Rchr
J-GLOBAL ID:200901007190597701   Update date: Sep. 30, 2019

HIJIKATA Makoto

ヒジカタ マコト | HIJIKATA Makoto
Affiliation and department:
Job title: Associate Professor,Associate Professor
Research field  (1): Virology
Research keywords  (3): Virology ,  Molecular Biology ,  Cell Biology
Research theme for competitive and other funds  (4):
  • 1990 - Study on mechamism of proliferation of hepatitis C virus
  • 1990 - Study on mechanism of carcinogenesis caused by hepatitis C virus
  • 1997 - Functional analysis of p73 gene related with tumor suppressor gene, p53
  • 1999 - Functional Analysis of β-catenin in Hepato Cellular Carcinogenesis
Papers (122):
  • Nio Y, Sasai M, Akahori Y, Okamura H, Hasegawa H, Oshima M, Watashi K, Wakita T, Ryo A, Tanaka Y, Hijikata M. Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems. Antiviral research. 2019. 169. 104537
  • Osawa M, Uchida T, Imamura M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Ishida Y, Tateno C, Miyayama Y, Hijikata M, Chayama K. Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice. The Journal of general virology. 2019. 100. 7. 1123-1131
  • Hishiki T, Kato F, Nio Y, Watanabe S, Wen Tan NW, Yamane D, Miyazaki Y, Lin CC, Suzuki R, Tajima S, Lim CK, Saijo M, Hijikata M, Vasudevan SG, Takasaki T. Stearoyl-CoA desaturase-1 is required for flavivirus RNA replication. Antiviral research. 2019. 165. 42-46
  • ALY Hassan Hussein, SUZUKI Junya, WATASHI Koich, CHAYAMA Kazuaki, HOSHINO Shin-ichi, HIJIKATA Makoto, KATO Takanobu, WAKITA Takaji. RNA exosome complex regulates stability of hepatitis B virus's X-mRNA transcript in a non-stop mediated (NSD) RNA quality control mechanism. Journal of Biological Chemistry. 2016. 291. 31. 15958-15974
  • Takeuchi F, Ikeda S, Tsukamoto Y, Iwasawa Y, Qihao C, Otakaki Y, Ryota O, Yao WL, Narita R, Makoto H, Watashi K, Wakita T, Takeuchi K, Chayama K, Kogure A, Kato H, Fujita T. Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor. PloS one. 2019. 14. 2. e0212233
more...
MISC (43):
  • MIYAYAMA Yohei, CHAYAMA Hiromi., MIKI Daiki., IMAMURA Michio, CHAYAMA Kazuaki, HIJIKATA Makoto. Development of novel recombinant HCV1b culture system. 第65回日本ウイルス学会学術集会.大阪. 2017
  • OKAMURA Hitomi, NIO Yasunori, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto. Fatty acids synthesized from cellular fatty acid synthesis pathway play roles in hepatitis B virus production. 第65回日本ウイルス学会学術集会.大阪. 2017
  • OKAMURA Hitomi, MIYAYAMA Yohei., AKAHORI Yuichi., HIJIKATA Makoto. Modulation of HBV life cycle by Sulforaphane. 2017 International meeting on the molecular biology of hepatitis B viruses, Washington D.C., USA. 2017
  • OKAMUARA Hitomi., NIO Yasunori., WATASHI Koichi., WAKITA Takaji., HIJIKATA Makoto. Fatty acids with certain carbon chain length can support hepatitis B virus production. 2017 International meeting on the molecular biology of hepatitis B viruses, Washington D.C., USA. 2017
  • AKAHORI Yuichi, KATO Hiroki, FUJITA Takashi, MORIISHI Koji, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto. Development of novel hepatitis B virus culture system using immortalized human hepatocytes. 2016
more...
Patents (2):
  • Method for Producing Epithelial Stem Cells
  • A method for preventing or treating hepatitis C infections or HCV induced disorders
Lectures and oral presentations  (5):
  • 血液由来HCVの感染増殖を再現する新しい培養細胞系の構築
    (第18回広島肝臓研究会 2009)
  • ウイルス培養系を用いたC型肝炎ウイルスの性状と病原性の解明、 臨床分離HCV株の培養と性状
    (第58回日本ウイルス学会学術総会 2010)
  • C型肝炎治療薬の新たな分子標的の探索
    (第13回肝疾患フォーラム学術集会 2013)
  • HCV培養系開発から見出された新たなHCV薬の標的
    (第27回広島肝臓研究会学術講演会 2014)
  • 肝炎ウイルス培養系の開発とその応用
    (Meet the expert 2016)
Education (2):
  • - 1982 Shinshu University Faculty of Science
  • - 1988 Shinshu University Graduate School, Division of Medicine
Professional career (2):
  • Doctor of Medicine (Shinshu University)
  • Master of Science (Shinshu University)
Work history (5):
  • 1988 - 1991 Research Resident, the Foundation for Promotion of Cancer Research, Japan
  • 1991 - 1994 Research Associate, Virology Division, National Cancer Center Research Institute
  • 1994 - 1996 Postdoctoral Fellow, The Rockefeller University, NY, USA
  • 1994 - 1997 Section Head, National Cancer Center Research Institute
  • 1997 - Associate Professor, Institute for Virus Research, Kyoto University
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