Rchr

J-GLOBAL ID：200901005553859000 Update date: Aug. 10, 2024

Shoji Mikio

ショウジミキオ | Shoji Mikio

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Oral medicine

Research keywords (2)：口腔微生物学 , Oral Microbiology

Research theme for competitive and other funds (35)：

2023 - 2026 歯周病原菌プレボテラインターメディアの9型分泌機構依存性病原因子の解析
2022 - 2025 関節リウマチ患者由来ACPAと歯周病原菌関連タンパクによる歯周組織破壊機序の解明
2022 - 2025 歯周病原細菌などのバクテロイディア綱細菌固有のリポタンパク質輸送機構の解明
2022 - 2025 歯周病原細菌の9型分泌機構における選択的分泌メカニズムの解明
2020 - 2023 Elucidation of feedback regulation of the expression of the type IX secretion system (T9SS) of Porphyromonas gingivalis

2019 - 2023 Elucidation of the whole structure of type V pilus of a periodontal pathogen by using cryo-EM

2019 - 2022 Study of the transport mechanism of periodontal pathogen's pili proteins and search for the inhibitors

2017 - 2019 The mechanism for biofilm formation in periodontal pathogen, Prevotella intermedia.

2016 - 2019 Formation model of Bacteroidia bacteria pilus-X-ray crystal structure analysis and molecular reconstruction experiment-

2016 - 2019 Complete analysis of the composition and biosynthesis mechanism of specific O-polysaccharides present in a periodontal pathogen's LPS

2016 - 2018 Elucidation of cascade regulation by two different control systems of the type IX secretion system

2014 - 2017 The mechanism for haem acquisition in periodontal pathogen, Prevotella intermedia.

2014 - 2016 Biogenesis of sugar moiety of anionic lipopolysaccharide associated with CTD proteins

2013 - 2016 Supermolecule structure and mechanism of a novel bacterial protein secretion system, type IX secretion system

2013 - 2016 Study of localization mechanism of cell surface proteins in Porphyromonas gingivalis

2012 - 2014 Challenge to generate site-direct mutants of the periodontal pathogen Prevotella intermedia

2012 - 2013 Porphyromonas gingivalisの病原性に関わる多糖体生合成機構の解明とその役割

2011 - 2013 Characterization of the Porphyromonas gingivalis conjugative transposon CTnPg1: the gene transfer among oral bacteria and CTnPg1-like family CTns.

2011 - 2012 Analysis of a novel glycoprotein biosynthesis in the periodontalpathogen

2010 - 2011 複数の歯周病細菌に存在する新規蛋白質輸送機構の解明

2010 - 2011 Dual regulation of secretion system of periodontal virulence factors by novel two-component system and ECF sigma factor

2008 - 2010 Secretion mechanism of pathogenic proteases and adhesions in the periodontal pathogen Porphyromonas gingivalis.

2008 - 2010 The role of mobile genetic elements in Porphyromonas gingivalis strain diversity

2007 - 2007 歯周病原細菌の新規病原因子の探索ならびに細胞壁複合体のコンポーネント解析

2006 - 2007 歯周病関連細菌強毒株における新規病原性因子の同定と作用機構の解明

2005 - 2006 抗生物質耐性遺伝子をもたない歯周病原細菌生菌ワクチンの開発

2004 - 2005 口腔慢性細菌感染の心血管系および骨代謝系への影響とその病原因子に関する研究

2004 - 2005 Study on the oxidative stress responses of a major periodontopathogenic bacteria

2002 - 2004 歯周病原細菌Porphyromonasgingivalisにおける酸化ストレス防御因子の解析

2002 - 2004 Pest-sequencing analysis of periodontal pathogen Porphyromonas gingivalis : expression of its proteins by oral environmental fectors.

2003 - 2003 歯周病原細菌菌体表面タンパクの心血管系および骨代謝系に及ぼす影響

2002 - 2003 歯周病原細菌における酸化ストレス防御因子の機能およびその制御機構に関する研究

2002 - 2003 生菌ワクチン開発に向けた抗生物質耐性遺伝子をもたない歯周病原細菌変異株作製の試み

2002 - 2002 歯周病原細菌菌体表面タンパクの心血管系および骨代謝系に及ぼす影響

1999 - 2001 Study on oxidative stress protective factor in Porphyromonas gingivalis

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Papers (40)：

Yuko Sasaki, Mikio Shoji, Takayuki Sueyoshi, Satoshi Shibata, Takehiro Matsuo, Hideharu Yukitake, Matthias Wolf, Mariko Naito. A conditional gene expression system in Porphyromonas gingivalis for study of the secretion mechanisms of lipoproteins and T9SS cargo proteins. Molecular Oral Microbiology. 2023. 38. 4. 321-333
内藤真理子, 庄子幹郎, 佐藤啓子. 歯周病菌Prevotella intermediaにおけるType IX分泌系の重要な役割(The essential roles of Type IX secretion system in periodontal pathogen Prevotella intermedia). 日本細菌学雑誌. 2023. 78. 1. 79-79
Naito M, Shoji M, Sato K, Nakayama K. Insertional Inactivation and Gene Complementation of Prevotella intermedia Type IX Secretion System Reveals Its Indispensable Roles in Black Pigmentation, Hemagglutination, Protease Activity of Interpain A, and Biofilm Formation. Journal of Bacteriology. 2022. 204. 8. e00203-22
Veith P, Shoji M, Scott N, Reynolds EC. Characterizaton of the O-glycoproteome of Porphyromonas gingivalis. Microbiology Spectrum. 2022. 10. 1. e01502-21
Naito M, Belvin BR, Shoji M, Gui Q, Lewis JP. Insertional Inactivation of Prevotella intermedia OxyR Results in Reduced Survival with Oxidative Stress and in the Presence of Host Cells. Microorganisms. 2021. 9. 3. 551

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MISC (41)：

伊藤李香, 雪竹英治, 庄子幹郎, 藤原卓, 中山浩次, 内藤真理子. T9SSのカーゴタンパク質PorAとセンサーキナーゼPorYの結合によるT9SS遺伝子の発現制御(The T9SS cargo protein PorA binds to a sensor kinase PorY to regulate the T9SS gene expression). 日本細菌学雑誌. 2023. 78. 1. 76-76
Poster. Nippon Saikingaku Zasshi. 2023. 78. 1. 80-80
Poster. Nippon Saikingaku Zasshi. 2023. 78. 1. 88-88
富永孝志, 雪竹英治, 庄子幹郎, 内藤真理子. 歯周病原細菌Porphyromonas gingivalis9型分泌機構の必須分子PorEの機能解析. Journal of Oral Biosciences Supplement (Web). 2023. 2023
Mikio Shoji, Keiko Sato, Hideharu Yukitake, Yoshio Kondo, Yuka Narita, Tomoko Kadowaki, Mariko Naito, Koji Nakayama. Por Secretion System-Dependent Secretion and Glycosylation of Porphyromonas gingivalis Hemin-Binding Protein 35 (vol 6, e21372, 2011). PLOS ONE. 2018. 13. 8

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Patents (1)：

メンブレンヴェシクル

Lectures and oral presentations (74)：

歯周病細菌の9型分泌機構の解析
(第97回日本細菌学会総会 2024)
P. gingivalisが持つMfa線毛の構築機構および細菌間結合領域と宿主免疫回避に関与する構造
(第97回日本細菌学会総会 2024)
9型分泌機構関連タンパク質PorEの機能解析
(第97回日本細菌学会総会 2024)
Cryo-EM structure of the Mfa1 minor type V pilus from the periodontal pathogen Porphyromonas gingivalis
(2023)
Functional analysis of PorE, an essential molecule in the type 9 secretion system of the periodontal bacterium Porphyromonas gingivalis.
(2023)

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Works (5)：

歯周病原細菌におけるヘミン結合性外膜蛋白の遺伝生化学解析及び新規輸送機構の解明
2008 - 2010
ゲノム情報に基づいたP. gingivalisの宿主内での病原性因子調節機構の解析
2006 - 2008
歯周炎と心血管系および骨代謝疾患との関連性についての分子機構の解明
2005 - 2008
歯周病関連細菌強毒株における新規病原因子の同定と作用機構の解明
2006 - 2007
抗生物質耐性遺伝子を持たない歯周病原細菌生菌ワクチンの開発
2005 - 2007

Education (4)：

- 2001 九州大学大学院歯学研究院
- 2001 Kyushu University Graduate School, Division of Dental Research
- 1997 Kyushu University School of Dentistry
- 1997 Kyushu University Faculty of Dentistry

Professional career (1)：

歯学博士 (九州大学)

Awards (2)：

2012 - 日本細菌学会黒屋奨学賞
2004 - 国際歯科研究学会日本部会学術奨励賞

Association Membership(s) (2)：

歯科基礎医学会 , 日本細菌学会

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