j.html

Research field (2)： Biomaterials , Biomedical engineering

Research keywords (4)： mRNA therapeutics , バイオマテリアル , 遺伝子治療 , DDS

Research theme for competitive and other funds (24)：

2022 - 2025 Development of a carrier-free transdermal nanobubble mRNA sonoporation transfer vaccine
2020 - 2024 Development of RNA therapies for curing of type 1 diabetes
2020 - 2023 メッセンジャーRNA医薬を用いた神経障害性疼痛の新規治療開発
2019 - 2022 mRNA medicine for treatment of osteoarthritis: An approach for chondrocytes in cartilage tissue
2018 - 2021 Development and Evaluation of New Clinically Applicable Nucleic Acid Drugs for Myocardial Diseases

2016 - 2021 Development of 4-dimensional scaffold system that integrates signaling factors and 3-dimensional structural biomaterials

2017 - 2020 Treatment of spinal cord injury using mRNA medicine

2016 - 2019 mRNA medicine for neuroprotection after cerebral ischemic attack

2016 - 2019 Basic research for regenerative medicine for white matter disorder in central nervous system

2015 - 2018 Development of mRNA medicine for treatment of neural diseases and injury

2016 - 2017 mRNA送達機能構造材料を用いた骨・軟骨再生法の開発に関する基礎的検討

2014 - 2017 治療用核酸頭蓋内送達システムの開発と脳神経系難病治療への展開

2014 - 2017 Development of a new therapeutic strategy for cardiomyopathy by administration of mRNA

2013 - 2017 Development of Polymeric Micelles for Brain-Targeted Delivery of Nucleic Acid Drugs to Treat Intractable Neurological Diseases

2013 - 2016 Induction of IL-17-producing T cells by VEGF-A as starting molecule: Paradigm shift of psoriasis pathogenesis.

2012 - 2015 Development of in vivo mRNA delivery system for treating diseases

2011 - 2013 Gene therapy for achodroplasia using a biocompatible non-viral gene delivery system

2009 - 2011 Development of Novel Therapeutic Angiogenesis Method by Combination of Nanotechnology and siRNA Targeting PHD2

2009 - 2011 A novel approach to treat severe trauma using gene introduction by nanomicelle into skeletal muscle

2008 - 2010 Development of multifunctional polymeric micelles for systemic siRNA delivery

2005 - 2007 Development of multi-functional nanocarrier of siDNA and application for bone and joint diseases

2005 - 2006 Expression Cloning of Joint Regenerative Genes

2004 - 2006 Research and Development for Fabrication of 3D-structured Tissue-engineered Cartilage through Nino-molecular Technologies

生体適合性ナノミセルの医療応用

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Papers (115)：

Xuan Du, Erica Yada, Yuki Terai, Takuya Takahashi, Hideyuki Nakanishi, Hiroki Tanaka, Hidetaka Akita, Keiji Itaka. Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery. Pharmaceutics. 2023. 15. 9. 2291-2291
Maorui Zhang, Yuta Fukushima, Kosuke Nozaki, Hideyuki Nakanishi, Jia Deng, Noriyuki Wakabayashi, Keiji Itaka. Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA. Inflammation and Regeneration. 2023. 43. 1
Kendall Free, Hideyuki Nakanishi, Keiji Itaka. Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection. Pharmaceutics. 2023. 15. 1. 213
Jiarui Cui, Yo Shibata, Keiji Itaka, Jun Zhou, Jiaming Zhang. Unbiased comparison and modularization identify time-related transcriptomic reprogramming in exercised rat cartilage: Integrated data mining and experimental validation. Frontiers in physiology. 2022. 13. 974266-974266
Yasumasa Hashimoto, Hiroshi Kuniishi, Kazuhisa Sakai, Yuta Fukushima, Xuan Du, Kunihiko Yamashiro, Kei Hori, Michihiro Imamura, Mikio Hoshino, Mitsuhiko Yamada, et al. Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy. Progress in neurobiology. 2022. 216. 102288-102288

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MISC (59)：

中西秀之, 位髙啓史. mRNAワクチン・mRNA医薬は何を可能にするのか. ファルマシア. 2022. 58. 5. 415-419
橋本泰昌, 國石洋, 境和久, 福島雄大, DU Xuan, 本橋紀夫, 今村道博, 位高啓史, 一戸紀孝, 関口正幸, et al. 短いジストロフィンDp140は,興奮性シナプス伝達を抑制し,自閉症様行動を引き起こす. 日本筋学会学術集会プログラム・抄録集. 2021. 7th. 110-110
位高啓史, 位高啓史, LIN Chin-Yu, 内田智士, 内田智士, 小牧裕司, 松本征仁, 片岡一則. mRNA医薬による治療用転写因子の生体内送達と組織再生治療. 日本再生医療学会総会(Web). 2020. 19th
蛯原郁弥, 長田和也, 福島雄大, 松本征仁, 位高啓史. Development of muscle-targeted mRNA medicine for treating peripheral nerve injury. 日本バイオマテリアル学会大会予稿集(Web). 2019. 41st
Y. Fukushima, H. Imai, S. Uchida, K. Itaka, H. Nakatomi, K. Kataoka, N. Saito. Transient BDNF introduction therapy against delayed neuronal death in hippocampal CA1 neurons using biocompatible nanomicellar mRNA carrier. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017. 37. 201-201

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Professional career (1)：

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