Rchr
J-GLOBAL ID：200901007190597701
Update date: Sep. 01, 2020
Hijikata Makoto
ヒジカタ マコト | Hijikata Makoto
Affiliation and department：
Job title：
Associate Professor,Associate Professor
Research field (1)：
Virology
Research keywords (6)：
細胞生物学
, 分子生物学
, ウイルス学
, Cell Biology
, Molecular Biology
, Virology
Research theme for competitive and other funds (8)：
- 1999 - 肝発がんにおけるβカテニンの機能解析
- 1999 - Functional Analysis of β-catenin in Hepato Cellular Carcinogenesis
- 1997 - がん抑制遺伝子p53関連遺伝子p73の機能解析
- 1997 - Functional analysis of p73 gene related with tumor suppressor gene, p53
- 1990 - C型肝炎ウイルスによる発がん機構に関する研究
- 1990 - C型肝炎ウイルスの増殖機構に関する研究
- 1990 - Study on mechanism of carcinogenesis caused by hepatitis C virus
- 1990 - Study on mechamism of proliferation of hepatitis C virus
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Papers (129)：
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Yasunori Nio, Machiko Sasai, Yuichi Akahori, Hitomi Okamura, Hikari Hasegawa, Mizuki Oshima, Koichi Watashi, Takaji Wakita, Akihide Ryo, Yasuhito Tanaka, et al. Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems. Antiviral research. 2019. 169. 104537-104537
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Osawa M, Uchida T, Imamura M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, et al. Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice. The Journal of general virology. 2019. 100. 7. 1123-1131
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Takayuki Hishiki, Fumihiro Kato, Yasunori Nio, Satoru Watanabe, Nicole Wei Wen Tan, Daisuke Yamane, Yasuyuki Miyazaki, Chun-Chieh Lin, Rieko Suzuki, Shigeru Tajima, et al. Stearoyl-CoA desaturase-1 is required for flavivirus RNA replication. Antiviral research. 2019. 165. 42-46
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Takeuchi F, Ikeda S, Tsukamoto Y, Iwasawa Y, Qihao C, Otakaki Y, Ryota O, Yao WL, Narita R, Makoto H, et al. Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor. PloS one. 2019. 14. 2. e0212233
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Yasunori Nio, Yuichi Akahori, Hitomi Okamura, Koichi Watashi, Takaji Wakita, Makoto Hijikata. Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide. Biochemical and Biophysical Research Communications. 2018. 501. 3. 820-825
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MISC (72)：
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MIYAYAMA Yohei, CHAYAMA Hiromi, MIKI Daiki, IMAMURA Michio, CHAYAMA Kazuaki, HIJIKATA Makoto. Development of novel recombinant HCV1b culture system. 第65回日本ウイルス学会学術集会.大阪. 2017
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OKAMURA Hitomi, NIO Yasunori, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto. Fatty acids synthesized from cellular fatty acid synthesis pathway play roles in hepatitis B virus production. 第65回日本ウイルス学会学術集会.大阪. 2017
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OKAMURA Hitomi, MIYAYAMA Yohei, AKAHORI Yuichi, HIJIKATA Makoto. Modulation of HBV life cycle by Sulforaphane. 2017 International meeting on the molecular biology of hepatitis B viruses, Washington D.C., USA. 2017
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OKAMUARA Hitomi, NIO Yasunori, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto. Fatty acids with certain carbon chain length can support hepatitis B virus production. 2017 International meeting on the molecular biology of hepatitis B viruses, Washington D.C., USA. 2017
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AKAHORI Yuichi, KATO Hiroki, FUJITA Takashi, MORIISHI Koji, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto. Development of novel hepatitis B virus culture system using immortalized human hepatocytes. 2016
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Patents (14)：
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Method for Producing Epithelial Stem Cells
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内胚葉性幹細胞の製造方法
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感染性C型肝炎ウイルス粒子の製造方法、およびその利用
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肝炎ウイルスの増殖方法、及びその利用
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上皮系体性幹細胞の製造方法
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Books (4)：
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3D細胞培養系を用いた患者血液由来HCV培養
肝・胆・膵 57 (5), 679-687 2008 2008
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HCVと肝発癌
医学のあゆみ 224 (9), 693-698 2008 2008
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C型肝炎ウイルスの生活環と発がん
公益社団法人 日本農芸化学会 2008
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C型肝炎ウイルス(共著)
アイピーシー, 2000
Lectures and oral presentations (6)：
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Development and application of hepatitis virus culture system
(Meet the expert 2016)
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HCV培養系開発から見出された新たなHCV薬の標的
(第27回広島肝臓研究会学術講演会 2014)
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C型肝炎治療薬の新たな分子標的の探索
(第13回肝疾患フォーラム学術集会 2013)
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Novel targets for anti HCV drugs preventing infectious virus particle production.
(The 3rd JCA-AACR Special Joint Conference, The Latest Advances in Liver Cancer Research: From Basic Science to Therapeutics, Chiba, Japan 2011)
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ウイルス培養系を用いたC型肝炎ウイルスの性状と病原性の解明、 臨床分離HCV株の培養と性状
(第58回日本ウイルス学会学術総会 徳島 2010)
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Education (4)：
- - 1988 Shinshu University
- - 1988 Shinshu University
- - 1982 Shinshu University
- - 1982 Shinshu University
Professional career (2)：
- Doctor of Medicine (Shinshu University)
- Master of Science (Shinshu University)
Work history (9)：
- 1994 - 1997 国立がんセンター研究所室長
- 1994 - 1997 Section Head, National Cancer Center Research Institute
- 1997 - - Associate Professor, Institute for Virus Research, Kyoto University
- 1994 - 1996 米国ロックフェラ?大学博士研究員
- 1994 - 1996 Postdoctoral Fellow, The Rockefeller University, NY, USA
- 1991 - 1994 国立がんセンター研究所研究員
- 1991 - 1994 Research Associate, Virology Division, National Cancer Center Research Institute
- 1988 - 1991 財団法人がん研究振興財団リサーチレジデント
- 1988 - 1991 Research Resident, the Foundation for Promotion of Cancer Research, Japan
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Association Membership(s) (4)：
日本生化学会
, 日本癌学会
, 日本分子生物学会
, 日本ウイルス学会
