Rchr
J-GLOBAL ID：200901005494075318
Update date: Feb. 01, 2024
Takikawa Hajime
タキカワ ハジメ | Takikawa Hajime
Affiliation and department：
Job title：
Dean, Professor
Other affiliations (1)：
Research field (1)：
Gastroenterology
Research keywords (5)：
gastroenterology
, bile acid metabolism
, hepatic transport
, drug-induced liver injury
, autoimmune liver diseases
Research theme for competitive and other funds (19)：
- 2016 - 2019 Promotion of personalized medicine for lifestyle-related diseases by revealing bile acids, microbiota and cell signaling interaction
- 2009 - 2011 A study on the anti-cholestatic effect of phenyibutyrate
- 2005 - 2007 Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transporters
- 2004 - 2005 A study on the vesicular transport of canalicular transporters
- 2002 - 2003 A study on the urinary excretion of bileacids and organic anions in bileduct-ligated rats
- 2001 - 2002 Development of the system for prediction of drug-drug interactions in hepatobiliary transport process
- 2000 - 2001 A study on the Changes of localization of canalicular transporters in cholestasis.
- 1998 - 1999 Development of recombinant proteins with an aim to increase their therapeutic activity by the regulation of intracellular sorting
- 1998 - 1999 CHANGES OF BILIARY EXCRETORY FUNCTION AND CANALICULAR CARRIES IN INTRAHEPATIC CHOLESTASIS
- 1996 - 1997 Development of a method to predict in vivo drug metabolism and excretion from in vitro data with human hepatic tissues and/or recombinant proteins
- 1996 - 1996 エチニルエストラジオールによる胆汁うっ滞における各種肝指向性物質の胆汁中排泄
- 1995 - 1996 Development of Pharmacokinetic and Safety Assessment of in vivo Virus Infection and Vaccine Therapy
- 1995 - 1995 エストラジオール抱合体の胆汁中排泄機構 -P糖蛋白の関与に関するin vivoでの検討-
- 1994 - 1994 先天性黄疸ラットによる胆汁中排泄機構の検討
- 1993 - 1993 小胞輸送阻害剤の胆汁うっ滞に対する影響
- 1992 - 1993 Development of the drug delivery system for brain and cancer using the inhibitory effect of some drugs on the active efflux : Application of physiological pharmacokinetics.
- 1992 - 1992 ヒト肝3α-ヒドロキシステロイド脱水素酵素の胆汁酸結合能と酵素学的検討
- 1990 - 1990 先天性高ビリルビン血症ラットにおける胆汁酸輸送系の検討
- 1988 - 1988 ヒト肝サイトゾールY′胆汁酸結合蛋白の酵素学的検討
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Papers (263)：
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Ryosuke Nakamura, Noriaki Arakawa, Yoichi Tanaka, Nahoko Uchiyama, Akihiro Sekine, Yoichi Mashimo, Keiji Tsuji, Tatehiro Kagawa, Ken Sato, Masaaki Watanabe, et al. Significant association between HLA-B*35:01 and onset of drug-induced liver injury caused by Kampo medicines in Japanese patients. Hepatology research : the official journal of the Japan Society of Hepatology. 2023. 53. 5. 440-449
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Kensuke Kubota, Terumi Kamisawa, Takahiro Nakazawa, Atsushi Tanaka, Itaru Naitoh, Yusuke Kurita, Hajime Takikawa, Michiaki Unno, Shigeyuki Kawa, Atsushi Masamune, et al. Reducing relapse through maintenance steroid treatment can decrease the cancer risk in patients with IgG4-sclerosing cholangitis : based on a Japanese nationwide study. Journal of gastroenterology and hepatology. 2022. 38. 4. 556-564
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Toshihiko Arizumi, Susumu Tazuma, Hiroyuki Isayama, Takahiro Nakazawa, Toshio Tsuyuguchi, Hajime Takikawa, Atsushi Tanaka. Ursodeoxycholic acid is associated with improved long-term outcome in patients with primary sclerosing cholangitis. Journal of gastroenterology. 2022. 57. 11. 902-912
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Maeda Kazuya, Hajime Takikawa, Mitsuhiko Aiso, Kenji Tsuji, Tatehiro Kagawa, Masaaki Watanabe, Ken Sato, Shotaro Sakisaka, Yoichi Hiasa, Yoshiyuki Takei, et al. Frequency of null genotypes of glutathione S-transferase M1 and T1 in Japanese patients with drug-induced liver injury. Hepatology research : the official journal of the Japan Society of Hepatology. 2022. 52. 10. 882-887
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Hiroyuki Isayama, Susumu Tazuma, Norihiro Kokudo, Atsushi Tanaka, Toshio Tsuyuguchi, Takahiro Nakazawa, Kenji Notohara, Suguru Mizuno, Nobuhisa Akamatsu, Masahiro Serikawa, et al. Correction to: Clinical guidelines for primary sclerosing cholangitis 2017. Journal of gastroenterology. 2022. 57. 6. 453-454
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MISC (414)：
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柳澤 大輔, 阿部 浩一郎, 大隅 瞬, 大和 洸, 松本 康佑, 櫻井 美代子, 中村 直裕, 丸山 喬平, 三木 淳史, 青柳 仁, et al. 左頸部リンパ節腫大を契機に発見された食道神経内分泌癌の一例. Progress of Digestive Endoscopy. 2018. 93. Suppl. s95-s95
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板宮 孝紘, 浅子 来美, 菊地 弘敏, 奈倉 倫人, 内田 俊也, 滝川 一, 河野 肇. IV(A/C)+V型ループス腎炎に対し4剤併用療法を行なった1例. 板橋区医師会医学会誌. 2018. 22. 250-252
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田中 篤, 小森 敦正, 阿部 雅則, 稲生 実枝, 浪崎 正, 橋本 直明, 川田 一仁, 高橋 敦史, 二宮 匡史, 藤井 英樹, et al. 日本人PBC患者の予後予測におけるGlobeスコア・UK-PBCスコアの妥当性の検証. 肝臓. 2018. 59. Suppl.1. A454-A454
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田中 篤, 小森 敦正, 阿部 雅則, 稲生 実枝, 浪崎 正, 橋本 直明, 川田 一仁, 高橋 敦史, 二宮 匡史, 藤井 英樹, et al. 日本人PBC患者の予後予測におけるGlobeスコア・UK-PBCスコアの妥当性の検証. 肝臓. 2018. 59. Suppl.1. A454-A454
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Satoshi Mochida, Nobuaki Nakayama, Akio Ido, Kazuaki Inoue, Takuya Genda, Yasuhiro Takikawa, Isao Sakaida, Shuji Terai, Osamu Yokosuka, Masahito Shimizu, et al. Proposal of diagnostic criteria for acute-on-chronic liver failure (ACLF) in Japan. Acta Hepatologica Japonica. 2018. 59. 3. 155-161
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Patents (1)：
Lectures and oral presentations (1)：
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Characteristics of PSC in Japan. Symposium "PSC, a disease of omnifarious features and pathogenesis"
(th JSH Single Topic Conference "Liver and Immune Disorder: New Insights from Pathogenesis to Treatment" 2006)
Education (2)：
- - 1983 PhD (The University of Tokyo)
- - 1977 The University of Tokyo Faculty of Medicine
Professional career (1)：
- MD, PhD (The University of Tokyo)
Work history (9)：
- 2018/04 - 現在 Teikyo University Emeritus Professor, School of Medicine
- 2018/04 - 現在 Teikyo University Faculty of Medical Technology Dean
- 2013/04 - 2018/03 Teikyo University School of Medicine Dean
- 2011/04 - 2018/03 Teikyo University School of Medicine Professor and Chairman
- 1998/04 - 2018/03 Department of Medicine, Teikyo University School of Medicine Professor
- 1990 - 1998 Department of Medicine, Teikyo University Associate Professor
- 1987 - 1990 Teikyo University School of Medicine Senior Assistant Professor
- 1984 - 1986 University of California, Los Angeles
- 1980 - 1984 Second Department of Medicine, The University of Tokyo Medical Staff
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Committee career (6)：
Awards (2)：
- 1992 - 第1回ウルソ賞
- 1989 - 日本肝臓学会研究奨励賞
Association Membership(s) (7)：
The American Gastroenterology Association
, American Association of the Study of Liver DIseases
, 日本胆道学会
, 日本消化器内視鏡学会
, 日本内科学会
, 日本肝臓学会
, 日本消化器病学会
