Takashima Seiji

タカシマセイジ | Takashima Seiji

Affiliation and department：
Job title： Professor
Other affiliations (6)：

Osaka University Graduate School of Frontier Biosciences Department of Frontier Biosciences Professor
Osaka University Faculty of Medicine, Medical School Others
Osaka University Graduate School of Frontier Biosciences, Department of Frontier Biosciences, Graduate School of Frontier Biosciences Department of Frontier Biosciences
Osaka University Faculty of Medicine, Medical School, Faculty of Medicine, Medical School
Osaka University Graduate School of Frontier Biosciences, Department of Frontier Biosciences, Graduate School of Frontier Biosciences Department of Frontier Biosciences

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Homepage URL (1)： http://medbio.sakura.ne.jp/

Research field (2)： Cardiology , Medical biochemistry

Research keywords (6)：創薬 , 生化学 , 循環器内科 , Pathophysiology , Biochemistry , Cardiovascular Medicine

Research theme for competitive and other funds (27)：

2024 - 2027 Identification of therapeutic targets for heart failure and development of intervention methods related to the control mechanism of cardiac pump function
2022 - 2025 全ゲノム解析基盤による機能・情報統合解析と新規心筋症遺伝子の同定および機序解明
2021 - 2024 酸化的リン酸化酵素群の分子構造機構の解明と創薬展開に向けた基盤研究
2018 - 2021 Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fraction
2016 - 2019 Therapeutic Application of Genome Editing for Advanced Heart Failure

2016 - 2018 Deciphering the factors associated with selective demethylation of tissue-specific gene promoter

2015 - 2018 Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development

2015 - 2016 エネルギー代謝と細胞運動の相関解析による新しい循環器病治療薬の開発

2014 - 2016 Identification and purification of cardiac fibroblast-specific FGF23 receptor

2014 - 2015 Development of simple and noninvasive method to assess the severity of heart failure

2012 - 2015 Cardiac Myosin Light Chain Kinase Mutation as a Cause of Cardiomyopathies

2011 - 2015 Establishment of a basis to study vertebrate phoneme based on transposon-mediated genetic methods

2012 - 2014 Development of novel drugs for heart failure treatment based on modulating kinase activity of cardiac-MLCK

2010 - 2012 The elucidation of mechanisms for myseterin and its susceptibility variant and development of prevention program for moyamoya disease.

2010 - 2012 Identification and functional analysis of the factors that interact with cardiac protective factor HB-EGF

2007 - 2012 非分裂細胞である心筋細胞の代謝維持機構の解明を行うことによる循環器疾患の新規治療戦略の構築

2009 - 2011 Role of splicing variants in heart failure

2008 - 2010 Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease

2005 - 2010 高分離能カラムの初期利用による生理活性物質検索法の開発

2008 - 2008 新しい概念(エピジェネティクス)を応用した難治性心不全発症分子メカニズムの解明

2007 - 2008 Pathophysiological Role of ER-Ubiquitin/Proteasome System in Cardiovascular Remodeling

2007 - 2008 Translational research of adenosine aiming for diagnosis and treatment of heart failure

2005 - 2006 The role of ER stress and ubiquitin-proteasome system in the development of heart failrue

2005 - 2006 New therapeutic approach for heart failure using HB-EGF mediated signal transduction

2004 - 2005 Experimental and clinical evaluation of cardioprotective effects by adenosine and nitric oxide

2000 - 2001 Acquirement of the Ischemic Cardioprotection and ecto-5'-nucleotidase : Investigation of the Receptor Activation and Subsequent Signal Transduction

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Papers (227)：

Shunsuke Nishimura, Hidetaka Kioka, Shan Ding, Hideyuki Hakui, Haruki Shinomiya, Kazuya Tanabe, Tatsuro Hitsumoto, Ken Matsuoka, Hisakazu Kato, Osamu Tsukamoto, et al. HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response. EMBO reports. 2025
Yusuke Katsuma, Isao Matsui, Ayumi Matsumoto, Hiroki Okushima, Atsuhiro Imai, Yusuke Sakaguchi, Takeshi Yamamoto, Masayuki Mizui, Shohei Uchinomiya, Hisakazu Kato, et al. Endogenous activation of peroxisome proliferator-activated receptor alpha in proximal tubule cells in counteracting phosphate toxicity. American journal of physiology. Renal physiology. 2024
Shinji Tokuyama, Hisakazu Kato, Hidekazu Takahashi, Kyoko Ueda, Asami Arita, Ryuta Ueda, Hiroto Seto, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, et al. BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer. Carcinogenesis. 2024
Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Relative B-Type Natriuretic Peptide Deficiency May Exist in Diastolic Dysfunction in Subclinical Population. Circulation Reports. 2024. 6. 5. 151-160
Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals. JACC: Asia. 2024

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MISC (322)：

井上聖, 松岡研, JO Hyejin, 塚本蔵, 高島成二, 高島成二. Transcriptional regulation of the natriuretic peptide gene during fetal life and heart failure. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
JO Hyejin, 松岡研, 井上聖, 塚本蔵, 塚本蔵, 塚本蔵, 高島成二, 高島成二. Transcription environment imaging of newly identified cardiac-specific enhancer for regulating transcription of natriuretic peptide genes (Nppa, Nppb). 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
JO Hyejin, 松岡研, 井上聖, 塚本蔵, 塚本蔵, 高島成二, 高島成二. Identification of potential enhancers and transcription factors that regulate the expression of Nppa and Nppb genes. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
井上聖, 松岡研, JO Hyejin, 塚本蔵, 塚本蔵, 高島成二, 高島成二. Molecular mechanism of the heart failure-responsive enhancer cluster that regulates the dramatic induction of the natriuretic peptide gene transcription. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
高橋佑典, 齋藤茂芳, 木岡秀隆, 荒木力太, 高島成二, 坂田泰史, 吉岡芳親. 11.7T-MRI装置を用いたマウス下肢骨格筋CrCESTイメージングの確立. 日本放射線技術学会雑誌. 2019. 75. 9. 1050-1050

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Works (5)：

臓器特性を利用した心血管疾患治療標的の探索と臨床応用
2011 -
臓器特性を利用した心血管疾患治療標的の探索と臨床応用
2010 -
心筋細胞の非分裂性を規定する因子の同定・機能解析と治療への応用
2010 -
重症特発性心筋症患者の生体資料の収集および新規予後規定因子の検索・解析
2009 -
心筋細胞の非分裂性を規定する因子の同定・機能解析と治療への応用に向けた基盤研究
2009 -

Professional career (1)：

医学博士 (大阪大学)

Work history (10)：

2013/07 - 現在 Osaka Univ. Graduate School of Medicine, Frontier Biosciences Professor
2008/04 - 2013/06 Osaka Univ. Post Graduate School of Medicine Associate Professor
2004/04 - 2008/03 Osaka Univ. Health Center Assistant Professor
2003/12 - 2004/03 Osaka Univ. Health and Physical Dept. Assistant Professor
2001/12 - 2003/12 Osaka Univ. Graduate Shcool of Medicine Department of Cardiovascular Medicine Lecturer

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Awards (1)：

2008 - 日本医師会医学研究奨励賞

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