Rchr
J-GLOBAL ID：200901005674347324
Update date: Jan. 30, 2024
Fujii Noriko
フジイ ノリコ | Fujii Noriko
Affiliation and department：
Job title：
Professor,Professor
Homepage URL (1)：
http://hlweb.rri.kyoto-u.ac.jp/fl/
Research field (1)：
Functional biochemistry
Research keywords (7)：
racemization
, Abnormal aggregation of protein
, cataract
, aging
, D-amino acid
, crystallin
, Biochemistry
Research theme for competitive and other funds (16)：
- 2018 - 2020 In-vivo Raman monitoring using molecular chirality as a diagnostic probe
- 2018 - 2019 細胞再現系での蛋白質の構造・ダイナミクスの解明
- 2015 - 2018 Development of Analysis Method for Reconbinant Biomacromolecular System utlizing Neutron Scattering
- 2013 - 2017 Mechanism of abnormal protein aggregation in the age-related diseases and the study of the restoration
- 2012 - 2015 Development of analysis method for dynamic state in high order structure of protein utilizing neutron scattering
- 2008 - 2012 Mechanism of abnormal protein aggregation and the study of the repair enzyme.
- 2007 - 2008 Study on Mechanism of Formation of High-Order Structure of Protein
- 2003 - 2005 水晶体培養細胞中のD-アミノ酸含有タンパク質及びストレス誘導タンパク質の解析
- 2002 - 2004 Characterization of D-amino acid containing protein from sun-damaged skin of elderly donors.
- 2000 - 2001 老化・紫外線・放射線によるタンパク質中のD-β-アスパラギン酸生成とその機構
- 2000 - 紫外線と皮フのD-アミノ酸
- 2000 - UV Radiation and D-amino Acid in Skin
- 1994 - タンパク質中のアスパラギン酸残基の反転と異性化
- 1994 - D-アミノ酸と老化
- 1994 - The simultaveous stereoinversion and isomerization of Asp residue in crystallin
- 1994 - D-amino acid and aging
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Papers (215)：
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Rintaro Inoue, Yusuke Sakamaki, Takumi Takata, Kathleen Wood, Ken Morishima, Nobuhiro Sato, Aya Okuda, Masahiro Shimizu, Reiko Urade, Noriko Fujii, et al. Elucidation of the mechanism of subunit exchange in αB crystallin oligomers. Scientific Reports. 2021. 11. 1
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Kosuke Magami, Naomi Hachiya, Kazuo Morikawa, Noriko Fujii, Takumi Takata. Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide. PloS one. 2021. 16. 4. e0250277
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Noriko Fujii, Takumi Takata, Ingu Kim, Toshiya Matsubara. Simultaneous and Rapid Detection of Multiple Epimers and Isomers of Aspartyl Residues in Lens Proteins Using an LC-MS-MRM Method. ACS omega. 2020. 5. 42. 27626-27632
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Takata T, Murakami K, Toyama A, Fujii N. Identification of Isomeric Aspartate residues in βB2-crystallin from Aged Human Lens. Biochim Biophys Acta-Proteins and Proteomics. 2018. 1866. 767-774
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Fujii N, Takata T, Fujii N, Aki K, Sakaue H. D-Amino acids in protein: The mirror of life as a molecular index of aging. BBA - Proteins and Proteomics. 2018. 1866. 840-847
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MISC (58)：
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R. Inoue, T. Takata, N. Fujii, N. Sato, Y. Oba, S. Takata, N. Fujii, M. Sugiyama. KINETICS OF SUBUNITS IN α-CRYSTALLIN AS STUDIED BY SMALL-ANGLE NEUTRON SCATTERING. 16th International Conference on Small-Angle Scattering. 2015
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Suzuki Yui, Sakaue Hiroaki, Fujii Noriko. 3 Analysis of aspartyl isomers in skin protein by LC-MS(General Session,The 39^<th> Annual Meeting of the SSOEL-Japan Program). Viva origino. 2014. 42. 3-3
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Aki Kenzo, Fujii Norihiko, Fujii Noriko. 43 Prediction of the isomerization rate of the amino acid residue in the protein during human lifespan using model peptides(Amino Acids and Evolution,General Contributions,The 38^<th> Annual Meeting of the SSOEL-Japan). Viva origino. 2013. 41. 47-47
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Kim Ingu, Fujii Norihiko, Fujii Noriko. 42 Effect of γ-ray irradiation on rat lens proteins(Amino Acids and Evolution,General Contributions,The 38^<th> Annual Meeting of the SSOEL-Japan). Viva origino. 2013. 41. 46-46
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Y. Ueki, N. Fujii, N. Fujii, Y. Oba, N. Sato, M. Sugiyama. Structural investigation of β-crystallin in an aqueous solution by small angle neutron scattering simulation. 15th International Small-Angle Scattering Conference, Sydney, Australia. 2012
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Books (15)：
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The Importance of the Idea of “Parachirality” in Life Science.
Elsevier Inc. 2017 ISBN:9780128128244
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D-Amino acid residues in proteins related to aging and age-related diseases and a new analysis of the isomers in proteins in "D-Amino acids:Physiology, Metabolism and Application"
Springer 2016 ISBN:9784431560753
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皮膚蛋白質中のアスパラギン酸残基異性体と紫外線による皮膚老化の関連性
シーエムシー出版 2015
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CSJ カレントレビュー17 「極限環境の生体分子-過酷な環境下での機能を科学する」 2014 日本化学会 放射線、紫外線照射、老化によるタンパク質への影響とその分析
日本化学会 2014
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D-amino-acid-containing proteins in living body--The Soai Reaction and Related Topic
Accademia Nazionale di Scienze Lettere e Arti Modena、 Italy. 2012
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Lectures and oral presentations (327)：
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生体分子ホモキラリティーのパラダイムシフト - D-アミノ酸研究の新展開
(第88回日本生化学会・第37回日本分子生物学会年会合同大会 2015)
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蛋白質異常凝集とD-アミノ酸 (八谷:アミロイド再考)
(第88回日本生化学会・第37回日本分子生物学会年会合同大会 2015)
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Crystallin racemization and insolubilization of lens proteins
(International Conference on the Lens 2015 2015)
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蛋白質異常凝集とD-アミノ酸
(第88回日本生化学会・第37回日本分子生物学会年会合同大会 2015)
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老化における蛋白質ホモキラリテイーの破れ
(さきがけ20周年記念講演会 さきがけ研究21「場と領域」研究領域 2015)
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Education (4)：
- - 1980 Tokyo Medical and Dental University
- - 1980 Tokyo Medical and Dental University Graduate School, Division of Medicine
- - 1974 Meiji University School of Agriculture
- - 1974 Meiji University Faculty of Agriculture
Professional career (1)：
Committee career (14)：
- 2004/10 - 現在 D-アミノ酸研究会運営委員長
- 2002/04 - 現在 生命の起原及び進化学会・事務局長
- 2007/04/01 - 2008/03/31 科学技術振興機構男女共同参画アドバイザリー委員会委員
- 2007/06 - - 日本白内障学会理事
- 2006/06 - - 日本女性科学者の会理事
- 2004 - D-アミノ酸研究会 運営委員長
- 2004 - 日本光医学・光生物学会 理事
- 2004 - 水晶体研究会 世話人
- 2004 - -日本光医学・光生物学会 理事
- 2004 - - 水晶体研究会 世話人
- 2003 - US-JAPAN CCRG (Cooperative Cataract Research Group) 世話人
- 2003 - - US-JAPAN CCRG (Cooperative Cataract Research Group) 世話人
- 1998/04 - 2002/03 生命の起原及び進化学会誌 "Viva Origino" 編集委員長
- 1990 - 生命の起原及び進化学会 編集委員長,運営委員,学会事務局責任者
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Awards (2)：
- 2015/07 - 日本光医学・光生物学会 第8回日本光医学・光生物学会 学会賞
- 1998 - 「日本女性科学者の会」奨励賞
Association Membership(s) (10)：
D-アミノ酸研究会
, 日本光医学・光生物学会
, 日本質量分析学会
, US-JAPAN CCRG (Cooperative Cataract Research Group)
, 水晶体研究会
, 日本放射化学会
, 日本生化学会
, 日本放射線影響学会
, International Society of Eye Research
, 生命の起原及び進化学会
