Nakamura Michihiro

ナカムラミチヒロ | Nakamura Michihiro

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://ds.cc.yamaguchi-u.ac.jp/~nanomed1/index.html

Research field (6)： Nanobioscience , Anatomy , Nanomaterials , Other , Internal medicine - General , Science education

Research keywords (16)： Nanomedicine , Theranostics , organosilica particle , nanobio , Macrophage specificity , Radiotherapy , photodynamic therapy , Hyperthermia , drug delivery , 分子イメージング , バイオイメージング , Nanoparticle , antibody , Moodle , protein engineering , antibody engineering

Research theme for competitive and other funds (14)：

2020 - 2023 悪性黒色腫に高度に集積するマルチ温熱・放射線セラノスティックス・ナノ粒子の開発
2019 - 2021 病態制御に向けたエンドサイトーシス・タイピングによるマクロファージ特異性の解明
2016 - 2020 ヘテロ機能化セラノスティクス・ナノ粒子の腫瘍組織へのアクティブ・インベージョン
2015 - 2018 Development of multimodal theranostics tracer for personalized medicine in immuno-oncology
2013 - 2017 Creation of multi-theranostics nanoparticle for multi-strategic therpnosis

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Papers (72)：

Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura. Effects of Au States in Thiol-Organosilica Nanoparticles on Enzyme-like Activity for X-ray Sensitizer Application: Focus on Reactive Oxygen Species Generation in Radiotherapy. ACS Omega. 2023
Chika Kuroda, Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura. Size-dependent distribution of fluorescent thiol-organosilica particles in popliteal lymph nodes of mice. OpenNano. 2023. 9. 100114-100114
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura. Preparation of Fetal Bovine Serum-Copper Phosphate Hybrid Particles under Cell Culture Conditions for Cancer Cell Treatment. ACS Omega. 2022. 7. 33. 29495-29501
Chihiro Mochizuki, Yukihito Kayabe, Junna Nakamura, Masaya Igase, Takuya Mizuno, Michihiro Nakamura. Surface Functionalization of Organosilica Nanoparticles With Au Nanoparticles Inhibits Cell Proliferation and Induces Cell Death in 4T1 Mouse Mammary Tumor Cells for DNA and Mitochondrial-Synergized Damage in Radiotherapy. Frontiers in Chemistry. 2022. 10. 907642-907642
Michihiro Nakamura, Junna Nakamura, Chihiro Mochizuki, Chika Kuroda, Shigeki Kato, Tomohiro Haruta, Mayu Kakefuda, Shun Sato, Fuyuhiko Tamanoi, Norihiro Sugino. Analysis of cell-nanoparticle interactions and imaging of in vitro labeled cells showing barcorded endosomes using fluorescent thiol-organosilica nanoparticles surface-functionalized with polyethyleneimine. Nanoscale Advances. 2022. 4. 12. 2682-2703

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MISC (59)：

Michihiro Nakamura, Junna Nakamura, Chihiro Mochizuki, Shigeki Kato. Macrophage Specificity: Imaging and Characterization of Interaction between Macrophages and Fluorescent Organosilica Nanoparticles Depending on Surface Structure and Size. 2021
Michihiro Nakamura. In Vivo Imaging using Multifunctional Organosilica Nanoparticles. 14th International Symposium on Nanomedicine(ISNM2021). 2021
Organosilica Nanoparticles for Biomedical Applications toward Nano-Theranostics. 2021
Chika Kuroda, Michihiro Nakamura. Size-dependent Distribution of Fluorescent Thiol-Organosilica Particles in the Mouse Popliteal Lymph Nodes. The 8th Japan-China Symposium on Nanomedicine. 2021
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura. The synthesis of luminescence Au(I) complex-containing thiol-organosilica nanoparticles and their application for bioimaging. The 8th Japan-China Symposium on Nanomedicine. 2021

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Patents (19)：

観察方法およびマーカー
NANOFUNCTIONAL SILICA PARTICLES AND MANUFACTURING METHOD THEREOF
Fluorescent silica nano-particle, fluorescent nano-material, and biochip and assay using the same
ナノ機能性シリカ粒子およびその製造方法
新規なナノシリカ粒子の製造方法と用途

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Books (5)：

The Enzymes
Elsevier 2018 ISBN:9780128155202
ドラッグデリバリーシステム-バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発-
シーエムシー出版 2018
顕微鏡
公益社団法人日本顕微鏡学会 2017
Nakamura, M. Approaches to Biofunctionalization of Spherical Silica Nanomaterials. 109-161. In:Kumar C.S.S.R., editior. Nanomaterial for Life Sciences Volume 2: Nanostructured Oxides.
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany; 2009
炎症と免疫
先端医学社 1997

Lectures and oral presentations (160)：

Macrophage Specificity: Imaging and Characterization of Interaction between Macrophages and Fluorescent Organosilica Nanoparticles Depending on Surface Structure and Size
(Biophysical Society 67th Annual Meeting)
多機能ナノ粒子による細胞機能制御と新しい医学
(第6回ナノ材料科学・応用研究会 2023)
Multifunctional Organosilica Nanoparticles For Long-Term And Real-Time In Vivo Imaging
(15th International Symposium on Nanomedicine(ISNM2022))
蛍光細胞イメージングによる金ナノ粒子表面機能化有機シリカナノ粒子の4T1マウス乳がん細胞株への放射線治療効果の評価
(日本解剖学会第76回中国・四国支部学術集会)
ペルオキシダーゼ様活性を有するウシ胎児血清-リン酸銅ハイブリッド粒子触媒の細胞培養条件下での調製と細胞傷害活性の評価
(第130回触媒討論会)

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Works (4)：

蛍光シリカ球によるバイオアッセイ法の開発
2005 -
Organosilica Rhodamine B (100nm Diam.)
Organosilica FITC (100nm Diam.)
製品化・事業化情報: 蛍光オルガノシリカ粒子
https://www.tcichemicals.com/JP/ja/product/topics/Fluorescent_Organosilica_Particle

Education (2)：

- 1996 The University of Tokushima
- 1992 The University of Tokushima Faculty of Medicine School of Medicine

Professional career (2)：

M.D. Ph.D.
学士 (医学) (徳島大学)

Work history (7)：

2016 - 現在 Yamaguchi University
2008 - 2016 The University of Tokushima
2005 - 2008 徳島大学大学院ヘルスバイオサイエンス研究部形態情報医学分野講師
2004 - 2005 The University of Tokushima
2002 - 2004 米国国立衛生研究所国立がんセンター分子生物学研究室訪問研究員

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Committee career (4)：

2021 - 現在ナノ学会ナノバイオ・メディシン部会副部会長
2018 - 現在ナノ学会理事
2016 - 現在日本解剖学会代議員
2014 - 現在日本ナノメディシン交流協会理事

Awards (3)：

2017/04 - 公益財団法人宇部興産学術振興財団学術奨励賞
2012 - 公益財団法人康楽会康楽賞
2009/03 - 徳島大学医学部ベストティーチャー・オブ・ザ・イヤー2008

Association Membership(s) (5)：

日本ナノメディシン交流協会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , ナノ学会 , 日本解剖学会 , THE JAPANESE SOCIETY FOR BIOMATERIALS

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