Tohoku University Graduate School of Life Sciences Department of Biomolecular Sciences Division of Molecular Biosystems Laboratory of Molecular and Cellular Biology
About Tohoku University Graduate School of Life Sciences Department of Biomolecular Sciences Division of Molecular Biosystems Laboratory of Molecular and Cellular Biology
Research theme for competitive and other funds (19):
2014 - 2017 Elucidation of pathogenic mechanism of Parkinson's disease through analysis of IPAS, a novel substrate of Parkin
2006 - 2007 Visualization of the VBC complex in living cells by FLIM-FRET
2006 - 2007 外来薬物による遺伝子発現誘導における転写因子複合体の機能解析
2006 - 2007 生細胞でのAhリセプター転写複合体のイメージングと活性化機構
2005 - 2006 FRETによる単一生細胞でのPMLボディ生理機能の可視化
2005 - 2005 FLIM-FRET測定とRNAiを用いた薬物による遺伝子発現誘導機構の解析
2005 - 2005 発がん物質による転写活性化過程の単一生細胞内イメージング
2003 - 2005 Real-time observation of interactions between trancription factors containing PAS domains
2000 - 2000 色素細胞分化におけるWntシグナル関連因子とMITFとの機能的相互作用
1999 - 2000 小眼球症関連転写因子による細胞分化と形質発現の制御機構
1998 - 1999 腸管筋層における転写因子MITF isoformによるC-KIT発現調節
1998 - 1999 Molecular basis of the structural and functional multiplicity of microphthalmia-associated transcription factor
1998 - 1998 小眼球症関連転写因子MITFの細胞分化における機能的多様性
1997 - 1998 個体老化のモデルとしての白髪形成の分子機構の解明
1997 - 1998 転写因子MITFによる色素細胞分化とメラニン生合成の制御機構の解明
1996 - 1997 Molecular mechanisms of pigment cell differentiation.
1995 - 1996 Development of a new method for detecting gene expression in a single cell and its medical application.
1995 - 1995 メラニン生成関連遺伝子の色素細胞特異的発現に関わる転写因子の解析
1994 - 1994 ヒトメラニン生成関連遺伝子のメラノサイト特異的転写の分子機構
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Papers (71):
Sho Tabata, Yasushi Kojima, Takeharu Sakamoto, Kaori Igarashi, Ko Umetsu, Takamasa Ishikawa, Akiyoshi Hirayama, Rie Kajino-Sakamoto, Naoya Sakamoto, Ken-Ichi Yasumoto, et al. L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis. Oncogene. 2023. 42. 16. 1294-1307
Shuya Kasai, Xianyu Li, Satoru Torii, Ken-ichi Yasumoto, Kazuhiro Sogawa. Direct protein-protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death. Cell Death Discovery. 2021. 7. 1. 300-300
Shuya Kasai, Ken-ichi Yasumoto, Kazuhiro Sogawa. Attenuation of inhibitory PAS domain protein-induced cell death by synthetic peptides derived from Mcl-1 transmenbrane domain. Cell Death Discovery. 2021. 7. 1. 92
Satoru Torii, Shuya Kasai, Tatsushi Yoshida, Ken-Ichi Yasumoto, Shigeomi Shimizu. Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson's Disease and Its Substrate-Involved Mouse Experimental Models. International journal of molecular sciences. 2020. 21. 4