Kikuchi Haruhisa

キクチハルヒサ | Kikuchi Haruhisa

Affiliation and department：
Job title： Assistant Professor
Homepage URL (2)： http://www.pha.keio.ac.jp/research/nm/index.html , http://www.pha.keio.ac.jp/en/research/index.html

Research field (3)： Environmental and pharmaceutical development resources , Pharmaceuticals - chemistry and drug development , Molecular biochemistry

Research keywords (3)：多様性指向型合成 , biologically active compounds , natural compounds

Research theme for competitive and other funds (32)：

2022 - 2025 免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索
2019 - 2023 細胞性粘菌由来の生物活性物質をシードとした創薬~新規抗がん剤と抗菌薬の開発~
2019 - 2022 Development of therapeutics for intractable infections using diverse natural products combined with stress-inductive biosynthesis and chemical modification
2019 - 2022 天然化合物を越える多様性を有した生物活性指向型化合物ライブラリーの構築
2016 - 2019 多様性拡大抽出物を基盤とした生物活性指向型天然化合物類縁体ライブラリーの創出

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Papers (131)：

Ryusei Araya, Shihu Men, Yoshinori Uekusa, Zaiqiang Yu, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minakawa, Shogo Kawaguchi, Ken-Ichi Furukawa, Yoshiteru Oshima, et al. The inhibitory effect of DIF-3 on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells. Journal of pharmacological sciences. 2024. 154. 3. 157-165
Yuzuru Kubohara, Yuko Fukunaga, Ayako Shigenaga, Haruhisa Kikuchi. Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake via Direct Inhibition of Mitochondrial Malate Dehydrogenase in Mouse 3T3-L1 Cells. International Journal of Molecular Sciences. 2024. 25. 3. 1889-1889
Yuzuru Kubohara, Yuko Fukunaga, Haruhisa Kikuchi, Hidekazu Kuwayama. Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells. Molecules. 2023. 28. 23. 7926-7926
Hidekazu Kuwayama, Haruhisa Kikuchi, Yuzuru Kubohara. Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum. Biology. 2023. 12. 6. 873-873
AIRI HIRAYAMA, HIROTAKA ISHIGAKI, KATSUNORI TAKAHASHI, YUSUKE MIURA, HARUHISA KIKUCHI, YUZURU KUBOHARA. <i>Dictyostelium</i> Differentiation-inducing Factor Derivatives Reduce the Glycosylation of PD-L1 in MDA-MB-231 Human Breast Cancer Cells. Juntendo Medical Journal. 2023

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MISC (13)：

Liu Xu, Zaiqiang Yu, Yoshinori Uekusa, Shogo Kawaguchi, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minakawa, Shigeru Motomura, Ken-Ichi Furukawa, Yoshiteru Oshima, et al. Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinicepolycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells(vol 149, pg 147, 2022). JOURNAL OF PHARMACOLOGICAL SCIENCES. 2023. 151. 1. 63-64
Gaowa Bai, Toshiro Niki, Haruhisa Kikuchi, Ayako Sumi, Nobuyuki Kobayashi, Takahiro Haruyama, Jing Zhang, Haorile Chagan-Yasutan, Toshio Hattori. New Development of Disaster-Related and Tropical Infectious Diseases Control. Reports - Medical Cases, Images, and Videos. 2020. 3. 1. 5-5
KUBOHARA Yuzuru, KIKUCHI Haruhisa, OSHIMA Yoshiteru. Derivatives of Dictyostelium differentiation-inducing factors inhibit serum-dependent cell migration of murine osteosarcoma LM8 cells. Juntendo Medical Journal. 2018
Y.Ando, K. Ota, I. Ito, H. Kikuchi, Y. Oshima, Y. Endo, K. Uwai, K. Tokuraku. Screening of amyloid-β aggregation inhibitors from aromatic low molecular compounds by a microliter-scale high-throughput screening system with quantam-dot nanoprobes. Neuroscience 2017. 2017
Yuichi Ando, Kiminori Ota, Ikuko Ito, Haruhisa Kikuchi, Yoshiteru Oshima, Yasuyuki Endo, Koji Uwai, Kiyotaka Tokuraku. Discovery of lead compounds targeting Amyloid-β aggregation from aromatic low-molecular compounds. Joint Seminar on Environmental Science and Disaster Mitigation Research 2017. 2017. 83-84

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Patents (24)：

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Books (1)：

細胞性粘菌:研究の新展開〜モデル生物,創薬資源,バイオ〜
アイピーシー出版 2012

Lectures and oral presentations (23)：

天然物創薬研究における細胞性粘菌
(第13回日本細胞性粘菌学会 2023)
Research results on anti-trypanosomal natural compounds at Keio University in the context of SATREPS-CHAGAS project
(Presentation of results of the Project for Integrated Research and Development towards Chagas Disease Control 2023)
天然資源探索と多様性指向型合成の複合による構造多様化合物群創製法の開発
(日本生薬学会第68年会 2022)
Development of Natural Product-Like Compound Library Based on Diversity-Enhanced Extracts
(The 5th Japan-Taiwan Joint Symposium for Pharmaceutical Sciences 2019)
創薬シーズを指向した天然物を越える構造多様化合物群の創出
(BINDS: ケミカルシーズ・リード探索ユニットジョイントシンポジウム 2019 IN 仙台 2019)

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Education (2)：

1998 - 1998 Tohoku University
1994 - 1998 Tohoku University Faculty of Phamacy

Professional career (1)：

Ph.D (Tohoku University)

Work history (5)：

2021/04 - 現在 Keio University Faculty of Pharmacy Professor
2009/04 - 2021/03 Tohoku University Graduate School of Pharmaceutical Sciences Assosiate Professor
2007/04 - 2009/03 Tohoku University Graduate School of Pharmaceutical Sciences Assistant Professor
1999/04 - 2007/03 Tohoku University Graduate School of Pharmaceutical Sciences Reserach Associate
1998/05 - 1999/03 Tohoku University Faculty of Pharmacy Reserach Associate

Committee career (6)：

2019/04 - 現在ナショナルバイオリソースプロジェクト細胞性粘菌運営委員
2019 - 現在日本細胞性粘菌学会評議員
2018 - 現在日本生薬学会代議員
2015 - 2016 日本細胞性粘菌学会評議員
2014 - 2014 日本細胞性粘菌学会第4回例会大会委員長

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Awards (5)：

2022 - 日本生薬学会日本生薬学会学術貢献賞
2013 - MCS Award, Division of Medicinal Chemistry, The Pharmaceutical Society of Japan
2010 - 9th Intelligent Cosmos Encouragement Prize
2006 - Award for Young Scientists of Tohoku Division of The Pharmaceutical Society of Japan
2004 - Award of 46th Symposium on the Chemistry of Natural Products

Association Membership(s) (4)：

Japanese Society for the Study of Cellular Slime Molds , THE JAPANESE SOCIETY OF PHARMACOGNOSY , 有機合成化学協会 , 日本薬学会

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