Tanimoto Keiji

タニモトケイジ | Tanimoto Keiji

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://sites.google.com/view/tanimoto-lab

Research field (5)： Genetics , Molecular biology , Animals: biochemistry, physiology, behavioral science , Laboratory animal science , Applied molecular and cellular biology

Research keywords (5)：実験動物 , エピジェネティクス , 遺伝子・染色体工学 , 遺伝子の情報発現と複製 , 遺伝情報発現・制御

Research theme for competitive and other funds (19)：

2020 - 2023 精子核クロマチン高度凝縮に関わるプロタミンは、エピゲノム情報の担い手となるのか?
2019 - 2023 Elucidation of commonalities and specificities in genomic imprinting inheritance by novel mechanisms
2014 - 2020 The role of post-fertilization imprinting methylation mechanism as an epigenomic information repair system
2014 - 2016 マウス・ゲノム刷り込み制御配列のエピゲノムダイナミクス
2008 - 2012 Mechanisms for methylation imprinting establishment afterfertilization

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Papers (92)：

Matsuzaki, Hitomi, Takahashi, Takuya, Kuramochi, Daichi, Hirakawa, Katsuhiko, Tanimoto, Keiji. Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice. NUCLEIC ACIDS RESEARCH. 2023. 51. 14. 7236-7253
Matsuzaki, Hitomi, Sugihara, Shokichi, Tanimoto, Keiji. The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period. Epigenetics & Chromatin. 2023. 16. 1. 7
Matsuzaki, Hitomi, Miyajima, Yu, Fukamizu, Akiyoshi, Tanimoto, Keiji. Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms. Communications biology. 2021. 4. 1. 1410
Hirakawa, Katsuhiko, Matsuzaki, Hitomi, Tanimoto, Keiji. Transient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation period. Human molecular genetics. 2021. 29. 22. 3646-3661
Hitomi Matsuzaki, Daichi Kuramochi, Eiichi Okamura, Katsuhiko Hirakawa, Aki Ushiki, Keiji Tanimoto. Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus. Epigenetics & chromatin. 2020. 13. 1. 2-2

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MISC (8)：

Transcriptional regulation of RAAS genes : in vivo analysis by artificial chromosome transgenic mouse. 2012. 70. 9. 1466-1470
谷本啓司. βグロビン遺伝子座制御における"構造と機能" (特集細胞分化を制御する遺伝情報デコードシステム--転写因子・クロマチン制御・non-coding RNA). 細胞工学. 2006. 25. 1. 17-22
加藤秀樹, 石田純治, 斉藤知子, 松岡俊樹, 谷本啓司, 横尾隆, 藤田敏郎, 南学正臣, 深水昭吉. AngiotensinIIはAngII type1a受容体を介してin vivoにおいて赤血球産生を増加させる. 日本腎臓学会誌. 2005. 47. 3. 258-258
T Hashimoto, M Kihara, K Sato-Yokoyama, K Matsushita, Y Koide, Y Inokuchi, T Sugaya, K Tanimoto, K Tamura, N Hirawa, et al. Expression of cyclooxygenase-2 in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice. HYPERTENSION. 2004. 44. 4. 526-526
K Tanimoto, A Fukamizu, G Felsenfeld, JD Engel. Human b-globin HS5 carries an insulator activity in vivo. BLOOD CELLS MOLECULES AND DISEASES. 2003. 31. 1. 166-166

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Books (10)：

Principles of Biochemistry (7th edition)
Hirokawa Publishing Co. 2019 ISBN:9784567244091
日本臨牀
日本臨牀社 2012
遺伝情報の発現制御 (Gene Control) 転写機構からエピジェネティクスまで
メディカル・サイエンス・インターナショナル 2012
「βグロビン遺伝子座制御における“構造と機能”」
細胞工学(特集)・秀潤社 2006
「βグロビン遺伝子の発現制御機構 ~2次元から3次元へ~」
化学と生物(今日の話題) 2005

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Lectures and oral presentations (58)：

Search for cis regulatory sequences and trans factor candidates involved in post-fertilization imprinted methylation of mouse H19-ICR
(第45回日本分子生物学会年会)
In vivo test for the involvement of a candidate trans factor in post-fertilization imprinted methylation of the H19-ICR
(第45回日本分子生物学会年会)
Post-fertilization allele-specific DNA methylation of the H19-ICR as a maintenance mechanism of genomic imprinting at the Igf2/H19 locus
(第45回日本分子生物学会年会)
トランスジェニックマウスにおけるDlk1-Dio3遺伝子領域IG-DMRの刷り込みメチル化の検証
(第95回日本生化学会大会)
トランスジェニックマウスにおけるラットH19-ICRのDMR形成能の検討
(第94回日本生化学会大会 2021)

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Education (2)：

1989 - 1994 University of Tsukuba Graduate School, Division of Agriculture
1985 - 1989 University of Tsukuba Second Cluster of College

Professional career (1)：

博士(農学) (筑波大学)

Work history (12)：

2012/01 - 現在 University of Tsukuba Faculty of Life and Environmental Sciences Professor
2017/04 - 2020/03 日本学術振興会学術研究センター専門研究員(農学・環境学)
2007/04 - 2012/01 筑波大学大学院生命環境科学研究科准教授
2004/04 - 2007/03 University of Tsukuba Graduate School of Life and Environmental Sciences Associate professor
2003/04 - 2004/03 University of Tsukuba Graduate School of Life and Environmental Sciences, University of Tsukuba Associate professor

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Committee career (1)：

2017/04 - 2024/03 日本生化学会評議員

Awards (1)：

1996 - つくば賞

Association Membership(s) (5)：

JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , The Japanese Society for Epigenetics , The Molecular Biology Society of Japan , THE JAPANESE BIOCHEMICAL SOCIETY , American Society for Microbiology

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