Maruyama Satoshi

マルヤマサトシ | Maruyama Satoshi

Affiliation and department：
Job title： Assistant Professor
Other affiliations (1)：

医歯学総合病院講師

Research field (1)： Oral medicine (pathology)

Research keywords (4)： Oral Cancer , Oral Pathology , salivary gland tumor , Hypoxia

Research theme for competitive and other funds (34)：

2021 - 2024 死細胞貪食による口腔がん細胞活性化:脂質クオリティが果たす役割を探る
2021 - 2024 口腔扁平上皮癌の間質浸潤と側方上皮内進展:その相反的制御と分子基盤
2021 - 2024 細胞外基質環境下における腫瘍特異的なCD73誘導低酸素応答性増殖機構の解明
2019 - 2022 Basic research on multi-step tongue carcinogenesis model for realizing clinical sequence
2018 - 2021 Molecular regulation of actin polymerization and arrangement in the lateral front between oral squamous cell carcinoma and non-cancerous epithelium

2018 - 2021 Cell death-driven mechanisms for cancer progression: targeting the dying codes

2018 - 2021 Hypoxia-responsive CD73 promotes the growth and migration of pleomorphic adenoma cells

2015 - 2020 Gene network analyses of AD in periodontitis-affected gingival tissue

2014 - 2019 Pathogenesis of chewing-related oral cancer in Myanmar: a molecular pathoepidemiological study

2015 - 2018 Phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: a possible driving force for cancer progression

2015 - 2018 Hypoxia-responsive MYC promotes the survival and growth of pleomorphic adenoma cells in hypoxic conditions.

2015 - 2017 Molecular pathways and functional varieties of hemophagocytosis-induced keratinization in oral squamous cell carcinoma cells: from cell death to proliferation and invasion

2013 - 2017 Molecular patho-epidemiological study on the etiological background for oral superficial carcinoma among Asian ethnic groups

2013 - 2016 Proteome analysis of invasion starter molecules in oral squamous cell carcinoma

2012 - 2016 Elevated expression of Alzheimer disease related genes in periodontiti-affected gingival tissues

2011 - 2015 A molecular pathoepidemiological study on tobacco chewing-related oral cancer in Asian and African areas

2012 - 2015 Survival of salivary pleomorphic adenoma cells under the hypoxia-responsive extracellular matrix biosynthesis

2011 - 2013 Imaging of the microvascular distribution in the mandibular bone marrow using Dual Energy Computed Tomography Imaging; a trial run

2010 - 2012 Molecular mechanisms of ghost cell formation and calcification in calcifying cystic odontogenic tumor (CCOT) cell lines

2010 - 2011 Survival of salivary pleomorphic adenoma cells in hypoxic condition

2009 - 2011 Pathological roles of tissue inhibitors of metalloproteinases in the tissues of drug-induced fibrous gingival over growth.

2008 - 2011 Molecular patho-epidemiological study on oral superficial carcinoma in East Asia regions

2007 - 2010 Pathogenesis of oral cancer due to chewing habits spread in Asia to East Africa

2008 - 2009 Survival of salivary pleomorphic adenoma cells in hypoxic condition

2007 - 2008 The role of perlecan in the oral mucosa and the skin appendage-Transgenic mice overexpression of perlecan-

2006 - 2008 Molecular and pathology analyses for switching mechanism of stromal inducement in invasive oral carcinoma

2006 - 2007 唾液腺多形性腺腫の乏血性環境における増殖機構

2006 - 2007 歯原性角化嚢胞モデルとしてのMsx2ノックアウトマウスの顎骨嚢胞

2006 - 2007 Molecular pathological study of mechanism in malignant changes of benign odontogenic tumors

2005 - 2006 口腔粘膜上皮<胚細胞>の同定とその二方向性分化経路概念の確立

2005 - 2006 The role of basement membrane type heparan sulfate proteoglycan, perlecan, in epithelial morphogenesis -transgenic mice overexpressing perlecan in the epithelial cells-

2004 - 2006 Molecular biologic and pathologic analysis of Epstein-Barr virus infection related salivary lymphoepithelial carcinoma

2003 - 2006 Molecular pathological analysis of oral carcinoma caused by chewing habits in Asia

2004 - 2005 Molecular pathological study of mechanism in malignant changes of oral benign tumors

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Papers (110)：

Shinsuke Fujii, Kana Hasegawa, Takashi Maehara, Kari J Kurppa, Kristiina Heikinheimo, Kristy A. Warner, Satoshi Maruyama, Yudai Tajiri, Jacques E. Nör, Jun-ichi Tanuma, et al. Wnt/β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication. Pathology - Research and Practice. 2024. 155148-155148
Masaki Takamura, Yutaka Nikkuni, Takafumi Hayashi, Kouji Katsura, Hideyoshi Nishiyama, Manabu Yamazaki, Satoshi Maruyama, Jun-ichi Tanuma. Comparing the Diagnostic Accuracy of Ultrasonography, CT, MRI, and PET/CT in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma. Biomedicines. 2023. 11. 12. 3119-3119
Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Jun Cheng, Takashi Saku, Jun-ichi Tanuma. Hypoxia-Induced Biosynthesis of the Extracellular Matrix Molecules, Perlecan and Fibronectin, Promotes the Growth of Pleomorphic Adenoma Cells In Vitro Models. Biomedicines. 2023. 11. 11. 2981-2981
Toshiyuki Akimori, Manabu Yamazaki, Tatsuya Abé, Satoshi Maruyama, Kei Tomihara, Takeyasu Maeda, Jun-ichi Tanuma. Searching for new early detection markers of oral epithelial dysplasia and oral squamous cell carcinoma using oral liquid-based cytology. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023
羽賀健太, 山崎学, 丸山智, 阿部達也, 小林正治, 田沼順一. 光干渉断層撮影を用いた3次元口腔癌モデルにおける癌浸潤の定量解析(Quantitative analysis of cancer cell invasion on 3D in vitro oral cancer models using optical coherence tomography). 日本癌学会総会記事. 2023. 82回. 970-970

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MISC (100)：

河原田壮史, 河原田壮史, 丸山智, 山崎学, 阿部達也, 上野山敦士, 秋森俊行, 秋森俊行, 小島拓, 小島拓, et al. 口腔細胞診の従来法とLBC法において判定精度に影響を与える臨床病理学的因子の検討. 日本口腔診断学会総会プログラム・抄録集. 2022. 35th
河原田壮史, 丸山智, 笠原映, 山崎学, 林孝文, 片桐渉, 小林正治, 田沼順一. 舌腫瘍. 日本口腔診断学会雑誌. 2020. 33. 1. 81-81
新美奏恵, 船山昭典, 丸山智, 勝良剛詞, 新國農, 田沼順一, 林孝文, 小林正治. 舌上皮性異形成および上皮内癌と診断された病変の診断および治療の検討. 日本口腔診断学会雑誌. 2020. 33. 1. 126-126
笠原映, 山崎学, 丸山智, 勝良剛詞, 黒川亮, 河原田壮史, 林孝文, 高木律男, 田沼順一. 下顎骨内に発生した類皮嚢胞の1例. 日本口腔診断学会雑誌. 2020. 33. 1. 139-139
羽賀健太, 山崎学, 丸山智, 小林正治, 田沼順一. 癌関連線維芽細胞はSOX9を高発現させ口腔癌細胞の遊走および浸潤を促進する(Cancer-associated fibroblasts promote the migration and invasion of oral cancer cells via enhancing SOX9 expression). 日本癌学会総会記事. 2019. 78回. P-1258

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Education (2)：

2000 - 2004 Niigata University
1993 - 1999 Niigata University Faculty of Dentistry

Professional career (1)：

DDS, PhD (Niigata University)

Work history (4)：

2009/02 - 現在 Niigata University Medical and Dental Hospital
2005/05 - 2009/01 Niigata University Graduate School of Medical and Dental Sciences
2004/05 - 2005/04 Niigata University Graduate School of Medical and Dental Sciences
1999/05 - 2000/03 Hamamatsu University School of Medicine

Association Membership(s) (5)：

日本癌学会 , 日本病理学会 , 日本口腔外科学会 , 日本臨床口腔病理学会 , 歯科基礎医学会

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