Rchr
J-GLOBAL ID：200901005964997640   Update date: Aug. 13, 2024

Hirose Akihiko

ヒロセ アキヒコ | Hirose Akihiko
Affiliation and department：
Chemicals Evaluation and Research Institute, Japan Chemical Assessment and Research Center

About Chemicals Evaluation and Research Institute, Japan Chemical Assessment and Research Center


Job title： Science Advisor
Homepage URL  (1)： https://www.cerij.or.jp/index.html
Research field  (8)： Hygiene and public health (non-laboratory) ,  Hygiene and public health (laboratory) ,  Healthcare management, medical sociology ,  Pharmaceuticals - health and biochemistry ,  Nanobioscience ,  Nanomaterials ,  Environmental effects of chemicals ,  Environmental effects of radiation
Research keywords  (4)： 安全性評価 ,  毒性学 ,  Safety Risk Assessment ,  Toxicology
Research theme for competitive and other funds  (40)：
  • 2018 - 2020 cfDNAおよびエクソソームRNAをバイオマーカーとした医薬品の次世代毒性評価法の開発
  • 2018 - 2020 医薬品の安全性及び品質確保のための医薬品規制に係る国際調和の推進に関する研究
  • 2018 - 2020 血液中の核酸をバイオマーカーに用いた化学物質の高感度な有害性評価に資する研究
  • 2018 - 2020 インシリコ予測技術の高度化・実用化に基づく化学物質のヒト健康リスクの評価ストラテジーの開発
  • 2018 - 2020 ナノマテリアル曝露による慢性影響の効果的評価手法開発に関する研究
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Papers (189)：
  • 田邊 思帆里, カデール・サビーナ, 小野 竜一, カブラル・オラシオ, 青柳 一彦, 広瀬 明彦, 横崎 宏, 佐々木 博己. 腸型及びびまん型胃がんにおけるcausalネットワークのマスターレギュレーター(The master regulators of causal networks in intestinal- and diffuse-type gastric cancer). 日本癌学会総会記事. 2023. 82回. 1778-1778
  • Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Edward J. Perkins, Hiroshi Yokozaki, Hiroki Sasaki. Regulation of Epithelial-Mesenchymal Transition Pathway and Artificial Intelligence-Based Modeling for Pathway Activity Prediction. Onco. 2023. 3. 1. 13-25
  • Motomu Shimizu, Motoki Hojo, Kiyomi Ikushima, Yukio Yamamoto, Ai Maeno, Yoshimitsu Sakamoto, Naozumi Ishimaru, Yuhji Taquahashi, Jun Kanno, Akihiko Hirose, et al. Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7. The Journal of toxicological sciences. 2023. 48. 12. 617-639
  • Aki Miyauchi, Toshi Akashi, Satoshi Yokota, Yuhji Taquahashi, Akihiko Hirose, Motoki Hojo, Hiroki Yoshida, Masahiko Kurokawa, Wataru Watanabe. Effects of inhalation of multi-walled carbon nanotube (MWCNT) on respiratory syncytial virus (RSV) infection in mice. The Journal of toxicological sciences. 2023. 48. 7. 411-420
  • Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, et al. Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats. Particle and Fibre Toxicology. 2022. 19. 1
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MISC (87)：
  • TANABE Shihori, QUADER Sabina, ONO Ryuichi, CABRAL Horacio, AOYAGI Kazuhiko, HIROSE Akihiko, PERKINS Edward J, YOKOZAKI Hiroshi, SASAKI Hiroki. Artificial Intelligence-Based Models to Predict the Activation State of Molecular Pathway in Diseases. 人工知能学会全国大会論文集(Web). 2023. 37th
  • TANABE Shihori, QUADER Sabina, ONO Ryuichi, CABRAL Horacio, AOYAGI Kazuhiko, HIROSE Akihiko, YOKOZAKI Hiroshi, SASAKI Hiroki. The prediction of therapeutic targets and microRNA network in the coronavirus pathogenesis pathway. 日本薬理学会年会要旨集(Web). 2022. 96th
  • Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki. Molecular network profiling in mesenchymal stem cells, diffuse- and intestinal-type gastric cancer. CANCER SCIENCE. 2021. 112. 592-592
  • NISHIMAKI-MOGAMI Tomoko, CUI Hongyan, SOGA Keisuke, TAMEHIRO Norimasa, ADACHI Reiko, HACHISUKA Akiko, HIROSE Akihiko, KONDO Kazunari. Identification of a chemical that represses multiwall carbon nanotube-stimulated IL-1β production. Annual Meeting of the Japanese Society of Toxicology. 2020. 45. Suppl. S136-S136
  • 田邊思帆里, 青柳一彦, QUADER Sabina, CABRAL Horacio, 小野竜一, 広瀬明彦, 横崎宏, 佐々木博己. Investigation of Wnt/beta-catenin signaling pathway in cancer and stem cells. 日本薬学会年会要旨集(Web). 2020. 140th
ｍore...
Books (1)：
  • 「4.リスクアセスメント・リスクマネージメント」、[新版]トキシコロジー、
    朝倉書店 2009 ISBN:9784254340259
Education (4)：
  • - 1990 Tohoku University
  • - 1990 Tohoku University Graduate School, Division of Medicine
  • - 1984 Toyama Medical and Pharmaceutical University
  • - 1984 Toyama Medical and Pharmaceutical University Faculty of Pharmaceutical Science
Work history (8)：
  • 2022/06 - 現在 Chemicals Evaluation and Research Institute, Japan Chemical Assessment and Research Center Science Advisor
  • 2022/04 - 2023/03 National Institute of Health Sciences Division of Risk Assessment Visiting Researcher
  • 2015/04 - 2022/03 国立医薬品食品衛生研究所 安全性予測評価部 部長
  • 2008 - :国立医薬品食品衛生研究所総合評価研究室室長
  • 1996 - :国立医薬品食品衛生研究所総合評価研究室主任研究官
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Committee career (1)：
  • 2002 - The Japanese Society of Toxicology Councilor
Awards (1)：
  • 2021/07 - Japanese Society of Toxicology The JSOT Award
Association Membership(s) (4)：
Society of Toxicology ,  日本内分泌撹乱化学物質学会 ,  日本食品化学学会 ,  日本毒性学会
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