Rchr
J-GLOBAL ID:200901005100638096
Update date: Apr. 06, 2024
Nishiyama Makoto
ニシヤマ マコト | Nishiyama Makoto
Affiliation and department:
Job title:
Professor
Homepage URL (2):
http://park.itc.u-tokyo.ac.jp/cbt/
,
http://park.itc.u-tokyo.ac.jp/cbt/en/
Research field (2):
Applied biochemistry
, Applied microbiology
Research keywords (2):
応用微生物学・応用生物化学
, Applied Microbiology and Applied Biochemistry
Research theme for competitive and other funds (29):
- 2022 - 2025 Studies on mining of novel enzymes functioning in secondary metabolite biosynthesis in Streptomyces and their molecular mechanism.
- 2010 - 2020 Studies on enzymes creating natural product diversity
- 2017 - 2018 Elucidation of structures and functions of metabolic enzymes of lysine and related compounds and their molecular evolution
- 2017 - アミノ基キャリアタンパク質を介する生合成機構の解明と二次代謝産物構造多様性の拡張
- 2014 - 2016 Metabolic regulation via protein acylation in Thermus thermophilus
- 2012 - 2016 アミノ基修飾型キャリアタンパク質を介した物質変換機構の解明と応用展開
- 2012 - 2012 リジン生合成および関連一次代謝系酵素群の機能および分子進化の解析
- 2009 - 2011 リジン生合成およびその制御機構の解明に向けた構造生物学的研究
- 2000 - 2010 Structure and function of transcription factors
- 1999 - 2010 Regulation and evolution of amino acid biosynthesis
- 2004 - 2006 Structure-function relationship of novel lysine biosynthetic enzymes and analysis of molecular evolution of the pathway
- 2001 - 2002 Analysis of novel lysine biosynthesis in Thermus and its regulation
- 2000 - 2002 Studies on signal transduction pathways of jasmonic acid in suspension-cultured rice cells
- 1999 - 2001 Bioremediation of xenobiotic compounds including dioxins
- 1999 - 2000 Analysis of mechanisms of regulation of aspartate kinase and lysine biosyntheseis in Thermus thermophilus
- 1997 - 1999 Analysis of structure-function relationships on smooth muscle myosin using NMR and X-ray crystallography.
- 1997 - 1998 Studies on electron-transferring mechanism in an nitrite-reducing system containing Cu-proteins
- 1997 - 1997 耐熱性リンゴ酸脱水素酵素のドメインの折れたたみ機構に関する研究
- 1996 - 1996 精密な立体構造に基づく2つの銅蛋白質の相互作用様式の解析
- 1996 - 1996 ドメインに分断されたリンゴ酸脱水素酵素を用いた折れたたみ機構に関する研究
- 1995 - 1995 蛋白工学的手法による亜硝酸還元系を構成する銅蛋白間の相互作用様式の解析
- 1995 - 1995 耐熱性リンゴ酸脱水素酵素の安定性及び折れたたみ機構に関する研究
- 1994 - 1995 Improvement of milk-clotting enzyme, Mucor rennin, by protein engineering and 「genetic engineering.
- 1994 - 1995 Regulation of secondary metabolism and cell differentiation by A-factor and protein phosphorylation in Streptomyces.
- 1994 - 1994 銅蛋白間の電子伝達機構に関する蛋白工学的研究
- 1993 - 1993 蛋白工学を用いた銅蛋白間の電子伝達機構の解析
- 1992 - 1993 Regulation of secondary metabolism and cellular differentiation by A-factor and signal transduction systems in Streptomyces
- 1990 - 1991 ウシキモシンおよびムコ-ルレンニンの蛋白工学的研究
- 1989 - 1990 放線菌の化学調節物質Aーファクタ-をめぐる調節ネットワ-クに関する研究
Show all
Papers (240):
-
Genki Hibi, Taro Shiraishi, Tatsuki Umemura, Kenji Nemoto, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama. Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin. Nature Communications. 2023. 14. 1
-
Ryuhei Nagata, Makoto Nishiyama, Tomohisa Kuzuyama. Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase. Biochemistry. 2023
-
Toshihiko Katoh, Chihaya Yamada, Michael D Wallace, Ayako Yoshida, Aina Gotoh, Moe Arai, Takako Maeshibu, Toma Kashima, Arno Hagenbeek, Miriam N Ojima, et al. A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem. Nature chemical biology. 2023
-
Sumire Kurosawa, Hironori Okamura, Ayako Yoshida, Takeo Tomita, Yusuke Sone, Fumihito Hasebe, Tetsuro Shinada, Hirosato Takikawa, Saori Kosono, Makoto Nishiyama. Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis. ACS Chemical Biology. 2023
-
Yutaro Morita, Ayako Yoshida, Siyan Ye, Takeo Tomita, Minoru Yoshida, Saori Kosono, Makoto Nishiyama. Protein-protein interaction-mediated regulation of lysine biosynthesis of <i>Thermus thermophilus</i> through the function-unknown protein LysV. The Journal of General and Applied Microbiology. 2023
more...
MISC (51):
-
Genome-mining of amino group carrier protein-mediated machinery led to the discovery of an unprecedented hydrazine-forming enzyme in bacteria. Journal of Japanese Biochemical Society. 2020. 92. 1. 130-135
-
榊渓, 大石恵太, 清水哲, 小林一幾, 富田武郎, 富田武郎, 田中寛, 葛山智久, 葛山智久, 西山真, et al. シアノバクテリアのビオチン生合成経路に見出された新規脱水素酵素の機能と構造に関する研究. 日本農芸化学会大会講演要旨集(Web). 2019. 2019
-
寺本和矢, 野中健一, 塩見和朗, 西山真, 葛山智久. Trichoderma属糸状菌由来Brasilane型セスキテルペン合成酵素の機能解析. 日本農芸化学会大会講演要旨集(Web). 2018. 2018
-
寺本和矢, 石神健, 野中健一, 塩見和朗, 西山真, 葛山智久. Trichoderma属糸状菌由来テルペン合成酵素の探索と機能解析. 日本農芸化学会大会講演要旨集(Web). 2017. 2017
-
松田研一, 松田研一, 富田武郎, 志波優, 兼崎友, 吉川博文, 新家一男, 脇本敏幸, 葛山智久, 西山真. Genome Mining of Amino Group-Carrier Protein-Mediated Machinery: Insights into Biosynthesis of Unique Hydrazone Unit. 天然有機化合物討論会講演要旨集(Web). 2017. 59th
more...
Books (4):
-
Design of hydrophobic core of ┣DBE. coli(/)-┫DB malate dehydrogenase based on the side-chain packing
Pacific symposium on biocomputing '97 1997
-
Site-directed mutagenesis revealed role of subsite residues of ┣DBMucor(/)-┫DB ┣DBpusillus(/)-┫DB popsin in catahytic function
Asportic Proteinases: Structure, Function, Biology, and Biomedical Implications.(K. Takahashi ed.) Plenum Press, N.Y. 1995
-
Tyrosine 75 on the flap contributes to enhance catalytic efficiency of a fungal aspartic proteinase, ┣DBMucor(/)-┫DB ┣DBpusillus(/)-┫DB pepsin
Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications (K.Takahashi ed.))Plenum-Press N.Y. 1995
-
A yeast expression system and site-directed mutagenesis of a fungal aspartic proreinage, ┣DBMucor(/)-┫DB rennin
Structure and Functon of the Aspartic Proteinases(B. M. Dunn, ed. )Plenum Press, New York 1991
Lectures and oral presentations (13):
-
シクロラバンデュリル二リン酸合成酵素の結晶構造解析
(日本農芸化学会大会講演要旨集(Web) 2017)
-
シクロラバンデュリル2リン酸合成酵素の結晶構造解析
(イソプレノイド研究会例会講演要旨集 2016)
-
放線菌由来ジテルペン環化酵素CotB2が触媒する精巧な環化反応機構の解明
(日本農芸化学会大会講演要旨集(Web) 2016)
-
Corynebacterium glutamicum由来ホスホエノールピルビン酸カルボキシラーゼ(PEPC)のアセチル化制御はグルタミン酸生産に重要である
(日本農芸化学会大会講演要旨集(Web) 2016)
-
放線菌由来ジテルペン環化酵素CotB2の特異な環化反応機構の解明
(イソプレノイド研究会例会講演要旨集 2015)
more...
Works (4):
-
アスパラギン的プロテアーゼの構造と機能
1994 - 2000
-
耐熱性酵素の蛋白工学的研究
1994 - 2000
-
Structure and function of aspaitic proteineses
1994 - 2000
-
Protein engineering of thermostable enzymes
1994 - 2000
Education (3):
- - 1988 The University of Tokyo
- - 1986 The University of Tokyo Graduate School, Division of Agricultural Science
- - 1984 The University of Tokyo
Professional career (1):
Work history (6):
- 2003 - 現在 The University of Tokyo
- 1994 - 2003 The University of Tokyo
- 1988 - 1994 The University of Tokyo
- Professor
- Associate Professor
- Assistant Professor
Show all
Awards (1):
- 1993 - 農芸化学奨励賞(社団法人 日本農芸化学会)
Association Membership(s) (9):
アメリカ微生物学会
, アメリカ生化学分子生物学会
, 日本ゲノム微生物学会
, SOCIETY FOR ACTINOMYCETES JAPAN
, 日本ビタミン学会
, 日本生化学会
, 日本蛋白質科学会
, 日本分子生物学会
, 日本農芸化学会
Return to Previous Page