Kubo Yoshiyuki

クボヨシユキ | Kubo Yoshiyuki

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.bbb-teikyo.com/

Research field (4)： Clinical pharmacy , Pharmacology , Pharmaceuticals - health and biochemistry , Functional biochemistry

Research keywords (15)： Blood-testis barrier , blood-retinal barrier , blood-brain barrier , 腎再吸収 , 消化管吸収 , 血液組織関門 , オーファン分子 , トランスポーター , 薬物動態 , 生体膜 , Orphan molecule , Blood-tissue barrier , Xenobiotics , Cell membrane , Transporter

Research theme for competitive and other funds (13)：

2017 - 2020 血液網膜関門カチオン性薬物エフラックス機構の分子機序解明と創薬への展開
2014 - 2017 新規カチオン性薬物輸送機構におけるオーファン分子の役割解明と創薬への展開
2011 - 2013 組織関門における新規インフラックス分子実体の同定と薬効・毒性予測への展開
2010 - 2011 ファーマコプロテオミクス的手法による機能性タンパク質の定量的局在解析
2010 - 2011 Quantitative Analysis of Membrane Proteins with Pharmacoproteomic Approach

Show all

Papers (110)：

Tomoko Yamaguchi, Daiki Sako, Toshiki Kurosawa, Misae Nishijima, Ayaka Miyano, Yoshiyuki Kubo, Sumio Ohtsuki, Kenji Kawabata, Yoshiharu Deguchi. Development and Functional Evaluation of MDR1-Expressing Microvascular Endothelial-Like Cells Derived from Human iPS Cells as an In Vitro Blood-Brain Barrier Model. Journal of pharmaceutical sciences. 2023
Toshiki Kurosawa, Daiki Sako, Yoshiyuki Kubo, Yoshiharu Deguchi. ヒトiPS細胞由来血液脳関門モデルの構築とトランスポーター機能評価. Drug Delivery System. 2023. 38. 2. 117-124
Toshiki Kurosawa, Yuma Tega, Yasuo Uchida, Kei Higuchi, Hidetsugu Tabata, Takaaki Sumiyoshi, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi. Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier. Pharmaceutics. 2022. 14. 8. 1683-1683
Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi. Correction to: Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Pharmaceutical research. 2022
Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi. Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Pharmaceutical research. 2022

ｍore...

MISC (30)：

久保義行, 細谷健一. 血液網膜関門における網膜への薬物輸送メカニズム. Pharm stage. 2017. 17. 1. 73-79
Takuya Usui, Yoshiyuki Kubo, Shin-ichi Akanuma, Ken-ichi Hosoya. INVOLVEMENT OF PMAT IN HISTAMINE EFFLUX FROM THE CEREBROSPINAL FLUID ACROSS THE BLOOD-CEREBROSPINAL FLUID BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 291-292
Yuma Tega, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya. NICOTINE TRANSPORT IN THE RAT BLOOD-BRAIN BARRIER AND LIVER: INVOLVEMENT OF THE PROTON-COUPLED ORGANIC CATION ANTIPORTER. DRUG METABOLISM REVIEWS. 2015. 47. 294-294
Yoshiyuki Kubo, Ai Tsuchiyama, Yoshimi Shimizu, Shin-ichi Akanuma, Ken-ichi Hosoya. THE BLOOD-TO-RETINA TRANSPORT OF CLONIDINE AT THE INNER BLOOD-RETINAL BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 292-293
赤沼伸乙, 久保義行, 細谷健一. タウリンの体内動態とその動態にトランスポーターが果たす役割 (特集第1回国際タウリン研究会日本部会プロシーディングス). タウリンリサーチ = Japanese journal of taurine research. 2015. 1. 1. 44-46

ｍore...

Patents (2)：

辻彰, 加藤将夫, 久保義行, 金子周一, 加賀谷尚史, 曽我朋義「エルゴチオネインを利用したクローン病の診断および治療」
辻彰, 薮内光, 加藤将夫, 久保義行「トランスポータータンパク質とアダプタータンパク質を共発現させたトランスジェニック卵母細胞」

Books (16)：

血液網膜関門における網膜への薬物輸送メカニズム
技術情報協会 2017
タウリンの体内動態とその動態にタウリントランスポーターが果たす役割
タウリン研究会 2015
血液網膜関門におけるカチオン輸送機構の研究:トランスポーターの道を巡って
日本薬剤学会 2015
CHAPTER 28. The Blood-Retinal Barrier and Carnosine
The Royal Society of Chemistry/ ELSEVIER, NED 2015 ISBN:0
Experimental Approaches to Study Drug Transporters
Wiley 2014

ｍore...

Lectures and oral presentations (8)：

血液組織関門における塩基性薬物吸排制御機構に関する研究
(日本薬物動態学会第31回年会 2016)
血液網膜関門におけるカチオン性薬物・栄養物輸送機構
(第38回生体膜と薬物相互作用シンポジウム 2016)
Impact of carrier-mediated transport of cationic neuroprotectants to the retina
(The First International Symposium on Toyama-Asia-Africa Pharmaceutical Network 2016)
第2回分子生物薬剤学セミナー「血液組織関門におけるカチオン性薬物輸送機構の解明」
(第2回分子生物薬剤学セミナー2014(富山大学) 2014)
血液組織関門におけるカチオン性薬物輸送機構の解明
(日本薬学会北陸支部第126例会 2014)

ｍore...

Education (3)：

- 2003 Osaka University Graduate School of Pharmaceutical Sciences Molecular Pharmaceutical Sciences
- 2000 Osaka University Graduate School of Pharmaceutical Sciences Molecular Pharmaceutical Sciences
- 1998 Nagoya City University Faculty of Pharmaceutical Scicences

Professional career (1)：

Ph.D. (Osaka University)

Work history (11)：

2022/04 - 現在 Teikyo University Faculty of Pharma-Science Professor
2021/04 - 2022/03 Teikyo University Faculty of Pharma-Science Associate Professor
2013/07 - 2021/03 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Associate Professor
2011/04 - 2013/06 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Senior Assistant Professor
2010/04 - 2011/03 Tohoku Univeristy Assistant Professor

Show all

Committee career (15)：

2018 - 日本薬剤学会第34回年会組織委員
2017 - トランスポーター研究会世話人
2017 - 第12回トランスポーター研究会年会長
2017 - Drug Metabolism and Pharmacokinetics Editorial Avisory Board Member
2017 - Journal of Pharmaceutical Sciences Editorial Avisory Board Member

Show all

Awards (8)：

2018/09 - University of Toyama Special Award in Toyama Academic GALA 2018
2018 - 2018 Top Reviewer in Journal of Pharmaceutical Sciences
2017 - 2017 Top Reviewer in Journal of Pharmaceutical Sciences
2016/10 - JSSX Award for Young Scientists
2014/11 - Academic Incentive Award from the Hokuriku Branch of the Pharmaceutical Society of Japan

Show all

Association Membership(s) (17)：

トランスポーター研究会 , American Society for Biochemistry and Molecular Biology (ASBMB) , American Association of the Pharmaceutical Scientists (AAPS) , International Society for the Study of Xenobiotics (ISSX) , 日本分子生物学会 , 日本生化学会 , 日本薬剤学会 , 日本薬物動態学会 , 日本薬学会 , American Society for Biochemistry and Molecular Biology (ASBMB) , American Association of the Pharmaceutical Scientists (AAPS) , International Society for the Study of Xenobiotics (ISSX) , Academy of Pharmaceutical Science and Technology, Japan , Molecular Biology Society of Japan , Pharmaceutical Society of Japan , Japanese Society for the Study of Xenobiotics , Japanese Biochemical Society

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page