Rchr
J-GLOBAL ID：200901006040266662   Update date: Oct. 05, 2024

AKIRA TOGAYACHI

トガヤチ アキラ | AKIRA TOGAYACHI
Affiliation and department：
Soka University Glycan & Life System Integration Center (GaLSIC)

About Soka University Glycan & Life System Integration Center (GaLSIC)


Job title： Professor
Research field  (2)： Cell biology ,  Functional biochemistry
Research keywords  (6)： glycoyltransferase ,  immunology ,  glycobiomarker ,  glycoproteomics ,  glycogene ,  glycobiology
Research theme for competitive and other funds  (7)：
  • 2023 - 2026 Construction of Glycobiomarker Deevelopment Technology Driven by Glycoinformatics
  • 2022 - 2025 Functional analysis of O-GlcNAc modification that regulates the liquid-liquid phase separation in pluripotent stem cells.
  • 2021 - 2024 子宮頸管粘液を用いたレクチン、糖鎖による子宮体がんの新規診断検査法の開発
  • 2015 - 2019 Development of new diagnostic and therapeutic biomarkers for cervical adenocarcinoma using high sensitivity sugar chain analysis system
  • 2015 - 2018 Elucidation of biological function of glycan by integrated omics analysis based on glycoproteome.
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Papers (74)：
  • Kei-Ichiro Inamori, Katsuya Nakamura, Fumi Shishido, Jia-Chen Hsu, Masakazu Nagafuku, Takahiro Nitta, Junji Ikeda, Hidekane Yoshimura, Minori Kodaira, Naomi Tsuchida, et al. Functional evaluation of novel variants of B4GALNT1 in a patient with hereditary spastic paraplegia and the general population. Frontiers in neuroscience. 2024. 18. 1437668-1437668
  • Yusuke Matsui, Akira Togayachi, Kazuma Sakamoto, Kiyohiko Angata, Kenji Kadomatsu, Shoko Nishihara. Single-cell Glycogenomics Deciphers Links Between Altered Transcriptional Regulation and Aberrant Glycosylation in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2023
  • Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Taiga Aoki, Jun-Ichi Furukawa, Akira Togayachi, Kiyoko Aoki-Kinoshita, Jin-Ichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, et al. Predicting the pathogenicity of missense variants based on protein instability to support diagnosis of patients with novel variants of ARSL. Molecular Genetics and Metabolism Reports. 2023. 37. 101016-101016
  • Akira Togayachi, Takashi Kudo. Enzyme assay of α1,3/4-fucosyltransferase. Glycoscience Protocols (GlycoPODv2). 2023
  • Akira Togayachi, Takashi Sato, Tomomi Kubota, Hisashi Narimatsu. General methods for detection of enzyme reaction products of polypeptide N-acetylgalactosaminyltransferase, β1,3-glycosyltransferase, and β1,4-glycosyltransferases. Glycoscience Protocols (GlycoPODv2). 2023
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MISC (246)：
  • 稲森啓一郎, 宍戸史, 許家甄, 永福正和, 新田昂大, 中村勝哉, 中村勝哉, 土田奈緒美, 池田淳司, 小平農, et al. 神経変性症患者および一般住民に見出された新規B4GALNT1(GM2合成酵素)バリアントの機能解析. 脂質生化学研究. 2024. 66
  • 稲森啓一郎, 宍戸史, HSU Jia-Chen, 永福正和, 新田昂大, 中村勝哉, 中村勝哉, 土田奈緒美, 池田淳司, 小平農, et al. Functional analysis of novel mutation and variants in the hereditary spastic paraplegia causative gene B4GALNT1. 日本糖質学会年会要旨集. 2023. 42nd
  • 青木英莉子, 真鍋法義, 大野詩歩, 青木大芽, 古川潤一, 栂谷内晶, 木下聖子, 井ノ口仁一, 黒澤健司, 要匡, et al. A new method for diagnosis and predicting X-linked recessive brachytelephalangic chondrodysplasia punctata: Computational analysis and identification of novel missense mutation. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 要匡, 太田隼人, 柳久美子, 花松久寿, PECORI Federico, 古川潤一, 山口芳樹, 上原朋子, 井ノ口仁一, 木下聖子, et al. Genes to diagnosis and therapy in glycogenomics disorders: The example of GDP-fucose transporter deficiency, a rare disease. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 栂谷内晶. Application of the Glycoproteomics-based Strategy for Development of Serum Glycobiomarkers. 創価大学糖鎖生命システム融合研究所(GaLSIC)所報(Web). 2022. 1. 17-20
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Patents (56)：
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Lectures and oral presentations  (7)：
  • Genes to diagnosis and therapy in glycogenomics disorders:ヒト糖鎖関連希少疾患GDP-フコース輸送体欠損症を例として
    (第45回日本分子生物学会年会、(ワークショップ3PW-05)糖鎖が関わる難治性・希少疾患:基礎から診断・治療まで 2022)
  • X連鎖性劣性末節骨短縮型点状軟骨異形成症の予測と診断: コンピューター解析と新規ミスセンス変異の同定
    (第45回日本分子生物学会年会、(ワークショップ3PW-05)糖鎖が関わる難治性・希少疾患:基礎から診断・治療まで 2022)
  • Application of the Glycoproteomics-based Strategy for Development of Serum Glycobiomarkers.
    (The 94th Annual Meeting of the Japanese Biochemical Society 2021)
  • Comprehensive extraction and analysis of the whole human glycan-related gene variant
    (The 40th Annual Meeting of Japanese Society of Carbohydrate Research 2021)
  • Development of serum marker for ovarian clear cell carcinoma;construction of WFA+-celluloplasmin assay system using recombinant;modified lectin;surface plasmon field-enhanced fluorescence spectroscopy.
    (The 41st Japan Society for Moleculer Tumor Marker Reseach. 2021)
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Professional career (1)：
  • 博士(薬学) (東京大学大学院 薬学系研究科)
Committee career (3)：
  • 2023/02 - 現在 日本糖鎖科学コンソーシアム 事務局長
  • 2022/02 - 現在 Japan Consortium for Glycobiology and Glycotechnology
  • 2020/07 - 現在 The Japanese Society of Carbohydrate Research; JSCR Councilor
Awards (3)：
  • 2015/04 - 産業技術総合研究所 産業技術総合研究所 理事長賞(本格研究)
  • 2011/07 - 日本糖質学会 第14回 糖質学会奨励賞(生物系)
  • 2006/08 - 日本糖質学会 第26回日本糖質学会年会・弟10回ポスター賞(生物系)
Association Membership(s) (7)：
日本肝臓学会 ,  The Japan Consortium for Glycobiology and Glycotechnology (JCGG) ,  日本免疫学会 ,  日本分子腫瘍マーカー研究会 ,  日本癌学会 ,  日本糖質学会 ,  日本生化学会
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