Rchr

J-GLOBAL ID：200901003607314311 Update date: Jul. 17, 2024

Oritani Kenji

オリタニケンジ | Oritani Kenji

Affiliation and department：

Research field (2)： Hematology and oncology , Immunology

Research keywords (5)：血液内科学 , lymphocyte , Adhesion molecule , Cytokine , Hematology

Research theme for competitive and other funds (60)：

2016 - 2019 The impact of iron overload on immune function
2016 - 2019 Analysis of regulation of signals by STAP adaptor protein in immune system and tumorigenesis
2016 - 2019 Clarification of the roles of anamorsin in the lymphocytes differentiation and proliferation
2016 - 2019 Functional analysis of SATB1, a global transcription regulator, in hematopoietic stem cells
2015 - 2018 Identification of molecular mechanisms activating hematopoietic stem cells by monitoring expression levels of a new stem-cell marker ESAM

2014 - 2017 ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias

2014 - 2017 Variable SATB1 levels regulate hematopoietic stem cell heterogeneity with distinct lineage fate

2014 - 2017 The role of STAP-2 in hematological diseases

2014 - 2017 The role of integrin alpha 8 in the pathogenesis of multiple myeloma

2014 - 2017 The role of SATB1-MS4A3 in the differentiation of hematopoietic stem cells

2014 - 2017 Functional analysis of Anamorsin in iron metabolism in vivo

2013 - 2016 Anti-inflammatory sFRP5 inhibits early B-lymphopoiesis in vivo

2013 - 2016 Analysis of the roles of anti-apoptotic molecule, Anamorsin in immune cells

2013 - 2016 The analysis of bone marrow microenvironment in myelodysplastic syndrome using patient-derived iPS cells

2013 - 2016 Establishment of novel treatment for patients with BCR-ABL-related diseases

2013 - 2016 Analysis of the functions of anti-apoptotic molecule, Anamorsin -the roles in hematopoiesis and cellular iron metabolism-

2013 - 2015 Evaluation of aging by using cell-free nucleic acid

2012 - 2015 Biological characterization of hematopoietic stem cells and leukemic cells by monitoring ESAM expression

2013 - 2014 静止状態の造血幹細胞を活性化させる分子メカニズムの同定

2011 - 2013 Development of novel anti-tumor drugs inhibiting Anamorsin and Picot binding

2011 - 2013 Roles for RUNX1/AML1 in DNA damage-repair pathway

2011 - 2012 Screening of low molecular compounds, which inhibit cell proliferation and survival

2010 - 2012 Analysis of in vivo effects of possible immune regulatory moleculesfor artificial management of immune systems

2010 - 2012 Comprehensive analysis of hematopoietic stem cell-specific genes

2010 - 2012 Analysis of functions of anamorsin, an anti-apoptotic molecule, in hematopoiesis

2010 - 2011 Analysis of leukemogenic transgenic mice generated by tetraploid embryonic complementation method using Tet-off system.

2009 - 2011 Analysis of positive or negative regulatory mechanism for thrombus formation

2009 - 2011 Biological and functional analysis of SFRP1, a novel regulator on early process of lymphopoiesis

2009 - 2011 接着分子による骨髄腫細胞の増殖、分化制御機構の解明

2009 - 2011 Energy metabolism in the growth and differentiation of hematopoietic stem/ progentor cells

2008 - 2010 Roles of leukemogenic oncogenes in the regulation of metabolism, growth, and differentiation of hematopoietic stem cells

2007 - 2008 STIMを中心とした細胞内カルシウム調節機構とサイトカインシグナル

2007 - 2008 Identification and functional analysis of molecules which regulate the earliest events in lymphopoiesis

2007 - 2008 Analysis of regulatory mechanism for α_<IIb>β_3 function by employing newly developed experimental system.

2007 - 2008 Development of a novel interferon with mild adverse effects

2006 - 2007 造血細胞における細胞老化克服遺伝子の単離と機能解析

2006 - 2007 The function of Sir2 in proliferation and aging of hematopoietic cells

2006 - 2007 Synthetic Analysis on the mechanisms of survival and differentiation of hematopoietic cells

2006 - 2007 アディポネクチンの作用機序解明:新しい受容体の同定と結合蛋白の網羅的解析

2006 - 2007 新規Gene-Trap法による多段階の白血病発症に関わる遺伝子単離の試み

2005 - 2006 Establishment of a novel IFN therapy with little side effects

2005 - 2005 Notchの活性化変異による白血病発症機構の解析

2004 - 2004 新規インターフェロンLimitinを中心としたがん治療戦略の確立

2003 - 2004 Difference of biological activities and signals between IFN-ζ/limitin and IFN-α

2003 - 2004 Characterization of regulatory proteins for β3 integrins.

2003 - 2003 骨髄抑制の少ない新規インターフェロン様蛋白Limitinによるがん治療戦略

2002 - 2002 新種のインターフェロンlimitin:新しい癌治療薬としての流動的検討

2001 - 2002 Biological activity of limitin and adiponectin

2001 - 2002 Clinical application of limitin that has anti-tumor and anti-viral activity

2001 - 2001 骨髄抑制の少ない新規インターフェロン様蛋白limitinの癌治療への応用

2001 - 2001 新規造血制御分子limitin,adiponectinの生体内役割の解析

2000 - 2001 Regulatory mechanism of β3 integrin function via signaling molecules

培養ヒトリンパ球の応用

サイトカインシグナル制御に関する研究

造血器腫瘍に対する新規治療戦略

新規アダプター蛋白STAPの機能解析

Clinical application of cultured human lymphocytes

Study on negative regulation of cytokine signaling

Study on a new immunomodurator,adiponectin

Study on a new interferon-like cytokine,limitin

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Papers (124)：

Yuichi Sekine, Kazuna Kikkawa, Sachie Honda, Yuto Sasaki, Shoya Kawahara, Akihiro Mizushima, Sumihito Togi, Masahiro Fujimuro, Kenji Oritani, Tadashi Matsuda. STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation. Scientific Reports. 2024. 14. 1
Kota Kagohashi, Yuto Sasaki, Kiyotaka Ozawa, Takuya Tsuchiya, Shoya Kawahara, Kodai Saitoh, Michiko Ichii, Jun Toda, Yasuyo Harada, Masato Kubo, et al. Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation. The Journal of Immunology. 2024
Yuto Sasaki, Shoya Kawahara, Yuichi Sekine, Jun-Ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda. Potential therapeutic applications of targeting signal-transducing adaptor protein-2 in autoimmune diseases. Exploration of Immunology. 2023. 3. 6. 604-612
Jun-Ichi Kashiwakura, Shoya Kawahara, Iori Inagaki, Kyosuke Inui, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Yuichi Kitai, Ryuta Muromoto, et al. STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN. FEBS letters. 2023. 597. 19. 2433-2445
Yuto Sasaki, Kodai Saitoh, Kota Kagohashi, Toyoyuki Ose, Shoya Kawahara, Yuichi Kitai, Ryuta Muromoto, Yuichi Sekine, Michiko Ichii, Akihiko Yoshimura, et al. STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses. The Journal of Immunology. 2023

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MISC (211)：

田中茜, 大和田千桂子, 三川紫緒, 渡部玲子, 織谷健司, 森直樹, 中世古知昭. COVID-19感染後に発症した血栓性血小板減少性紫斑病(TTP)の1例. 臨床血液. 2023. 64. 4
松田正, 室本竜太, 鍛代悠一, 織谷健司. 【IL-6阻害療法の基礎と臨床】IL-6とそのシグナル伝達系の分子基盤. リウマチ科. 2023. 69. 1. 1-12
Tadashi Matsuda, Kenji Oritani. STAP-2 adaptor protein regulates multiple steps of immune and inflammatory responses. Biological and Pharmaceutical Bulletin. 2021. 44. 7. 895-901
大和田千桂子, 織谷健司, 森直樹, 渡部玲子, 桐戸敬介, 中世古知昭. 造血器悪性腫瘍患者における腸内真菌フローラの解析. 国際医療福祉大学学会誌. 2021. 26
西東秀晃, 一井倫子, 戸田淳, 鍛代悠一, 室本竜太, 柏倉淳一, 斎藤宏大, 横田貴史, 柴山浩彦, 松田正, et al. Signal Transducing Adaptor Protein(STAP)-2はGVHD増悪に関与する. 日本血液学会学術集会抄録(Web). 2020. 82nd

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Works (1)：

遺伝子改変マウスによる宿主免疫調節候補分子の解析:免疫機構の人為的操作を目指して
2010 -

Education (2)：

- 1984 Osaka University Faculty of Medicine Medical School
- 1984 Osaka University Faculty of Medicine

Professional career (1)：

(BLANK)

Work history (1)：

2017/04 - - 国際医療福祉大学医学部教授

Awards (3)：

2000 - 日本白血病基金・清水賞
1999 - アメリカ血液学会Travel Award
1999 - 日本血液学会奨励賞

Association Membership(s) (2)：

日本免疫学会 , 日本血液学会

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